Results 61 to 70 of about 507,445 (265)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

New Developments in the Nondestructive Testing of Quality for Industrial Products

Механика машин, механизмов и материалов, 2012
The article shows the role of nondestructive testing and technical diagnostics in the solving problems to improve the quality and competitiveness of industrial products, the reliability and safety of complex technical systems.
N.P. Migun
doaj  

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Non-destructive method of characterizing nitrided layers in the 42CrMo4 steel using the amplitude-frequency technique of eddy currents

Open Engineering
The aim of this work was to investigate the possibility of using the eddy current method, a technique for measuring voltage amplitude and resonant frequency, for non-destructive assessment of the thickness of the near-surface layer of iron nitrides in ...
Kondej Adam, Kukla Dominik, Wach Piotr, Zagórski Andrzej   +3 more
doaj   +1 more source

Continuous ultrasonic thickness measurement technology

ITM Web of Conferences, 2017
The article describes the technologies and means of ultrasonic thickness measurement for pipeline base metal and welded joints using phased array antennas with linear scanning by TOFD and DAF methods.
Pronin Vitaliy, Shkatov Petr, Sandulyak Anna, Baskonus Haci Mehmet   +3 more
doaj   +1 more source

Development of a Transmission Line Model for the Thickness Prediction of Thin Films via the Infrared Interference Method

Technologies, 2018
An efficient transmission line model in the micrometric order is presented in this paper, to determine the thickness of thin dielectric films deposited on highly-doped substrates.
Christos Mpilitos, Stamatios Amanatiadis, Georgios Apostolidis, Theodoros Zygiridis, Nikolaos Kantartzis, Georgios Karagiannis   +5 more
doaj   +1 more source

Validity of a Wearable Digital Insole for Assessing Gait ON and OFF in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Gait impairment is a distinctive symptom of Parkinson's disease that negatively impact mobility. We assessed the validity of wearable digital insoles against a validated reference gait analysis system for measuring select gait characteristics in patients with Parkinson's disease. Methods A comparative analysis between digital insoles
Deborah A. Hall, Kimberly Kwei, Rolando J. Acosta, Bharatkumar Koyani, Erin Robertson, Pratyush Rai, Roland Barge, Emily Timm, Nicollette L. Purcell, Natasha Desai, Dhanesh Patel, Ana‐Maria Visoiu‐Knapp, Samuel Stuart, Rinol Alaj, Matthew F. Wipperman, Oren Levy, Joan A. O'Keefe   +16 more
wiley   +1 more source

An approach based on gamma-ray transmission technique and artificial neural network for accurately measuring the thickness of various materials [PDF]

Nuclear Technology and Radiation Protection
This paper presents an approach based on the gamma-ray transmission technique and artificial neural network for accurately measuring the thickness of various materials in flat sheet form.
Trang Le Thi Ngoc, Linh Nguyen Thi Truc, Thanh Tran Thien, Tam Hoang Duc, Chuong Huynh Dinh   +4 more
doaj   +1 more source