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In vitro activity of thienamycin.
Methods and findings in experimental and clinical pharmacology, 1982The in vitro activity of thienamycin was determined simultaneously in Müller-Hinton broth and peptone broth. Minimum inhibitory and bactericidal concentrations were compared to those of 4 aminoglycosides and 3 cefalosporins. The activity of thienamycin against gram-negative aerobic bacterial was influenced by the media.
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[N-Formimidoyl-thienamycin in Animal Studies].
Arzneimittel-Forschung, 1983The beta-lactam antibiotic thienamycin is rather unstable and is metabolized in man by renal dehydropeptidase-I. The derivatives of the antibiotic, especially N-formimidoyl-thienamycin (MK-0787) are reported to be more resistant. The antibacterial activity of N-formimidoyl-thienamycin was tested by means of the infection- and therapy model of the acute,
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Thienamycin total synthesis. 3. Total synthesis of (.+-.)-thienamycin and (.+-.)-8-epithienamycin
The Journal of Organic Chemistry, 1980Susan M. Schmitt +2 more
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Total synthesis of (.+-.)-thienamycin
Journal of the American Chemical Society, 1978David B. R. Johnston +3 more
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Asymmetric Synthesis of (+)-Thienamycin
HETEROCYCLES, 1983Shiro Ikegami +2 more
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A stereocontrolled synthesis of (+)-thienamycin
Journal of the American Chemical Society, 1980Thomas N. Salzmann +3 more
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