Results 81 to 90 of about 697 (107)

ChemInform Abstract: Asymmetric Synthesis of (+)‐Thienamycin.

Chemischer Informationsdienst, 1983
AbstractEs wird ein Syntheseweg angegeben für die Umwandlung des Propargyl‐azetidinons (I) zum Thienamycin‐Vorprodukt (II).
M. SHIBASAKI, A. NISHIDA, S. IKEGAMI
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Continuous production of thienamycin in immobilized cell systems

Biotechnology and Bioengineering, 1986
AbstractA novel 2‐L bubble column was used to study the continuous, immobilized cell production of thienamycin. Cells of Streptomyces cattleya were immobilized by culturing them in an appropriate growth medium containing 60/80 mesh celite particles. The dilution rate used during the continuous growth phase was 0.2 h−1.
E J, Arcuri, G, Slaff, R, Greasham
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ChemInform Abstract: TOTAL SYNTHESIS OF (.+‐.)‐THIENAMYCIN

Chemischer Informationsdienst, 1978
AbstractDas aus 1‐Acetoxy‐butadien mit Chlorsulfonylisocyanat erhaltene Acetidinon (Ia) gibt bei reduktiver Hydrolyse (H2O, K,HPO4, Na,SO3, 0°C) (Ib) (42% Gesamtausb.).
D. B. R. JOHNSTON, S. M. SCHMITT, F. A. BOUFFARD, B. G. CHRISTENSEN   +3 more
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A stereocontrolled, enantiomerically specific total synthesis of thienamycin

Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1980
A versatile stereocontrolled total synthesis of thienamycin starting from L-aspartic acid is reported. Stereocontrol is achieved by potassium tri- sec -butylborohydride reduction of a thermodynamically formed 3α-acetylazetidinone intermediate.
T N, Salzmann, R W, Ratcliffe, F A, Bouffard, B G, Christensen   +3 more
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ChemInform Abstract: TOTAL SYNTHESIS OF THIENAMYCIN ANALOGS. 1. SYNTHESIS OF THE THIENAMYCIN NUCLEUS AND DL‐DECYSTEAMINYLTHIENAMYCIN

Chemischer Informationsdienst, 1979
AbstractAusgehend von dem Azetidinon (I) bzw. dem Oxaazabicyclooctanon (Va) wird das Carbapenem‐carboxylat (IVb) bzw. das dl‐Descysteaminylthienamycinsalz dl‐(VIIIb) synthetisiert.
L. D. CAMA, B. G. CHRISTENSEN
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ChemInform Abstract: THIENAMYCIN TOTAL SYNTHESIS. 1. SYNTHESIS OF AZETIDINONE PRECURSORS OF (.+‐.)‐THIENAMYCIN AND ITS STEREOISOMERS

Chemischer Informationsdienst, 1980
AbstractIm Zusammenhang mit der Synthese des antibiotisch wirksamen Thienamycins (XIV) werden verschiedene Modellreaktionen beschrieben.
F. A. BOUFFARD, D. B. R. JOHNSTON, B. G. CHRISTENSEN   +2 more
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Antibacterial Activity of Imipenem: The First Thienamycin Antibiotic

Clinical Infectious Diseases, 1985
Imipenem (N-formimidoyl thienamycin) is the first representative of a new class of beta-lactam antibiotics--the carbapenems. Imipenem has an unusually broad spectrum, high potency, and no cross-resistance with other beta-lactam antibiotics. Susceptible gram-negative species include Pseudomonas aeruginosa, Serratia, and Enterobacter.
H, Kropp, L, Gerckens, J G, Sundelof, F M, Kahan   +3 more
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Thienamycin. A solution of the stereochemical problem

Tetrahedron Letters, 1979
Abstract A new nitrone-based synthesis of β-lactams is described which makes provision for the 1-hydroxyethyl moiety in the potent antibiotic thienamycin. Moreover, the relative stereochemical features of the natural product are defined in a step involving the cycloaddition of a nitrone with methyl crotonate.
Joseph J. Tufariello, George E. Lee, Pushpananda A. Senaratne, Mohammed Al-Nuri   +3 more
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Imipenem: The First Thienamycin Antibiotic

Clinical Infectious Diseases, 1985
A M, Geddes, W, Stille
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Imipenem: the first thienamycin antibiotic.

Postgraduate medical journal, 1987
Imipenem is a new beta-lactam which differs chemically from penicillins and cephalosporins but has a similar mode of action. It is a potent antibacterial agent with a broad spectrum of activity encompassing both aerobes and anaerobes. However, in vitro, it does not appear to offer a great improvement over other available agents for the treatment of ...
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