Empiric antibiotic therapy in the treatment of community-acquired pneumonia in a general hospital in Saudi Arabia [PDF]
Journal of Global Infectious Diseases, 2019 Background: Guideline-based empiric antimicrobial therapy is recommended for the treatment of community-acquired pneumonia (CAP). In this study, we evaluate the pattern of empiric antibiotics of CAP patients. Materials and Methods: Patients with CAP were
Jaffar A Al-Tawfiq +2 more
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Evaluation of the appropriateness of imipenem/cilastatin prescription and dosing in a tertiary care hospital [PDF]
Infection and Drug Resistance, 2015 Wissam K Kabbara, George T Nawas, Wijdan H RamadanDepartment of Pharmacy Practice, School of Pharmacy, Lebanese American University, Byblos, Lebanon Background: Imipenem/cilastatin is an antibacterial agent of the carbapenem class of β-lactams that
Kabbara WK, Nawas GT, Ramadan WH
doaj +3 more sources
Spatially Characterized Aortic Proteome Reveals Novel Regional Signatures and Glucocorticoid Receptor/Dipeptidase 1 Axis in Diabetic Vasculopathy. [PDF]
MedComm (2020)This study presents the first spatially resolved proteomic map of diabetic vasculopathy, identifying distinct molecular signatures in aortic regions. The glucocorticoid receptor/dipeptidase 1 (GR/DPEP1) axis was identified as a novel driver of diabetic vascular inflammation and dysfunction.
Cheng CK +9 more
europepmc +2 more sources
Wasp venom-induced acute kidney injury: current progress and prospects
Renal Failure, 2023 Wasp venom can trigger local and systemic reactions, with the kidneys being commonly affected, potentially causing acute kidney injury (AKI). Despite of the recent advances, our knowledge on the underlying mechanisms of toxicity and targeted therapies ...
Fanglin Yu +5 more
doaj +1 more source
Scientific Reports, 2021 Cisplatin, one of the most active anticancer agents, is widely used in standard chemotherapy for various cancers. Cisplatin is more poorly tolerated than other chemotherapeutic drugs, and the main dose-limiting toxicity of cisplatin is its nephrotoxicity,
Masashi Arita +21 more
doaj +1 more source
Cilastatin Attenuates Cisplatin-Induced Proximal Tubular Cell Damage [PDF]
, 2010 A major area in cancer therapy is the search for protective strategies against cisplatin-induced nephrotoxicity. We investigated the protective effect of cilastatin on cisplatininduced injury to renal proximal tubular cells.
Bosca, Lisardo +9 more
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The Surgical Infection Society revised guidelines on the management of intra-abdominal infection [PDF]
, 2017 Background: Previous evidence-based guidelines on the management of intra-abdominal infection (IAI) were published by the Surgical Infection Society (SIS) in 1992, 2002, and 2010. At the time the most recent guideline was released, the plan was to update
Chang, Phillip K +11 more
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Successful Treatment of Acute Prostatitis Caused by Multidrug-Resistant Escherichia coli With Tigecycline Monotherapy [PDF]
, 2020 We present a successful treatment, with tigecycline monotherapy, of acute prostatitis caused by multidrug-resistant Escherichia coli harboring an NDM-1 carbapemenase along with a CMY-2 cephalosporinase and a TEM ...
Babouee Flury, Baharak +7 more
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Tigecycline is efficacious in the treatment of complicated intra-abdominal infections [PDF]
, 2005 Background Empiric treatment of complicated intra-abdominal infections (cIAI) represents a clinical challenge because of the diverse bacteriology and the emergence of bacterial resistance. The efficacy and safety of tigecycline (TGC), a first-in-class,
Barauskas, Giedrius +5 more
core +1 more source
Asian Journal of Surgery, 2004 Treatment of intra-abdominal infections remains a challenge because of their polymicrobial nature and associated mortality risk. Broad-spectrum empiric coverage is usually required.
Alex A. Erasmo
doaj +1 more source