Results 1 to 10 of about 697 (107)

A metallo-β-lactamase enzyme for internal detoxification of the antibiotic thienamycin [PDF]

Scientific Reports, 2021
Thienamycin, the first representative of carbapenem antibiotics was discovered in the mid-1970s from soil microorganism, Streptomyces cattleya, during the race to discover inhibitors of bacterial peptidoglycan synthesis. Chemically modified into imipenem
Seydina M. Diene, Lucile Pinault, Sophie Alexandra Baron, Saïd Azza, Nicholas Armstrong, Linda Hadjadj, Eric Chabrière, Jean-Marc Rolain, Pierre Pontarotti, Didier Raoult   +9 more
doaj   +2 more sources

An enantioselective formal synthesis of thienamycin. [PDF]

Tetrahedron Lett
Thienamycin is a carbapenem antibiotic with potent activity against gram-negative and gram-positive bacteria. Due to its promising activity but lack of chemical stability, thienamycin serves as inspiration for new synthetic antibiotic scaffolds. In this study, we report a nine-step enantioselective formal synthesis of thienamycin. Our route utilizes an
Breunig JL, Lin YC, Pierce JG.
europepmc   +3 more sources

Etymologia: Carbapenem [PDF]

Emerging Infectious Diseases, 2019
Ronnie Henry
doaj   +2 more sources

Epidemiological, Clinical and Microbiological Characteristics of Patients with Post-Traumatic Osteomyelitis of Limb Fractures in Southwest China: A Hospital-Based Study [PDF]

Journal of Bone and Joint Infection, 2017
Objective To determine the epidemiological, clinical and microbiological characteristics, of patients with post-traumatic osteomyelitis of extremity fractures, and provide evidence-based guidelines for early diagnosis and treatment, including empiric ...
J. Peng, J. Peng, J. Peng, Y. Ren, Y. Ren, W. He, W. He, Z. Li, Z. Li, J. Yang, J. Yang, Y. Liu, Y. Liu, Z. Zheng, Z. Zheng, S. L. Kates, S. L. Kates, S. L. Kates, E. M. Schwarz, E. M. Schwarz, C. Xie, C. Xie, Y. Xu   +22 more
doaj   +1 more source

In Vitro Activity of Thienamycin [PDF]

Antimicrobial Agents and Chemotherapy, 1978
The in vitro activity of thienamycin was tested against 135 aerobic and anaerobic bacteria. The compound was highly active against resistant gram-negative bacilli and penicillin-resistant Straphylococcus aureus . The antianaerobic spectrum of the drug seemed to be comparable to that of metronidazole.
F P, Tally, N V, Jacobus, S L, Gorbach
openaire   +2 more sources

In vitro activity of N-formimidoyl thienamycin (MK0787), a crystalline derivative of thienamycin [PDF]

Antimicrobial Agents and Chemotherapy, 1980
N-Formimidoyl thienamycin (MK0787) is a derivative of thienamycin, a unique, new beta-lactam antibiotic. Its activity against 285 aerobic and facultatively anaerobic clinical isolates was compared with the activities of cephalothin, ampicillin, penicillin G, ticarcillin, and tobramycin.
V W, Horadam, J D, Smilack, C L, Montgomery, J, Werringloer   +3 more
openaire   +2 more sources

Dual RNase and β-lactamase Activity of a Single Enzyme Encoded in Archaea

Life, 2020
β-lactam antibiotics have a well-known activity which disturbs the bacterial cell wall biosynthesis and may be cleaved by β-lactamases. However, these drugs are not active on archaea microorganisms, which are naturally resistant because of the lack of β ...
Seydina M. Diene, Lucile Pinault, Nicholas Armstrong, Said Azza, Vivek Keshri, Saber Khelaifia, Eric Chabrière, Gustavo Caetano-Anolles, Jean-Marc Rolain, Pierre Pontarotti, Didier Raoult   +10 more
doaj   +1 more source

Synthese einer chiralen Thienamycin-Vorstufe / Synthesis of a Chiral Thienamycine Intermediate [PDF]

Zeitschrift für Naturforschung B, 1987
Abstract A key intermediate of Kametani’s total synthesis of racemic thienamycine has now been prepared in chiral form via a 1.3-dipolar cycloadduct of a chiral nitrone and benzyl crotonate.
Hubert Martin, Rudolf Herrmann, Ivar Ugi
openaire   +1 more source

N-formimidoyl thienamycin (MK0787): in vitro study [PDF]

Antimicrobial Agents and Chemotherapy, 1981
N-Formimidoyl thienamycin (MK0787) was compared in vitro with three other beta-lactam and two aminoglycoside antibiotics. It was second in activity only to cefotaxime against members of the Enterobacteriaceae and to amikacin against Pseudomonas species. It was the most active antibiotic against Staphylococcus aureus.
S, Shadomy, R S, May
openaire   +2 more sources

Antibacterial activities of a new stabilized thienamycin, N-formimidoyl thienamycin, in comparison with other antibiotics [PDF]

Antimicrobial Agents and Chemotherapy, 1980
The in vitro activity of a new crystalline derivative of thienamycin, N-formimidoyl thienamycin (MK0787), was tested against 46 laboratory reference strains and 2,158 clinical isolates of gram-positive and -negative bacteria, including anaerobes, and compared with cefoxitin, cefaxolin, carbenicillin, and amikacin.
T, Kesado, T, Hashizume, Y, Asahi
openaire   +2 more sources