A formal total asymmetric synthesis of (+)-thienamycin
Tetrahedron: Asymmetry, 1995 Abstract Synthesis of an enantiomerically pure intermediate to (+)-thienamycin is presented: the pivotal reaction in this sequence is the highly diastereoselective Michael addition of a differentially protected lithium amide.
Davies, S, Hedgecock, C, Mckenna, J
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Journal of Industrial Microbiology, 1987 A cell-free extract from the thienamycin producer,Streptomyces cattleya, has been found to deacetylate the co-product,N-acetylthienamycin. The pH optimum of the reaction is 7.5. Due to the lability ofN-acetylthienamycin, we used thed andl forms of the synthetic substrateN-chloroacetylvaline.
Masaru Uyeda, Arnold L. Demain
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