Results 141 to 150 of about 33,429 (217)

Discovery of CRBN‐based molecular glue degraders targeting WIZ transcription factor

Bulletin of the Korean Chemical Society, EarlyView.
This work reports the discovery of 9l, a novel cereblon‐based molecular glue degrader which targets the WIZ transcription factor. Compound 9l facilitates WIZ‐CRBN ternary complex formation to degrade WIZ, subsequently inducing γ‐globin expression in HUDEP‐2 cells and highlighting its potential as a sickle cell disease therapy.
Tae‐Jun Kim, Seongu Seong, Jung‐Ae Kim, Taeyeon Kwon, Hyun Jin Kim, Jeong‐Hoon Kim, Jong Yeon Hwang, Jin Hwa Cho, Kyoungmin Choi   +8 more
wiley   +1 more source

Exploration of structure–activity relationship of 2,4‐diaminopyrimidine derivatives as hematopoietic progenitor kinase 1 inhibitors

Bulletin of the Korean Chemical Society, EarlyView.
Targeting HPK1 is a promising strategy to restore T‐cell anti‐tumor immunity. We report the design and synthesis of novel 2,4‐diaminopyrimidine derivatives, focusing on systematic structure–activity relationship (SAR) analysis These findings identify key structural features for potent HPK1 inhibition, facilitating the discovery of next‐generation ...
Heechan Shin, Mi‐Ran Byun, Joon Seok Choi, Sujin Lee   +3 more
wiley   +1 more source

Separation of cholesterol and desmosterol by thin-layer chromatography

Journal of Lipid Research, 1964
Lila Wolfman, Bernard A. Sachs
doaj   +1 more source

Microtopography enhances intestinal drug absorption via Piezo1‐mediated tight junction modulation

BMEMat, EarlyView.
Microtopography‐driven enhancement of oral peptide drug delivery by activating Piezo1 channels significantly improves paracellular permeability and bioavailability, offering a novel approach for optimizing macromolecule absorption in pharmaceutical formulations.
Yu Hu, Nan Xu, Xin Li, Xiaowo Kang, Tieyuan Bian, Junsheng Lin, Hao Tang, Yinyin Bao, Lu Zhang, Hongyan Yuan, Mingxi Yao, Xingyu Jiang, Zhi Luo   +12 more
wiley   +1 more source

Marine silicon for biomedical sustainability

BMEMat, EarlyView.
Schematic illustrating marine silicon for biomedical engineering. Abstract Despite momentous divergence from oceanic origin, human beings and marine organisms exhibit elemental homology through silicon utilization. Notably, silicon serves as a critical constituent in multiple biomedical processes.
Yahui Han, Zhibo Yang, Wei Xia, Chengtie Wu   +3 more
wiley   +1 more source

Atomically precise metal cluster enzymes for pathological tissue regeneration

BMEMat, EarlyView.
Schematic illustration of atomically precise metal cluster enzymes (MCEs) for pathological tissue regeneration. Atomically precise MCEs can modulate biological processes, such as attenuation of inflammatory responses, eradication of bacterial pathogens, regulation of angiogenesis, and promotion of cell development.
Ziqiang Xiong, Zhifeng Shi, Mengqing Li, Jien Han, Haoyan Chen, Maofei Ran, Shaojian Zhong, Limin Ma, Chengyun Ning, Youzhun Fan, Zhenghua Tang, Peng Yu   +11 more
wiley   +1 more source

Carbon‐Supported Dual‐Nickel Atom Catalysts With Stabilized Ni─N3 Active Sites for Efficient CO2 Electroreduction

Carbon Energy, EarlyView.
Dual‐nickel atom catalysts (Ni‐DACs) are developed to stabilize unsaturated Ni─N3 atomic sites by constructing N3Ni─NiN3 dual‐atom structures from coal. Benefiting from the modulated electronic structure that optimizes intermediate adsorption, Ni‐DACs outperform Ni‐SACs in CO2 electroreduction, achieving a max FECO of 98.6% at −0.8 V vs RHE and a TOF ...
Jiabao Niu, Hongqiang Li, Yong Li, Dedong Jia, Neng Chen, Hongmei Li, Min Liu, Jieshan Qiu, Xiaojun He   +8 more
wiley   +1 more source

Biomass‐Coupled HER System: A Strategy for Sustainable and Low‐Cost Hydrogen Production

Carbon Energy, EarlyView.
Pine wood is carbonized into a hierarchically porous biochar anode that undergoes carbon oxidation reaction, replacing the oxygen evolution reaction in alkaline water electrolysis. The resulting biomass‐coupled HER system converts water into hydrogen at low cell voltages, enabling low‐cost H2 production from renewable carbon resources. ABSTRACT Biomass‐
Yuming Huang, Wei Zhou, Liang Xie, Miaoting Sun, Junfeng Li, Xuewei Zhang, Jiaxiang Chen, Xiaoxiao Meng, Jihui Gao, Guangbo Zhao, Bo Song   +10 more
wiley   +1 more source

Thin-layer chromatography of corticosteroids

Journal of Pharmacy and Pharmacology, 1964
openaire   +2 more sources

Electrochemical Design of Atomically Conformal Ga2O3 Buffer Layers via Cu2O‐Catalyzed Nitrate Reduction Reaction for Efficient Cu2O Photocathodes

Carbon Energy, EarlyView.
Cu2O catalyzes nitrate reduction to locally generate OH− at the electrode surface, enabling the first uniform electrochemical deposition of Ga2O3. The Cu2O/Ga2O3‐based photocathodes achieve onset potentials above 1 VRHE, 3.8% solar‐to‐hydrogen efficiency, and stable operation for over 60 h in all‐inorganic tandem PEC devices.
Ji Hoon Choi, Hak Hyeon Lee, Ji Hye Jeong, Dong Su Kim, Kun Woong Lee, Won Seok Yang, Hyung Koun Cho   +6 more
wiley   +1 more source