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INDUCED THIAMIN DEFICIENCY IN LAMBS [PDF]

open access: possibleAustralian Veterinary Journal, 1981
By following a feeding regimen which consistently induced polio‐encephalomalacia in pre‐ruminant lambs it was possible to study certain characteristics just before the terminal stage in poliocencephalomalacia.There was always a marked deficit in erythrocyte precursors in bone marrow and this preceded any pathological changes in the brain.
C. R. Huxtable   +3 more
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Role of astrocytes in thiamine deficiency

Metabolic Brain Disease, 2014
Thiamine deficiency (TD) is the underlying cause of Wernicke's encephalopathy (WE), an acute neurological disorder characterized by structural damage to key periventricular structures in the brain. Increasing evidence suggests these focal histological lesions may be representative of a gliopathy in which astrocyte-related changes are a major feature of
Rémi Labetoulle   +3 more
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Thiamine Deficiency in Honeyeaters

Journal of Avian Medicine and Surgery, 2002
Twelve helmeted honeyeaters (Lichenostomus melanops cassidix), 11 yellow-tufted honeyeaters (Lichenostomus melanops gippslandica), 3 purple-crowned lorikeets (Glossopsitta porphyrocephala), and 3 little lorikeets (Glossopsitta pusilla) died over a short period of time with acute thiamine deficiency. Diagnosis was based on polioencephalomalacia observed
Peter H. Holz   +2 more
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Thiamine deficiency in the critically ill

Intensive Care Medicine, 1988
There have been recent reports of hospitalised patients developing clinical thiamine deficiency, combined with much debate on the optimal supplementation of thiamine for the parenterally fed patient, particularly in the intensive therapy environment.
A. Shenkin   +2 more
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Thiamine Deficiency and Glyoxylic Acid

Annals of Nutrition and Metabolism, 1981
The effect of thiamine deficiency on glyoxylic acid metabolism in mice and rats was investigated to determine whether the vitamin deficiency results in gross effects on glyoxylate levels via an alteration in the activity of alpha-ketoglutarate:glyoxylate carboligase.
Ronald.W. Brosemer   +2 more
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Lactic acidosis in thiamine deficiency

Clinical Nutrition, 1993
Two chronically ill patients with limited nutritional intake during several weeks developed prolonged lactic acidosis. As no other causes of hyperlactaemia could be identified, thiamine deficiency was suspected. Supplementation of 600 mg thiamine resulted in a rapid normalisation of serum lactate levels (in patient 1 from 10.9-2.4 mmol/l; in patient 2 ...
Wilfred Druml   +5 more
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Thiamine deficiency and cardiovascular disorders

Nutrition, Metabolism and Cardiovascular Diseases, 2018
Thiamine, also known as vitamin B1, functions as a cofactor in the metabolism of carbohydrates and amino acids. Thiamine deficiency has been suggested to be associated with many cardiovascular diseases (CVDs) and risk factors including type 1 and type 2 diabetes (T1D and T2D, respectively), obesity, chronic vascular inflammation, dyslipidemia, heart ...
Ahmed Arafa   +2 more
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Thiamine Deficiency in Mammals

2009
The use of animal models of thiamine deficiency has proved quite beneficial in the elucidation of underlying mechanisms of pathogenesis. Brain lesions, time course, symptoms, and reversibility of symptoms all correlate very well with features seen in humans. The issue of mode of action of thiamine antagonists has been investigated in thiamine-deficient
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Early Thiamine Deficiency

2009
Early thiamine deficiency studies were performed on pigeons because these birds were uniquely sensitive to polished rice. Symptoms frequently were evident by 21 days, which was as early as or earlier than any other animal model. This sensitivity also took the form of pronounced symptoms and certain death when not reversed with thiamine.
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