Results 11 to 20 of about 697 (107)

International consensus recommendations for the use of prolonged‐infusion beta‐lactam antibiotics: Endorsed by the American College of Clinical Pharmacy, British Society for Antimicrobial Chemotherapy, Cystic Fibrosis Foundation, European Society of Clinical Microbiology and Infectious Diseases, Infectious Diseases Society of America, Society of Critical Care Medicine, and Society of Infectious Diseases Pharmacists

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 43, Issue 8, Page 740-777, August 2023., 2023
Abstract Intravenous β‐lactam antibiotics remain a cornerstone in the management of bacterial infections due to their broad spectrum of activity and excellent tolerability. β‐lactams are well established to display time‐dependent bactericidal activity, where reductions in bacterial burden are directly associated with the time that free drug ...
Lisa T. Hong, Kevin J. Downes, Alireza FakhriRavari, Jacinda C. Abdul‐Mutakabbir, Joseph L. Kuti, Sarah Jorgensen, David C. Young, Mohammad H. Alshaer, Matteo Bassetti, Robert A. Bonomo, Mark Gilchrist, Soo Min Jang, Thomas Lodise, Jason A. Roberts, Thomas Tängdén, Athena Zuppa, Marc H. Scheetz   +16 more
wiley   +1 more source

Dissemination of carbapenemase‐producing Enterobacteriaceae and associated resistance determinants through global food systems

Comprehensive Reviews in Food Science and Food Safety, Volume 22, Issue 4, Page 2706-2727, July 2023., 2023
Abstract Antimicrobial agents are a critical component of modern healthcare systems, fulfilling a core function in patient care and improving individual patient outcomes and consequently overall public health. However, the efficacy of antimicrobial interventions is being consistently eroded by the emergence and dissemination of various antimicrobial ...
Richard Harding‐Crooks, Darren Smith, Séamus Fanning, Edward M. Fox   +3 more
wiley   +1 more source

Environmental hotspots for antibiotic resistance genes

MicrobiologyOpen, Volume 10, Issue 3, June 2021., 2021
Antibiotic contamination or waste enters a variety of different environmental settings. The accumulation of antibiotics ​can cause a selective pressure on bacteria that encode resistance genes for their survival, generating a hotspot for resistance genes.
Shalini Kunhikannan, Colleen J. Thomas, Ashley E. Franks, Sumana Mahadevaiah, Sumana Kumar, Steve Petrovski   +5 more
wiley   +1 more source

Imipenem and Meropenem: Comparison of In Vitro Activity, Pharmacokinetics, Clinical Trials and Adverse Effects

Canadian Journal of Infectious Diseases and Medical Microbiology, Volume 9, Issue 4, Page 215-228, 1998., 1997
OBJECTIVE: To compare and contrast imipenem and meropenem in terms of in vitro activity, pharmacokinetics, clinical efficacy and adverse effects. DATA SELECTION: MEDLINE search from 1975 to 1997 and follow‐up of references. DATA EXTRACTION: Clinical trials comparing imipenem with meropenem, or either imipenem or meropenem with standard therapy in the ...
George G Zhanel, Andrew E Simor, Lavern Vercaigne, Lionell Mandell, the Canadian Carbapenem Discussion Group   +4 more
wiley   +1 more source

Methionine inhibition of thienamycin formation

Journal of Industrial Microbiology, 1988
Methionine interference in the formation of thienamycin byStreptomyces cattleya is due, to a major extent, to inhibition of enzyme activity.
Masaru Uyeda, Arnold L. Demain
openaire   +1 more source

Canadian Practice Guidelines for Surgical Intra‐Abdominal Infections

, 2010
Canadian Journal of Infectious Diseases and Medical Microbiology, Volume 21, Issue 1, Page 11-37, 2010.
Anthony W Chow, Gerald A Evans, Avery B Nathens, Chad G Ball, Glen Hansen, Godfrey KM Harding, Andrew W Kirkpatrick, Karl Weiss, George G Zhanel   +8 more
wiley   +1 more source

Access to β‐Lactam Sulfonamides from Sulfamoyl Chlorides via Photoredox Catalyzed C−S Bond Formation

Advanced Synthesis &Catalysis, Volume 366, Issue 15, Page 3310-3315, August 6, 2024.
Abstract Sulfonyl chlorides are a synthetically attractive source of sulfonyl radicals in photoredox catalysis and are useful precursors in the synthesis of sulfones. Sulfamoyl chlorides, on the other hand, remain poorly represented despite their similar potential.
Nejc Petek, Helena Brodnik, Uroš Grošelj, Jurij Svete, Bogdan Štefane   +4 more
wiley   +1 more source

In vitro activity of N-formimidoyl thienamycin (MK0787) [PDF]

Antimicrobial Agents and Chemotherapy, 1980
The in vitro activity of N-formimidoyl thienamycin (MK0787), a stable congener of thienamycin, was determined against 200 species of aerobic and 84 species of anaerobic bacteria. The compound was highly active against resistant gram-negative bacilli, penicillin-resistant Staphylococcus aureus, enterococci, and anaerobic bacteria.
F P, Tally, N V, Jacobus, S L, Gorbach
openaire   +2 more sources

Total syntheses of bioactive natural products from carbohydrates

Science and Technology of Advanced Materials, 2006
Total syntheses of bioactive natural products recently accomplished in our laboratories are described. They are classified by structures of target molecules and are focused on our original approach to their own structures.
Kuniaki Tatsuta and Seijiro Hosokawa
doaj  

Urinary Recovery of N -Formimidoyl Thienamycin (MK0787) as Affected by Coadministration of N -Formimidoyl Thienamycin Dehydropeptidase Inhibitors [PDF]

Antimicrobial Agents and Chemotherapy, 1983
N -Formimidoyl thienamycin (MK0787) undergoes renal metabolism by a dipeptidase, dehydropeptidase I, located on the brush border of the proximal tubular cells. The effects of two inhibitors (MK-789 and MK-791) of dehydropeptidase I on the pharmacokinetics of N -formimidoyl thienamycin were studied in 41 ...
S R, Norrby, K, Alestig, B, Björnegård, L A, Burman, F, Ferber, J L, Huber, K H, Jones, F M, Kahan, J S, Kahan, H, Kropp, M A, Meisinger, J G, Sundelof   +11 more
openaire   +2 more sources