Results 51 to 60 of about 147,836 (303)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
REID (Research and Evaluation in Education), 2018 This study is set out to (1) explore the accuracy of school-based English test items developed by English teachers and (2) compare the relationship between the content covered by teacher and the students’ success level.
Martin Iryayo, Agus Widyantoro
doaj +1 more source
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
Theta-modulated place-by-direction cells in the hippocampal formation in the rat [PDF]
, 2004 We report the spatial and temporal properties of a class of cells termed theta-modulated place-by-direction (TPD) cells recorded from the presubicular and parasubicular cortices of the rat. The firing characteristics of TPD cells in open-field enclosures
Wills, TJ +4 more
core
Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway [PDF]
, 2015 DNA polymerase theta (Polθ) has been identified as a crucial alternative non-homologous end-joining factor in mammalian cells. Polθ is upregulated in a range of cancer cell types defective in homologous recombination, and knockdown has been shown to ...
Aitkenhead, H +8 more
core +2 more sources
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
Abstract Augmented Lazy Theta*: Applying Graph Abstractions to Trajectory Planning with Speed-Limit Constraints [PDF]
, 2014 Trajectory planning is a generalisation of path planning in which velocity is also taken into consideration. Considering velocity, in the context of a real-world system such as a robotic vehicle, means considering physical constraints such as the ...
Chrpa, Lukáš, Gregory, Peter
core
Canadian Journal of Gastroenterology and HepatologyBackground. Data on the economic burden of chronic hepatitis C (CHC) among immigrants are limited. Our objective was to estimate the CHC-attributable mortality and healthcare costs among immigrants in Ontario, Canada. Methods.
Aysegul Erman +8 more
doaj +1 more source
Frontiers in Neuroscience, 2021 This study aimed to examine whether the cortical processing of emotional faces is modulated by the computerization of face stimuli (”avatars”) in a group of 25 healthy participants.
Teresa Sollfrank +14 more
doaj +1 more source