Results 21 to 30 of about 6,465 (254)

Total Chemical Synthesis of Interleukin‐15 and Interleukin‐2: Taming Protein Hydrophobicity and Aggregation by a Versatile Solubilizing Strategy

Angewandte Chemie, EarlyView.
A reducible solubilizing tag strategy (RST‐2.0) enables the synthesis, purification and ligation of difficult peptides while being readily removable just during folding, which overcomes the common challenges from protein hydrophobicity and aggregation. With this method, we achieved the first total synthesis of native and N‐glycosylated IL‐15 as well as
Jingwen Zeng, Haiyan Zhou, Wang Xia, Hongxiang Wu, Xuechen Li   +4 more
wiley   +2 more sources

76 | DECODING THES PATHOGENESIS: HOW TTC37 SHAPES GUT HOMEOSTASIS AND PERISTALSIS

European Journal of Histochemistry
Trichohepatoenteric Syndrome (THES) is an ultra-rare, multisystem disorder caused by biallelic mutations in the TTC37 or SKIV2L genes, which encode essential subunits of the SKI complex, a cofactor for the RNA exosome. The hallmark of THES is intractable
GEI - SOCIETÀ ITALIANA DI BIOLOGIA DELLO SVILUPPO E DELLA CELLULA
doaj   +1 more source

Academic rankings: an approach to rank portuguese universities Rankings académicos: un abordaje para clasificar las universidades portuguesas Rankings acadêmicos: uma abordagem ao ranking das universidades portuguesas

Ensaio, 2010
The academic rankings are a controversial subject in higher education. However, despite all the criticism, academic rankings are here to stay and more and more different stakeholders use rankings to obtain information about the institutions' performance.
Pedro Bernardino, Rui Cunha Marques
doaj   +1 more source

Inconsistent year-to-year fluctuations limit the conclusiveness of global higher education rankings for university management [PDF]

PeerJ, 2015
Backround. University rankings are getting very high international media attention, this holds particularly true for the Times Higher Education Ranking (THE) and the Shanghai Jiao Tong University’s Academic Ranking of World Universities Ranking (ARWU ...
Johannes Sorz, Bernard Wallner, Horst Seidler, Martin Fieder   +3 more
doaj   +2 more sources

The species of the genus Hypodynerus de Saussure (Hymenoptera, Vespidae, Eumeninae) occurring in Brazil

ZooKeys, 2013
An identification table and descriptions are given to recognize the two species of Hypodynerus (Hymenoptera: Vespidae: Eumeninae) recorded from Brazil: H. arechavaletae (Brèthes) and H. duckei (Bertoni) comb. n. The lectotype is designated and the
Bolívar Garcete-Barrett, Marcel Hermes
doaj   +1 more source

Surfactant-Enhanced Extraction of Lutein from Marigold Petals using an Aqueous Two-Phase System

Separations, 2023
The extraction of lutein from marigold petals using a surfactant-based aqueous two-phase system is reported. In this work, the effectiveness of the hydrophilic-lipophilic balance of surfactants on extraction performance for the extraction of lutein from ...
Neha Maheshwari, Raj Kumar Arya, George D. Verros, Pradip B. Dhamole, Ashwin Kannan   +4 more
doaj   +1 more source

Thermoelectric PANI/TeNWs Fiber Based Microsensor for Passive Temperature and Active Chemical Sensing

Advanced Science, EarlyView.
Continuous wet‐spinning of PANI with TeNWs yields a multifunctional microfiber. Oriented TeNWs impose chain alignment and enhance π‐electron delocalization, boosting the Seebeck coefficient to 59.9 µV K−1 for passive temperature sensing (1 K detection limit), while achieving high pH sensitivity (59.25 mV pH−1) and rapid NH3 response (0.96 s).
Dongmei Xie, Mengran Chen, Xuefei Zhang, Yan Xu, Weiye Geng, Zhe Tang, Si‐ze Lou, Shun Wan, Zhenguo Liu, Heng Liu, Peng‐an Zong   +10 more
wiley   +1 more source

PREPARING UNIVERSITAS TERBUKA FOR A WORLD-CLASS UNIVERSITY THROUGH INTERNATIONAL RANKING SYSTEM [PDF]

AAOU Journal, 2009
Universitas Terbuka (UT) aims at achieving a world class standard. As one of the criteria of a world class university is the world ranking, it is planned that the university should achieve a high position within the ranking.
Diki, Susy Puspitasari, Jasrial, Agus Djaya   +3 more
doaj   +1 more source

Correction of Ineffective Erythropoiesis and Normalization of Iron Homeostasis After Exagamglogene Autotemcel in Transfusion‐Dependent β‐Thalassemia

American Journal of Hematology, EarlyView.
ABSTRACT Exagamglogene autotemcel (exa‐cel) is a one‐time, ex vivo, CRISPR‐Cas9 gene edited cell therapy approved for patients with transfusion dependent β‐thalassemia (TDT) aged 12–35 years. In a Phase 3 study (CLIMB THAL‐111), exa‐cel treatment resulted in reactivation of fetal hemoglobin and increases in total hemoglobin, leading to transfusion ...
Sujit Sheth, Selim Corbacioglu, Josu de la Fuente, Mattia Algeri, Joachim Rupprecht, Kevin H. M. Kuo, Ami J. Shah, Peter Lang, Hayley Merkeley, Ben Carpenter, Markus Y. Mapara, Robert I. Liem, Stephan Grupp, Yogi Chopra, Amanda M. Li, Janet L. Kwiatkowski, Melanie Kirby‐Allen, Maria Domenica Cappellini, Antonis Kattamis, Sakellarios Zairis, Tina Liu, William Hobbs, Haydar Frangoul, Franco Locatelli, Roland Meisel, on behalf of the CLIMB THAL‐111 and CLIMB‐131 Study Groups   +25 more
wiley   +1 more source

Citrus aurantium honey‐mediated gut homeostasis and anti‐inflammation via Thorl/Nprl2‐TORC1 signaling: Network pharmacology and Drosophila validation

Animal Models and Experimental Medicine, EarlyView.
The study employed a four‐tiered strategy: (1) UHPLC‐FTMS profiling of Citrus aurantium honey to characterize its chemical composition; (2) network pharmacology analysis integrating target prediction, protein–protein interaction networks, and KEGG pathway enrichment to identify the Thor1/Nprl2‐TORC1 axis as a key mechanistic pathway; (3) in vitro ...
Wenqi Wan, Ruiguang Huang, Shuqiong Cao, Luxia Pan, Wenkai Zhang, Wujun Jiang, Zhiyong Liu   +6 more
wiley   +1 more source