Results 11 to 20 of about 72,055 (308)
Bisphosphonate nephrotoxicity [PDF]
Kidney International, 2008 Bisphosphonates are valuable agents for the treatment of post-menopausal osteoporosis (PMO), hypercalcemia of malignancy, and osteolytic bone metastases. Oral bisphosphonates are used mainly to treat PMO and are not associated with significant nephrotoxicity.
Perazella, Mark A., Markowitz, Glen S.
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Experimental Cell Line Models for Nephrotoxicity Screening [PDF]
Регуляторные исследования и экспертиза лекарственных средств, 2021 The aim of the study was to review literature data on cell models for experimental assessment of drug nephrotoxicity in vitro. Because of nephrotoxicity, 2% of new investigational medicinal products are discarded at the stage of preclinical in vivo ...
I. A. Mazerkina +4 more
doaj +3 more sources
Risk factors for calcineurin inhibitor nephrotoxicity after renal transplantation: a systematic review and meta-analysis [PDF]
Drug Design, Development and Therapy, 2018 Tianyi Xia, Sang Zhu, Yan Wen, Shouhong Gao, Mingming Li, Xia Tao, Feng Zhang, Wansheng Chen Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai, People’s Republic of China Background: Nephrotoxicity of ...
Xia T +7 more
doaj +1 more source
AIDS Research and Treatment, 2011 Highly active antiretroviral therapy (HAART) and other medical therapies for HIV-related infections have been associated with toxicities. Antiretroviral therapy can contribute to renal dysfunction directly by inducing acute tubular necrosis, acute interstitial nephritis, crystal nephropathy, and renal tubular disorders or indirectly via drug ...
Robert Kalyesubula, Mark A. Perazella
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F1000Research, 2017 Nephrotoxic medication exposure is nearly ubiquitous in hospitalized patients and represents one of the most common causes of acute kidney injury (AKI) in the hospitalized setting. Although provision of medications that are nephrotoxic has led to improved outcomes in terms of treatment of underlying illness, unnecessary nephrotoxic medication exposure ...
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The Nephrotoxicity of Vancomycin [PDF]
Clinical Pharmacology & Therapeutics, 2017 Vancomycin use is often associated with nephrotoxicity. It remains uncertain, however, to what extent vancomycin is directly responsible, as numerous potential risk factors for acute kidney injury frequently coexist. Herein, we critically examine available data in adult patients pertinent to this question.
Filippone, Edward J. +2 more
openaire +2 more sources
Proteomic candidate biomarkers of drug-induced nephrotoxicity in the rat [PDF]
, 2012 Improved biomarkers of acute nephrotoxicity are coveted by the drug development industry, regulatory agencies, and clinicians. In an effort to identify such biomarkers, urinary peptide profiles of rats treated with two different nephrotoxins were ...
Hanig, J. +23 more
core +1 more source
MIT-LCP/vancomycin-nephrotoxicity: Vancomycin Nephrotoxicity in eICU [PDF]
, 2020 Initial release of the code behind a study on broad spectrum antibiotic use in the eRI Research Database.
Miguel Armengol de la Hoz +3 more
core +1 more source
Mechanisms of calcineurin inhibitor nephrotoxicity in chronic allograft injury [PDF]
, 2012 The first successful transplantation of a human kidney was performed more than 50 years ago by Murray and colleagues in 1954 between identical twins. The success of this transplantation was due to the fact that no significant rejection occurs between ...
Ryan, Michael P. +10 more
core +2 more sources
Journal of Global Antimicrobial Resistance, 2021 : Objectives: Colistin, an important drug to treat carbapenem-resistant Acinetobacter baumannii (CRAB) infections, has a narrow therapeutic window with nephrotoxicity.
Yun-Jeong Jeong +5 more
doaj +1 more source