Results 71 to 80 of about 173,999 (290)

Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway [PDF]

, 2015
DNA polymerase theta (Polθ) has been identified as a crucial alternative non-homologous end-joining factor in mammalian cells. Polθ is upregulated in a range of cancer cell types defective in homologous recombination, and knockdown has been shown to ...
Aitkenhead, H, Gileadi, Opher, Cooper, Christopher D O, Newman, JA, Cooper, CD, Gileadi, O, Cooper, Christopher D.O., Newman, Joseph A., Aitkenhead, Hazel   +8 more
core   +1 more source

T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ± 
Sarah J. Wright, Scotty G. McKay, Jean Ramos Bou, Fen Bao, Vivian B. Truong, Chenyang Li, Li Jiang, Anza B. Memon, E. Mark Haacke, Yulin Ge, Yongsheng Chen   +10 more
wiley   +1 more source

Temporal Interference Stimulation of Centromedian‐Parafascicular Complex in Disorders of Consciousness: A Pilot Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Treatment of disorders of consciousness (DoC) remains a major clinical challenge, and noninvasive, targeted modulation of deep brain structures has emerged as a promising therapeutic strategy. We aimed to evaluate the feasibility/safety and preliminary effects of thalamic temporal interference stimulation (TIS) targeting centromedian‐
Gengyao Hu, Changgeng Song, Dianwei Wu, Xiaoqian Niu, Jianmin Hao, Lijuan Liu, Xiaogang Kang, Wen Jiang   +7 more
wiley   +1 more source

The impact of a mixed reality technology-driven health enhancing physical activity program among community-dwelling older adults: a study protocol

Frontiers in Public Health
BackgroundPhysical inactivity and a sedentary lifestyle among community-dwelling older adults poses a greater risk for progressive physical and cognitive decline.
Michael Joseph S. Dino, Michael Joseph S. Dino, Michael Joseph S. Dino, Kenneth W. Dion, Kenneth W. Dion, Peter M. Abadir, Chakra Budhathoki, Chakra Budhathoki, Chien-Ming Huang, William V. Padula, Cheryl R. Dennison Himmelfarb, Cheryl R. Dennison Himmelfarb, Patricia M. Davidson, Patricia M. Davidson, Patricia M. Davidson   +14 more
doaj   +1 more source

Theta blocks

Journal of the European Mathematical Society
We define theta blocks as products of Jacobi theta functions divided by powers of the Dedekind eta function and show that they give a new powerful method to construct Jacobi forms and Siegel modular forms, with applications also in lattice theory and algebraic geometry. One of the central questions is when a theta block defines a Jacobi form.
Valery Gritsenko, Nils-Peter Skoruppa, Don Zagier   +2 more
openaire   +4 more sources

A Q‐Learning Algorithm to Solve the Two‐Player Zero‐Sum Game Problem for Nonlinear Systems

International Journal of Adaptive Control and Signal Processing, Volume 39, Issue 3, Page 566-581, March 2025.
A Q‐learning algorithm to solve the two‐player zero‐sum game problem for nonlinear systems. ABSTRACT This paper deals with the two‐player zero‐sum game problem, which is a bounded L2$$ {L}_2 $$‐gain robust control problem. Finding an analytical solution to the complex Hamilton‐Jacobi‐Issacs (HJI) equation is a challenging task.
Afreen Islam, Anthony Siming Chen, Guido Herrmann   +2 more
wiley   +1 more source

Observer‐Based Adaptive Event‐Triggered Tracking Control for Fuzzy TS Systems With Premise Mismatch

International Journal of Adaptive Control and Signal Processing, EarlyView.
This paper presents an adaptive logistic event‐triggered observer‐based tracking controller for Takagi‐Sugeno fuzzy systems under constrained inputs and network delays. Leveraging a hybrid LMI and Secretary Bird Optimization approach, this strategy significantly minimizes communication overhead and computational burden while ensuring optimal reference ...
Oussama Djadane, Salama Makni, Mourad Kchaou, Ahmed El Hajjaji   +3 more
wiley   +1 more source

Brain oscillatory correlates of altered executive functioning in positive and negative symptomatic schizophrenia patients and healthy controls

Frontiers in Psychology, 2016
Working Memory and executive functioning deficits are core characteristics of patients suffering from schizophrenia. Electrophysiological research indicates that altered patterns of neural oscillatory mechanisms underpinning executive functioning are ...
Barbara eBerger, Tamas eMinarik, Birgit eGriesmayr, Renate eStelzig-Schoeler, Wolfgang eAichhorn, Paul eSauseng   +5 more
doaj   +1 more source

The Effect of Object Type on Building Scene Imagery—an MEG Study

Frontiers in Human Neuroscience, 2020
Previous studies have reported that some objects evoke a sense of local three-dimensional space (space-defining; SD), while others do not (space-ambiguous; SA), despite being imagined or viewed in isolation devoid of a background context.
Anna M. Monk, Gareth R. Barnes, Eleanor A. Maguire   +2 more
doaj   +1 more source

dynoGP: Deep Gaussian Processes for Dynamic System Identification

International Journal of Adaptive Control and Signal Processing, EarlyView.
This work introduces a novel class of deep models for system identification, dynamical deep Gaussian processes, which combine the strengths of data‐driven methods, such as those based on neural network architectures, with the ability to output a probability distribution for uncertainty representation.
Alessio Benavoli, Marco Forgione, Dario Piga, Marco Zaffalon   +3 more
wiley   +1 more source