KV channels contribute to thermal hyperaemia in skeletal muscle of humans
Abstract figure legend Using skeletal muscle microdialysis and pulsed short‐wave diathermy, we examined the contribution of KV channels to thermal hyperaemia in human skeletal muscle. KV channel antagonism with 4‐aminopyridine attenuated thermal hyperaemia by ∼65%, identifying a critical downstream role for these ion channels in the vasodilatory ...
Ysabella I. Ruiz‐Pick +5 more
wiley +1 more source
Injectable thermosensitive hydrogel incorporating exosome-loaded chitosan microspheres for immunomodulation and cartilage regeneration. [PDF]
Xiong L +5 more
europepmc +1 more source
Synergistic Regulation of Biomaterials and Macrophages: A Novel Paradigm in Immunotherapy
Bioengineered materials mediating the modulation of macrophage plasticity and inflammatory signals in the tumor microenvironment effectively remodel immunoregulatory states, boost antitumor immunity, and promote tissue repair, achieving synergistic therapeutic outcomes.
Jiayu Zhang +16 more
wiley +1 more source
Dual-Stimuli Injectable Platforms for Localized Breast Cancer Therapy. [PDF]
Nieto C +3 more
europepmc +1 more source
Therapeutic peptide self‐assembly is governed by multiple non‐covalent interactions, enabling the construction of diverse supramolecular structures. These self‐assembled systems can be engineered through spontaneous self‐assembly of monomers, co‐assembly, or stimulus‐responsive strategies to improve tumor delivery efficiency.
Yuelin Fang +6 more
wiley +1 more source
An injectable thermosensitive PLGA-PEG-PLGA hydrogel integrated with coordination-driven self-assembled MTX-Mn nanoparticles for enhanced melanoma therapy <i>via</i> mitochondrial dysfunction. [PDF]
Xu X, Zhou Y, Chen J, Fei L, Qi M.
europepmc +1 more source
In this study, 100 cadaveric temporal bones underwent synchrotron radiation phase‐contrast imaging. Images were segmented to produce 3D surface mesh models for morphological analysis. Measurements obtained for all cochleae included: standard gross dimensions, various cochlear lengths including basilar membrane length, detailed intracochlear scalar ...
Sumit K. Agrawal +4 more
wiley +1 more source
pH-/Temperature-Triggered Gel Transition of Hyperbranched PEI-g-PDMAEMA as a Dual-Responsive Inhibitor for Clay Hydration Control. [PDF]
Zhong M, Xiong Y.
europepmc +1 more source
Kinetics of Thermosensitivity in WiDr Cells and Effects of Anticancer Drugs on the Thermosensitivity
openaire +2 more sources
Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj +23 more
wiley +1 more source

