Results 1 to 10 of about 12,794 (204)

Organic anion transporters also mediate the drug–drug interaction between imipenem and cilastatin

Asian Journal of Pharmaceutical Sciences, 2020
This study aimed to clarify that organic anion transporters (OATs) mediate the drug–drug interaction (DDI) between imipenem and cilastatin. After co-administration with imipenem, the plasma concentrations and the plasma concentration-time curve (AUC) of ...
Yanna Zhu, Xiaokui Huo, Changyuan Wang, Qiang Meng, Zhihao Liu, Huijun Sun, Aiping Tan, Xiaodong Ma, Jinyong Peng, Kexin Liu   +9 more
doaj   +3 more sources

Nephroprotective Effect of Cilastatin against Gentamicin-Induced Renal Injury In Vitro and In Vivo without Altering Its Bactericidal Efficiency

Antioxidants, 2020
Gentamicin is a used antibiotic that causes nephrotoxicity in 10–20% of treatment periods, which limits its use considerably. Our results have shown that cilastatin may be a promising therapeutic alternative in toxin-induced acute kidney injury (AKI ...
Juan Carlos Jado, Blanca Humanes, María Ángeles González-Nicolás, Sonia Camaño, José Manuel Lara, Beatriz López, Emilia Cercenado, Julio García-Bordas, Alberto Tejedor, Alberto Lázaro   +9 more
doaj   +3 more sources

Cilastatin protects against imipenem-induced nephrotoxicity via inhibition of renal organic anion transporters (OATs)

Acta Pharmaceutica Sinica B, 2019
Imipenem is a carbapenem antibiotic. However, Imipenem could not be marketed owing to its instability and nephrotoxicity until cilastatin, an inhibitor of renal dehydropeptidase-I (DHP-I), was developed.
Xiaokui Huo, Qiang Meng, Changyuan Wang, Yanna Zhu, Zhihao Liu, Xiaodong Ma, Xiaochi Ma, Jinyong Peng, Huijun Sun, Kexin Liu   +9 more
doaj   +3 more sources

Case Report: Delayed-type hypersensitivity reaction to meropenem in an elderly patient—successful management with imipenem-cilastatin [PDF]

Frontiers in Medicine
Meropenem is a clinically essential carbapenem antibiotic with a broad antimicrobial spectrum, potent antibacterial efficacy, and high stability against β-lactamase, which plays a pivotal role in anti-infective therapy.
Cuilin He, Maozhu Liu, Jiao Ye, Hong Zheng, Junjie Yang, Lingmei Huang   +5 more
doaj   +2 more sources

Empiric Imipenem/Cilastatin/Relebactam for Febrile Neutropenia After Allogeneic Hematopoietic Stem Cell Transplantation: Two Case Reports [PDF]

Journal of Blood Medicine
Dao-Xing Deng,* Ting Wang,* Hui Sun,* Jun Kong, Yuan-Yuan Zhang, Le-Qing Cao, Xiao-Dong Mo Department of Hematology, Peking University People’s Hospital, Peking University Institute of Hematology, National Clinical Research Center
Deng DX, Wang T, Sun H, Kong J, Zhang YY, Cao LQ, Mo XD   +6 more
doaj   +2 more sources

Cilastatin Modulates DPEP1- and IQGAP1-Associated Neuro-Glio-Vascular Inflammation in Oxaliplatin-Induced Peripheral Neurotoxicity [PDF]

Cells
Oxaliplatin-induced peripheral neurotoxicity (OIPN) represents a major challenge in cancer therapy, characterized by dorsal root ganglia (DRG) inflammation and disruption of neuro-glio-vascular unit function.
Rita Martín-Ramírez, María Ángeles González-Nicolás, Karen Álvarez-Tosco, Félix Machín, Julio Ávila, Manuel Morales, Alberto Lázaro, Pablo Martín-Vasallo   +7 more
doaj   +2 more sources

Molecular characterization of carbapenem-resistant Enterobacterales (CRE) and in vitro activity of novel beta lactams against CRE isolates from Malaysia [PDF]

Microbiology Spectrum
Knowledge gap on the susceptibility of novel β-lactam agents (cefiderocol, ceftazidime-avibactam, imipenem-cilastatin-relebectam, and aztreonam) against carbapenem-resistant Enterobacterales (CRE) has been recognized.
Fairuz Abdul Rashid, Nurzam Suhaila Che Hussin, Nurul Fathiyah Zaipul Anuar, Noraziah Sahlan, Navindra Kumari Palanisamy, Fadzilah Mohd Nor   +5 more
doaj   +2 more sources

FKBP51, AmotL2 and IQGAP1 Involvement in Cilastatin Prevention of Cisplatin-Induced Tubular Nephrotoxicity in Rats

Cells, 2022
The immunophilin FKBP51, the angiomotin AmotL2, and the scaffoldin IQGAP1 are overexpressed in many types of cancer, with the highest increase in leucocytes from patients undergoing oxaliplatin chemotherapy.
Rebeca González-Fernández, María Ángeles González-Nicolás, Manuel Morales, Julio Ávila, Alberto Lázaro, Pablo Martín-Vasallo   +5 more
doaj   +1 more source

Imipenem–cilastatin-induced thrombocytosis: A probable rare case report

European Journal of Inflammation, 2022
Drug-induced thrombocytosis is difficult to identify and is rarely reported. Here, we report a probable rare case of imipenem–cilastatin-induced thrombocytosis in a 51-year-old female.
Huadong Chen, Xing’e Xu, Piaopiao Li, Zhenglin Xu   +3 more
doaj   +1 more source

Identification of Antibiotics in Surface-Groundwater. A Tool towards the Ecopharmacovigilance Approach: A Portuguese Case-Study

Antibiotics, 2021
Environmental monitoring, particularly of water, is crucial to screen and preselect potential hazardous substances for policy guidance and risk minimisation strategies. In Portugal, extensive data are missing.
Paula Viana, Leonor Meisel, Ana Lopes, Rosário de Jesus, Georgina Sarmento, Sofia Duarte, Bruno Sepodes, Ana Fernandes, Margarida M. Correia dos Santos, Anabela Almeida, M. Conceição Oliveira   +10 more
doaj   +1 more source