Results 41 to 50 of about 12,794 (204)

Prophylaxis and antibiotic therapy in management protocols of patients treated with oral and intravenous bisphosphonates [PDF]

open access: yes, 2017
Osteonecrosis of the jaw (MRONJ) linked to bisphosphonate treatment has specific characteristics that render its therapeutic management challenging for clinicians.
Bermúdez Bejarano, Elena Beatriz   +6 more
core   +1 more source

Imipenem/Cilastatin versus Cefepime as Empiric Monotherapy for Fever in Neutropenic Patients after ematopoietic Stem Cell Transplantation [PDF]

open access: yesInternational Journal of Hematology-Oncology and Stem Cell Research, 2005
Objective: To evaluate the potential advantages of imipenem/cilastatin in control of fever in neutro-penic HSCT recipients.Patients and Method: In this single-center study, 111 consecutive febrile episodes in 104 neutropenic HSCT recipients with a mean ...
C Kani   +6 more
doaj   +1 more source

Automated Detection of Systematic Off-label Drug Use in Free Text of Electronic Medical Records. [PDF]

open access: yes, 2013
Off-label use of a drug occurs when it is used in a manner that deviates from its FDA label. Studies estimate that 21% of prescriptions are off-label, with only 27% of those uses supported by evidence of safety and efficacy.
Jung, Kenneth   +2 more
core   +2 more sources

Evaluation of the Surgical and Pharmacological Treatment of Diabetic Foot Infection: A Retrospective Study [PDF]

open access: yes, 2017
BACKGROUND: Diabetic foot infection is a major cause of patient disabilities and lowers limb amputations, with high treatment costs and hospitalisation requirements.
Aliakbar, Adil Hassan   +2 more
core   +4 more sources

Nontherapeutic equivalence of a generic product of imipenem-cilastatin is caused more by chemical instability of the active pharmaceutical ingredient (imipenem) than by its substandard amount of cilastatin.

open access: yesPLoS ONE, 2019
BACKGROUND:We demonstrated therapeutic nonequivalence of "bioequivalent" generics for meropenem, but there is no data with generics of other carbapenems.
Maria Agudelo   +3 more
doaj   +1 more source

Epidemiology, Management, and Alarmingly High Mortality of Burn Patients: A Retrospective Analysis From a Resource‐Limited Tertiary Centre in Syria

open access: yesInternational Wound Journal, Volume 23, Issue 4, April 2026.
ABSTRACT Burn injuries pose a significant challenge in resource‐limited settings, particularly during humanitarian crises. This study examines the epidemiology, management, and outcomes of burn patients at a tertiary hospital in Damascus, Syria, from 2021 to 2024.
Lorieh Domat   +6 more
wiley   +1 more source

Effective antibiotic conservation by emergency antimicrobial stewardship during a drug shortage [PDF]

open access: yes, 2016
We present the first description of an antimicrobial stewardship program (ASP) used to successfully manage a multi-antimicrobial drug shortage. Without resorting to formulary restriction, meropenem utilization decreased by 69% and piperacillin-tazobactam
Casabar, Ed   +8 more
core   +2 more sources

Postpartum Necrotizing Myometritis

open access: yesClinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT We present a case of postpartum necrotizing myometritis, a rare complication that often occurs following transcatheter arterial embolization for the treatment of postpartum hemorrhage, and its etiology is closely associated with uterine ischemia and bacterial infection.
Jiangyan Xie
wiley   +1 more source

Nephroprotective Effects of Cilastatin in People at Risk of Acute Kidney Injury: A Systematic Review and Meta-analysis

open access: yesKidney Medicine
Rationale & Objective: Cilastatin is an inhibitor of drug metabolism in the proximal tubule that demonstrates nephroprotective effects in animals.
Dilaram Acharya   +9 more
doaj   +1 more source

Efficacy and safety of tigecycline monotherapy vs. imipenem/cilastatin in Chinese patients with complicated intra-abdominal infections: a randomized controlled trial

open access: yesBMC Infectious Diseases, 2010
Background Tigecycline, a first-in-class broad-spectrum glycylcycline antibiotic, has broad-spectrum in vitro activity against bacteria commonly encountered in complicated intra-abdominal infections (cIAIs), including aerobic and facultative Gram ...
Chen Xiaoping   +15 more
doaj   +1 more source

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