Results 31 to 40 of about 42,577 (150)
Angewandte Chemie, Volume 137, Issue 19, May 5, 2025.The discovery of LIBX‐A401, a potent and selective ACSL4 inhibitor derived from rosiglitazone is reported. HDX‐MS reveals that LIBX‐A401 stabilizes the ACSL4 C‐terminus and alters the fatty acid (FA) gate domain. Consistently, photoaffinity labeling, molecular dynamics, and mutagenesis identify key binding residues within the FA pocket.
Darius Mazhari Dorooee +19 more
wiley +2 more sources
Targeting the Tumor Microbiota in Cancer Therapy Basing on Nanomaterials
Exploration, EarlyView.Intra‐tumoral microbiota, which is a potential component of the tumor microenvironment, has been emerging as a key participant and driving factor in cancer. This article reviews the latest progress in this field, including the microbial community within tumors and its pro‐cancer mechanisms, as well as the anti‐tumor strategies targeting intra‐tumoral ...
Yanan Niu +4 more
wiley +1 more source
New results related to QGP-like effects in small systems with ALICE
, 2016 Results on the production of $\pi^{\pm}$, $\textrm{K}^{\pm}$, $\textrm{p}(\bar{\textrm{p}})$, $\Lambda(\bar{\Lambda})$, $\Xi^{-} \left(\bar{\Xi}^{+}\right)$ and $\Omega^{-} \left(\bar{\Omega}^{+}\right)$ at midrapidity (${|y|
Vislavicius, Vytautas
core +1 more source
Black Garlic: Production Process, Bioactive Compounds, and Health Effects
Food Chemistry International, EarlyView.Black garlic, produced under controlled temperature and humidity, undergoes biochemical transformations that enhance its antioxidant capacity, bioactive compounds, and unique flavor profile. This review highlights its production process, health benefits, and functional food potential based on scientific evidence.
Hatice Kubra Sasmaz +3 more
wiley +1 more source
Thermal description of hadron production in e+e- collisions revisited
, 2009 We present a comprehensive analysis of hadron production in e+e- collisions at different center-of-mass energies in the framework of the statistical model of the hadron resonance gas.
A. Andronic +40 more
core +1 more source
Plasmid-based lacZalpha assay for DNA polymerase fidelity: application to archaeal family-B DNA polymerase [PDF]
, 2009 The preparation of a gapped pUC18 derivative, containing the lacZalpha reporter gene in the single-stranded region, is described. Gapping is achieved by flanking the lacZalpha gene with sites for two related nicking endonucleases, enabling the excision ...
Bebenek +28 more
core +2 more sources
, 2016 New results of the NA61/SHINE Collaboration at the CERN SPS on mean hadron multiplicities in proton-proton (p+p) interactions are analyzed within the transport models and the hadron resonance gas (HRG) statistical model.
Begun, V. V. +2 more
core +1 more source
Molecular Ecology Resources, EarlyView.ABSTRACT The vertebrate gut houses diverse microbial communities that provide insights into their host's ecological and evolutionary histories. Nevertheless, microbiome research has not been distributed equally across host taxonomy, geography and timescales. The millions of fluid‐preserved specimens stored in natural history museums worldwide represent
Samantha S. Fontaine +4 more
wiley +1 more source
Structural insights into RNA processing by the human RISC-loading complex. [PDF]
, 2009 Targeted gene silencing by RNA interference (RNAi) requires loading of a short guide RNA (small interfering RNA (siRNA) or microRNA (miRNA)) onto an Argonaute protein to form the functional center of an RNA-induced silencing complex (RISC).
AD Haase +41 more
core +2 more sources
Entomologia Experimentalis et Applicata, EarlyView.The caterpillars of the greater wax moth (Galleria mellonella) (Lepidoptera: Pyralidae) are emerging models to study innate immunity and plastic biodegradation. Both of these processes are impacted by the associations between the insect host and its gut microbiome. Although bacterial flora harbored by the larvae have been characterized, little is known
Ben G. Pilling +2 more
wiley +1 more source