Results 141 to 150 of about 34,352 (291)

Implementing early detection of cognitive impairment in primary care to improve care for older adults

open access: yesJournal of Internal Medicine, Volume 298, Issue 1, Page 31-45, July 2025.
Abstract Primary care is the ideal setting for early detection of mild cognitive impairment (MCI) and Alzheimer's disease and related dementias (ADRD), as it serves as the primary point of care for most older adults. With the growing aging population, reliance on specialists for detection and diagnosis is unsustainable, highlighting the need for ...
Nicole R. Fowler   +15 more
wiley   +1 more source

Maternal Gestational Weight Status and Offspring Physical Growth Status at Birth, Mid‐Childhood and Early Adolescence

open access: yesMaternal &Child Nutrition, Volume 21, Issue 3, July 2025.
This study examined the associations of maternal body mass index (BMI) and gestational weight gain (GWG) with offspring physical growth from birth to early adolescence in rural western China. Findings reveal that higher maternal BMI and excessive GWG significantly predict increased offspring BMI and height, with the strongest effects observed in early ...
Yingze Zhu   +8 more
wiley   +1 more source

Engineering of the Thiamine Diphosphate‐Dependent JanthE for the Synthesis of Tertiary Alcohols

open access: yesChemistry – A European Journal, Volume 31, Issue 35, June 23, 2025.
The synthesis of chiral tertiary alcohols is in high demand. Here we investigate in detail the aldehyde–ketone cross‐coupling reactions catalyzed by the promising thiamine diphosphate‐dependent lyase JanthE. Focusing on both reaction parameters and engineering, we rationally develop JanthE to improve its applicability and demonstrate its evolvability ...
Lucrezia Lanza   +7 more
wiley   +1 more source

Designing Enzymatic Reactivity with an Expanded Palette

open access: yesChemBioChem, Volume 26, Issue 11, June 3, 2025.
Innovation in biocatalysis is rapidly increasingly the diversity of catalytic reactivity that can be mediated by enzymes, addressing a key bottleneck for their widespread adoption in industrial chemical synthesis. A key approach to this is building enzymes with unnatural catalytic components that provide an expanded palette with new possibilities for ...
Reuben B. Leveson‐Gower
wiley   +1 more source

Thiamine Acquisition Strategies Impact Metabolism and Competition in the Gut Microbe Bacteroides thetaiotaomicron. [PDF]

open access: yes, 2017
Thiamine (vitamin B1) is an essential cofactor for all organisms. Humans primarily acquire thiamine through their diet, and thiamine deficiencies have adverse neurological effects.
Costliow, Zachary A, Degnan, Patrick H
core  

Thiamine deficiency in pregnancy and lactation: implications and present perspectives. [PDF]

open access: yesFront Nutr, 2023
Kareem O   +4 more
europepmc   +1 more source

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