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Relationship of blood thiamine pyrophosphate to plasma phosphate and the response to enteral nutrition plus co-administration of intravenous thiamine during critical illness.

Journal of human nutrition and dietetics (Print), 2023
BACKGROUND Hypovitamin B1 occurs frequently during critical illness but is challenging to predict or rapidly diagnose. The objective of this study were to evaluate whether plasma phosphate concentrations predict hypovitamin B1, enteral nutrition prevents
J. Collie   +10 more
semanticscholar   +1 more source

Unraveling the Role of π-Stacking Interactions in Ligand Binding to the Thiamine Pyrophosphate Riboswitch with High-level Quantum Chemical Calculations and Docking Study.

Journal of Physical Chemistry B, 2022
The thiamine pyrophosphate (TPP) riboswitch has emerged as the new target for designing new ligands for antibiotic purpose. Binding of the natural ligand TPP to the TPP riboswitch causes downregulation of the genes responsible for its biosynthesis.
Padmaja D. Wakchaure, B. Ganguly
semanticscholar   +1 more source

Engineering Allosteric Ribozymes to Detect Thiamine Pyrophosphate in Whole Blood.

Analytical Chemistry, 2021
Thiamine deficiency contributes to several human diseases including Alzheimer's. As its biologically active form, thiamine pyrophosphate (TPP) has been considered as a potential biomarker for Alzheimer's disease (AD) based on several clinical reports ...
Xinyu Du   +6 more
semanticscholar   +1 more source

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