Results 1 to 10 of about 78,162 (300)

Association of high intra-patient variability in tacrolimus exposure with calcineurin inhibitor nephrotoxicity in kidney transplantation

Scientific Reports, 2023
Tacrolimus intra-patient variability (IPV) is a novel predictive marker for long-term kidney transplantation outcomes. We examined the association between IPV and calcineurin inhibitor (CNI) nephrotoxicity and the impact of pharmacogenes on CNI ...
Hyokee Kim, Ahram Han, Sanghyun Ahn, Seung-Kee Min, Jongwon Ha, Sangil Min   +5 more
doaj   +1 more source

Melatonin improves mitochondrial function by preventing mitochondrial fission in cadmium-induced rat proximal tubular cell injury via SIRT1–PGC-1α pathway activation

Ecotoxicology and Environmental Safety, 2022
Melatonin is an indoleamine produced in the pineal gland and has many physiological roles. There is increasing evidence that melatonin ameliorates cadmium (Cd)-induced nephrotoxicity.
Wenxuan Dong, Lianqi Yan, Yun Tan, Shufang Chen, Kanglei Zhang, Zhonggui Gong, Wenjing Liu, Hui Zou, Ruilong Song, Jiaqiao Zhu, Gang Liu, Zongping Liu   +11 more
doaj   +1 more source

Genetic polymorphisms of TRPA1 does affect risk of cisplatin induced nephrotoxicity in Chinese population

Translational Oncology
Introduction: Irreversible acute kidney injury (AKI) caused by cisplatin limits its clinical use, and transient receptor potential anchor protein 1 (TRPA1) regulates cisplatin-induced nephrotoxicity (CIN) through NF-κB signaling pathway-mediated ...
Cong Wang, Guifei Deng, Siyu Niu, Xianglong Meng   +3 more
doaj   +1 more source

Predictive usefulness of urinary biomarkers for the identification of cyclosporine A-induced nephrotoxicity in a rat model.

PLoS ONE, 2014
The main side effect of cyclosporine A (CsA), a widely used immunosuppressive drug, is nephrotoxicity. Early detection of CsA-induced acute nephrotoxicity is essential for stop or minimize kidney injury, and timely detection of chronic nephrotoxicity is ...
Carla Patrícia Carlos, Nathália Martins Sonehara, Sonia Maria Oliani, Emmanuel A Burdmann   +3 more
doaj   +1 more source

Vancomycin dosing design method considering risk factors for nephrotoxicity

Journal of Pharmaceutical Health Care and Sciences
Background Vancomycin (VCM) induces nephrotoxicity in a dose-dependent manner, and patients with risk factors for nephrotoxicity have been reported to develop nephrotoxicity even within the effective concentration range.
Yoshihiko Matsuki, Yutaro Kozima, Megumi Yanagi, Ken-ichi Sako, Tamaki Watanabe, Nobuhiro Yasuno, Shigekazu Watanabe   +6 more
doaj   +1 more source

Precision nephrotoxicity testing using 3D in vitro models

Cell & Bioscience, 2023
Nephrotoxicity is a significant concern during the development of new drugs or when assessing the safety of chemicals in consumer products. Traditional methods for testing nephrotoxicity involve animal models or 2D in vitro cell cultures, the latter of ...
Pengfei Yu, Hainan Zhu, Carol Christine Bosholm, Daniella Beiner, Zhongping Duan, Avinash K. Shetty, Steve S. Mou, Philip Adam Kramer, Luis F. Barroso, Hongbing Liu, Kun Cheng, Michael Ihnat, Matthew A. Gorris, Joseph A. Aloi, Jobira A. Woldemichael, Anthony Bleyer, Yuanyuan Zhang   +16 more
doaj   +1 more source

Genetic Variations and Cisplatin Nephrotoxicity: A Systematic Review

Frontiers in Pharmacology, 2018
Background: Nephrotoxicity is a notable adverse effect in cisplatin treated patients characterized by tubular injury and/or increased serum creatinine (SCr) with incidence varying from 20 to 70%.
Zulfan Zazuli, Zulfan Zazuli, Susanne Vijverberg, Elise Slob, Geoffrey Liu, Geoffrey Liu, Bruce Carleton, Bruce Carleton, Bruce Carleton, Joris Veltman, Paul Baas, Paul Baas, Rosalinde Masereeuw, Anke-Hilse Maitland-van der Zee   +13 more
doaj   +1 more source

The Renin-Angiotensin System Involvement in Cisplatin-Induced Nephrotoxicity: An Overview of Physiological and Pathological Mechanisms—A Systematic Review

International Journal of Nephrology
Cisplatin (CDDP) is a highly potent chemotherapy drug. But its nephrotoxicity poses a significant limitation to its use. The renin-angiotensin system (RAS) has been proposed to play a role in drug-induced nephrotoxicity.
Aryan Vakilian, Sina Mohammadi, Fatemeh Shokri, Maryam Maleki, Maryam Kheiry, Amin Kheiri   +5 more
doaj   +1 more source

Prevalence and Risk Factors of Nephrotoxicity Among Adult Cancer Patients at Mbarara Regional Referral Hospital

Cancer Management and Research, 2021
John Isiiko,1– 3 Barnabas Atwiine,4 Joseph Oloro5 1Department of Pharmacy, Mbarara University of Science and Technology, Mbarara, Uganda; 2Pharmacy Biotechnology and Traditional Medicine Center, Mbarara University of Science and Technology, Mbarara ...
Isiiko J, Atwiine B, Oloro J
doaj  

Nephrotoxicity and ototoxic symptoms of injectable second-line anti-tubercular drugs among patients treated for MDR-TB in Ethiopia: a retrospective cohort study

BMC Pharmacology and Toxicology, 2019
Background Nephrotoxicity and ototoxicity are clinically significant dose-related adverse effects associated with second-line anti-tubercular injectables drugs (aminoglycosides and capreomycin) used during intensive phase of treatment of multi-drug ...
Workineh Shibeshi, Anandi N. Sheth, Addisu Admasu, Alemseged Beyene Berha, Zenebe Negash, Getnet Yimer   +5 more
doaj   +1 more source