Results 71 to 80 of about 47,392 (277)

Effective Use of Euphorbia milii DCM Root Extract Encapsulated by Thermosensitive Immunoliposomes for Targeted Drug Delivery in Prostate Cancer Cells

Current Issues in Molecular Biology
The delivery of anticancer drugs using nanotechnology is a promising approach aimed at improving the therapeutic efficacy and reducing the toxicity of chemotherapeutic agents.
Keamogetswe Riet, Ayodeji Adegoke, Samson Mashele, Mamello Sekhoacha   +3 more
doaj   +1 more source

Water model determines thermosensitive and physicochemical properties of poly(N-isopropylacrylamide) in molecular simulations

Frontiers in Materials, 2023
Poly (N-isopropylacrylamide) (PNIPAM) is a famous representative of thermosensitive polymers. Thermosensitive polymers undergo a phase transition with lower critical solution temperature.
Patrick K. Quoika, Patrick K. Quoika, Anna S. Kamenik, Anna S. Kamenik, Monica L. Fernández-Quintero, Martin Zacharias, Klaus R. Liedl   +6 more
doaj   +1 more source

Avoiding chromosome pathology when replication forks collide [PDF]

, 2013
This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2013 Macmillan Publishers Limited.Chromosome duplication normally initiates through the assembly of replication fork complexes at defined ...
Lloyd, RG, Nieduszynski, CA, Stockum, A, Upton, AL   +3 more
core   +1 more source

Precise Regulation of Membrane Proteins: From Physical Technology to Biomolecular Strategy

Advanced Science, EarlyView.
This review summarizes the emerging strategies for the precise regulation of membrane proteins using physical stimuli and biomolecule‐based tools. These methods provide new insights into cell regulation and offer promising directions for future disease treatment.
Xiu Zhao, Qingqing Zhou, Mengli Li, Wen Zou, Zhenzhong Zhang, Jinjin Shi, Junjie Liu   +6 more
wiley   +1 more source

A thermosensitive mutation alters the effects of lacosamide on slow inactivation in neuronal voltage-gated sodium channels, NaV 1.2.Mena Abdelsayed1, Stanislav Sokolov1, Peter C. Ruben*1 - These authors contributed equally to this work* - Corresponding author

Frontiers in Pharmacology, 2013
Epilepsy is a disorder characterized by seizures and convulsions. The basis of epilepsy is an increase in neuronal excitability that, in some cases, may be caused by functional defects in neuronal voltage gated sodium channels (NaVs).
Mena eAbdelsayed, Stanislav eSokolov, Peter eRuben   +2 more
doaj   +1 more source

Pluronic F-127 hydrogel as a promising scaffold for encapsulation of dental-derived mesenchymal stem cells. [PDF]

, 2015
Dental-derived mesenchymal stem cells (MSCs) provide an advantageous therapeutic option for tissue engineering due to their high accessibility and bioavailability.
Ansari, Sahar, Chen, Chider, Diniz, Ivana MA, Marques, Márcia M, Moshaverinia, Alireza, Shi, Songtao, Xu, Xingtian, Zadeh, Homayoun H   +7 more
core   +1 more source

Targeting NRP1 in Endothelial Cells Facilitates the Normalization of Scar Vessels and Prevents Fibrotic Scarring

Advanced Science, EarlyView.
Scars exhibit vascular abnormal alterations, including upregulated NRP1 expression in endothelial cells, increased vascular density and branching, compromised vessel wall integrity, and incomplete pericyte coverage. Therapeutic targeting of NRP1 through hydrogel spray delivery offers a promising approach to normalize aberrant vasculature and prevent ...
Yu Wang, Xin Zhou, Min Liu, Meimei Huang, Peirong Chen, Xinying Li, Fangchao Xue, Wenyan Zhao, Di Liu, Lang Li, Yuangang Lu, Wen Zeng   +11 more
wiley   +1 more source

NIR‐Activatable Domino Cascade Catalysis Nanozyme Reactor for Multi‐Mechanism Synergistic Immunotherapy in Bladder Cancer

Advanced Science, EarlyView.
This study presents an intravesical delivery strategy of ferroptosis‐ and immunity‐inducing nanozyme‐loaded thermoresponsive hydrogels (FMCC@PNH) for enhanced bladder cancer therapy. Abstract Current intravesical therapies for bladder cancer after resection are limited by poor tissue penetration, off‐target effects, and insufficient efficacy.
Yongnan Jiang, Qingling Zhang, Yuhan Zhang, Xinlu Yu, Bo Jia, Yulong Dong, Yalong Wu, Kelong Fan, Xinquan Gu, Lei Ji, Wei Jiang, Bin Liu   +11 more
wiley   +1 more source

A Bioinstructive Injectable Hydrogel for Enhancing Intrinsic Regeneration through Cell Recruitment and Training

Advanced Science, EarlyView.
A bioinstructive injectable hydrogel enables sustained release of stromal cell–derived factor‐1 alpha (SDF‐1α) and stable retention of laminin through ionic and hydrophobic interactions. This dual‐signaling matrix promotes endogenous stem cell recruitment and training, supports angiogenesis, and enhances intrinsic regenerative processes in ischemic ...
Yurim Kim, Young‐Min Kim
wiley   +1 more source

Síntesis de hidrogeles termosensibles de poli(N‑isopropilacrilamida)-co-poli(N,N,-dimetilacrilamida) Synthesis of thermosensitive hydrogels of poly(N-isopropylacrylamide)-co-poly(n,n-dimethylacrylamide)

Polímeros, 2013
En este trabajo se realizo la copolimerización de la N-isopropilacrilamida (NIPA) com la N,N, dimetilacrilamida (DIMA), obteniéndo se un incremento em la temperatura de transición de las muestras, cuando se aumentaba la proporción de DIMA adicionada, se ...
Jorge Alberto Cortés Ortega
doaj