Results 111 to 120 of about 876,345 (259)

Cannabis-based treatment induces polarity-reversing plasticity assessed by theta burst stimulation in humans

, 2009
In animal models, the cannabinoid system has been convincingly implicated in the regulation of long-lasting synaptic plasticity. Both long-term potentiation (LTP) and depression (LTD) phenomena can be induced in the human motor cortex by transcranial ...
Kusayanagi, H, Buttari, F, Monteleone, F, BERNARDI, GIORGIO, Mori, F, CENTONZE, DIEGO, Koch, G, Fiore, S, Francesco Mori, MD, Centonze D, Diego Centonze, MD, Giacomo Koch, MD, PhD, Koch G, Fabio Buttari, MD, Giorgio Bernardi, MD, Fiore S, Bernardi G, Claudia Codecà, MD, Codecà C, Hajime Kusayanagi, MD, Stefania Fiore, MD, Mori F, Codecà, C, Buttari F, Kusayanagi H, Monteleone F, Fabrizia Monteleone, MD   +26 more
core   +1 more source

Hemisphere-specific effects of prefrontal theta-burst stimulation on visual recognition memory accuracy and awareness [PDF]

, 2019
Article describes study seeking to determine if theta-burst transcranial magnetic stimulation (TBS) to prefrontal cortex modulates visual memory accuracy, visual memory awareness, or both, and whether these effects depend on brain ...
Carbajal, Ivan, Palumbo, Robert T., Ivan Carbajal, Jonathan T. O’Neil, Joel L. Voss, Ryals, Anthony J., Robert T. Palumbo, Anthony J. Ryals, Voss, Joel L., O'Neil, Jonathan T.   +9 more
core   +1 more source

Disease Progression Mathematical Modeling With a Case Study on Hepatitis B Virus Infection

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 420-434, March 2025.
ABSTRACT Chronic Hepatitis B presents a significant health and socioeconomic burden. The risk of hepatocellular carcinoma remains elevated although treatments are available. Achieving an optimal treatment regimen necessitates a deep comprehension of the dynamic relationship between the virus and its host across disease states.
Clémence Boivin‐Champeaux, Nieves Velez de Mendizabal, Aksana Jones, Scott Balsitis, Stephan Schmidt, Justin S. Feigelman, Francine Johansson Azeredo   +6 more
wiley   +1 more source

Establishment of a Human Cell‐Based In Vitro Test System for Investigating and Evaluating Cytotoxic and Immunomodulatory Effects of Indoor Mold

Environmental Toxicology, EarlyView.
ABSTRACT Mold growth in damp indoor environments is a widespread problem associated with respiratory health effects, though causal mechanisms remain incompletely understood. We established a human cell‐based in vitro test system using bronchial epithelial cells (NuLi‐1) and macrophages (THP‐1) to assess inhalation toxicity and immunomodulatory effects ...
Anja Wolff, Jessica Reinert, Silke Steinborn, Marion Berger, Judith Neuhoff, Lennart Marske, Kerttu Valtanen, Udo Jäckel, Stefanie Klar   +8 more
wiley   +1 more source

MRI‐targeted focal transcranial magnetic stimulation reproducing habitual seizure semiology during presurgical evaluation: An instructive clinical vignette

Epileptic Disorders, EarlyView.
Guido Widman, Stiliyan Kalitzin
wiley   +1 more source

Distinctly altered TRPC3 and TRPC6 expression patterns in human Alzheimer's disease cortex and hippocampus

Brain Pathology, EarlyView.
Divergent remodeling of TRPC channels occurs in Alzheimer's disease, with TRPC3 increased in neurons and reactive astrocytes and TRPC6 reduced in pyramidal neurons. These alterations may contribute to calcium dysregulation, neuroinflammation, and synaptic dysfunction during AD progression.
Xingyong Chen, Zhengjun Wang, Jiaxing Wang, Dehui Kong, Xusheng Wang, Lu Lu, Peter T. Nelson, Fu‐Ming Zhou, Francesca‐Fang Liao   +8 more
wiley   +1 more source

Effect of time intervals of priming continuous theta burst stimulationon on cortical plasticity induced by intermittent theta burst stimulation

Zhongguo kangfu lilun yu shijian
Objective To investigate the effect of continuous theta burst stimulation-intermittent theta burst stimulation (cTBS-iTBS) priming protocols with different time intervals on the plasticity of primary motor cortex (M1). Methods A total of 39 healthy young
GENG Ayan, WANG Qinglei, SHEN Junfan, ZHU Shizhe, JI Panpan, WANG Tong, GUO Chuan   +6 more
doaj   +1 more source

Response to Ng et al. on “Stimulus‐induced arousal with transient electroencephalographic improvement distinguishes nonictal from ictal generalized periodic discharges”

Epilepsia, EarlyView.
Philippe Gélisse, William O. Tatum, Arielle Crespel, Peter W. Kaplan   +3 more
wiley   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

A Voltage-Based STDP Rule Combined with Fast BCM-Like Metaplasticity Accounts for LTP and Concurrent "Heterosynaptic" LTD in the Dentate Gyrus In Vivo.

PLoS Computational Biology, 2015
Long-term potentiation (LTP) and long-term depression (LTD) are widely accepted to be synaptic mechanisms involved in learning and memory. It remains uncertain, however, which particular activity rules are utilized by hippocampal neurons to induce LTP ...
Peter Jedlicka, Lubica Benuskova, Wickliffe C Abraham   +2 more
doaj   +1 more source