Results 31 to 40 of about 6,465 (254)

Biochemical and Immunohistochemical Associations of TDP‐43 and Cryptic RNA With Hippocampal and Amygdala Volumetrics in Alzheimer's Disease

Annals of Neurology, EarlyView.
Objective Immunohistochemically (IHC) measured transactive response DNA‐binding protein 43 (TDP‐43) inclusions are observed in Alzheimer's disease (AD) and are associated with medial temporal lobe atrophy. Accumulation of cryptic exons occurs in AD in response to TDP‐43 pathology.
Hossam Youssef, Rodolfo G. Gatto, Nikhil B. Ghayal, Virginia Estades Ayuso, Karen R. Jansen‐West, Judith A. Dunmore, Yuping Song, Mei Yue, Casey N. Cook, Michael DeTure, Bailey D. Rawlinson, Monica Castanedes‐Casey, Clifford R. Jack Jr, Ronald C. Petersen, Dennis W. Dickson, Leonard Petrucelli, Jennifer L. Whitwell, Mercedes Prudencio, Keith A. Josephs   +18 more
wiley   +1 more source

Alzheimer's Disease Co‐Pathology and Cognitive Impairment in Amyotrophic Lateral Sclerosis

Annals of Neurology, EarlyView.
Objectives Amyotrophic lateral sclerosis (ALS) and Alzheimer's disease (AD) share neuropathological features, including tau, amyloid, and TDP‐43 pathology. This study investigated whether AD‐related pathological changes are associated with cognitive impairment ALS. Methods Cerebrospinal fluid (CSF total‐tau, phosphorylated‐tau, beta‐amyloid) and plasma
Elisabeth Kasper, Annaliis Lehto, Alexandra Jürs, Nina Nordmann, Oliver Peters, Julian Hellmann, Josef Priller, Eike Jakob Spruth, Gabor C. Petzold, Ina Voigt, Patrick Weydt, Sarah Bernsen, Elisabeth Dinter, Björn Falkenburger, René Günther, Emrah Düzel, Wenzel Glanz, Matthis Synofzik, Lukas Beichert, Annika Spottke, Michael Wagner, Frederic Brosseron, Matthias C. Schmid, Annett Halle, Jochen Herms, Anja Schneider, Stefan Teipel, Johannes Prudlo, Manuela Neumann, Andreas Hermann   +29 more
wiley   +1 more source

Gephyrin Neurological Autoimmunity

Annals of Neurology, EarlyView.
Gephyrin is a postsynaptic scaffold protein essential for inhibitory neurotransmission. Gephyrin‐immunoglobulin G (IgG) was reported, decades ago, in a single case of paraneoplastic stiff‐person‐like syndrome, but its broader clinical relevance remains unknown.
Maria Chiara Pantuliano, Friederike A. Arlt, Naomi Arenson, Irena Dujmovic Basuroski, Divyanshu Dubey, Connie E. Lesnick, John R. Mills, Sean J. Pittock, Anastasia Zekeridou, Michael A. Lane, Andrew McKeon   +10 more
wiley   +1 more source

Elimination of fukutin reveals cellular and molecular pathomechanisms in muscular dystrophy-associated heart failure

Nature Communications, 2019
Mutations in Ftkn cause Fukuyama muscular dystrophy, and heart failure is the main cause of death in thes patients. Here the authors show that acute elimination of Fktn in adult mice causes early mortality, and this is associated with myocyte dysfunction,
Yoshihiro Ujihara, Motoi Kanagawa, Satoshi Mohri, Satomi Takatsu, Kazuhiro Kobayashi, Tatsushi Toda, Keiji Naruse, Yuki Katanosaka   +7 more
doaj   +1 more source

Cases of Trichohepatoenteric Syndrome (Syndromic Diarrhea) with Underlying Crohn’s Disease

Вопросы современной педиатрии, 2015
Tricho-hepato-enteric syndrome (syndromic, phenotypic diarrhea, SD/THES) is a rare inborn disease, which affects bowels. It is caused by the mutation of genes SKIV2L or TTC37. Manifestations include intrauterine hypotrophy, severe chronic diarrhea, which
Е. А. Roslavtseva, Т. E. Borovik, Е. G. Tsimbalova, А. О. Anushenko, А. S. Potapov, М. М. Lokhmatov, I. L. Chashchina, М. D. Bakradze   +7 more
doaj   +1 more source

New records of aphid parasitoids (Hymenoptera) from Colombia [PDF]

Check List, 2019
Aphid parasitoids have been recorded in many countries around the globe, however records in Colombia are few. Here, five primary parasitoids species, Aphidius platensis Brèthes, 1913, Aphidius funebris Mackauer, 1961, Aphidius matricariae ...
Laura Marcela Martínez-Chávez, Diana Nataly Duque-Gamboa, Nelson Toro-Perea   +2 more
doaj   +3 more sources

Is theS-meson a baryonium state?

Zeitschrift f�r Physik C Particles and Fields, 1979
If theS-meson is assumed to be a baryonium state composed of an isospin one diquark and antidiquark, it will be produced in\(\bar pp\) reactions as a mixture ofI=0 andI=1 baryonium states. The experimentally observed large ratio of the cross sections of the reactions\(\bar pp \to S \to \bar pp\) and\(\bar pp \to S^0 \to \bar nn\) is then explained on ...
openaire   +1 more source

On the nature of theS * and related scalar resonances

Zeitschrift f�r Physik C Particles and Fields, 1981
Recent data on ππ andK−K production are analysed in order to explore resonant effects in isospin zeroS wave scattering near theK−K threshold. Various coupled-channel formalisms are considered and information from above and below threshold is used. We identify, and determine the properties of,S* and ɛ (1400) resonance structures.
A. C. Irving, A. D. Martin, P. J. Done
openaire   +1 more source

Prediction of total hospital expenses of patients undergoing breast cancer surgery in Shanghai, China by comparing three models

BMC Health Services Research, 2021
Background Breast cancer imposes a considerable burden on both the health care system and society, and becomes increasingly severe among women in China.
Minjie Chen, Xiaopin Wu, Jidong Zhang, Enhong Dong   +3 more
doaj   +1 more source

Surface Charges Guided Quasi‐TEM‐mode Microwave Propagation along Dielectric Nanowire

Advanced Physics Research, EarlyView.
According to Maxwell's equations, a single‐conductor transmission line cannot allow TEM‐mode electromagnetic wave propagation, however, this is based upon the assumption that dielectric material is isolated from the environment. In practice, surface electrostatic charges widely existed in nano‐materials with large surface‐to‐volume ratio.
BoYan Xu, Kaibo Zhang, Haojie Gao, Zhiyuan Gao, Kai Wang, Lihuan Zhao, Qi Yang, Bifeng Cui   +7 more
wiley   +1 more source