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Ocular Penetration of Thiabendazole
Archives of Ophthalmology, 1990OcularToxocara canisinfection may cause decreased vision owing to direct retinal injury by theToxocaraorganism or by secondary effects related to inflammation and scarring. Several treatment modalities for ocular toxocariasis have been advocated, including systemic antiparasitic medications, photocoagulation, and vitreous surgery.
A M, Maguire +3 more
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Tolerance of Chickens to Thiabendazole
Nature, 1966THIABENDAZOLE, a broad-spectrum anthelmintic1,2, is well tolerated by mice, rats and rabbits, with LD50 values exceeding 3.1 g/kg in oral acute toxicity experiments3. Furthermore, rats and dogs tolerated the drug quite well in chronic toxicity experiments3.
D, Polin, K, Kelley, E, Lehman, W H, Ott
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Thiabendazole in hookworm infection
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1966Abstract Thiabendazole was administered orally to 100 patients infected with hookworms. 60% harboured A. duodenale and 40% N. americanus. The mean ova count per gramme of faeces was 7178 ± 5166. 5 dosage schedules were tried, and therapeutic efficiency was assessed by finding out the percentage reduction in egg count. With 100 mg. per kg.
D V, Sabharwal +4 more
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Anticonvulsant action of thiabendazole
European Journal of Pharmacology, 1977Thiabendazole was found to be specifically effective against maximal electroshock seizures in albino rats. It produced a significant dose-dependent decrease in the duration of the tonic extensor phase of hind legs. The ED50 was similar for oral or s.c. administration.
C, Shashindran, I S, Gandhi, N S, Parmar
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Food and Chemical Toxicology, 1991
Thiabendazole [2-(4'-thiazolyl)benzimidazole; TBZ], a teratogen in ICR mice, is known to be mainly metabolized to 5-hydroxy-TBZ (5-OH-TBZ) and its conjugates in domestic and laboratory animals. Besides the known metabolites of TBZ, 4-hydroxy-TBZ and 2-acetylbenzimidazole (ABI) were identified as new metabolites of TBZ in the urine of F344 rats and ICR ...
T, Fujitani +5 more
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Thiabendazole [2-(4'-thiazolyl)benzimidazole; TBZ], a teratogen in ICR mice, is known to be mainly metabolized to 5-hydroxy-TBZ (5-OH-TBZ) and its conjugates in domestic and laboratory animals. Besides the known metabolites of TBZ, 4-hydroxy-TBZ and 2-acetylbenzimidazole (ABI) were identified as new metabolites of TBZ in the urine of F344 rats and ICR ...
T, Fujitani +5 more
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Thiabendazole in Pinworm Infestations
Archives of Pediatrics & Adolescent Medicine, 1965THIABENDAZOLE HIABENDAZOLE * (2- (4′ Thiazolyl)-benzimidazole) has been used extensively as a veterinary anthelmintic. More recently it has been employed in the treatment of various human parasitic infestations, including strongyloidiasis, ascariasis, hookworm, trichuriasis, creeping eruption, and trichinosis.
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Thiabendazole in human filariasis
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1966Abstract Thiabendazole was used in the treatment of patients with Loa loa, A. perstans and O. volvulus infections, in a dose of 25 mg. per kg. twice a day for 5–10 days, and was found ineffective. This study was prompted by its reported efficacy in the treatment of tropical eosinophilia and trichinosis.
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