Results 141 to 150 of about 1,228,239 (309)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Pengaruh Gaya Belajar dan Sikap Siswa pada Pelajaran Matematika terhadap Kemampuan Berpikir Kritis Matematika [PDF]

, 2014
The general objective of this research is to find and analyze empirically about the critical thinking skills of students towards mathematics courses in terms of students' learning styles and attitudes.
KARIM, A. (ABDUL)
core  

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Analyzing the Relationship between Perceived Educational Ethics and Thinking Styles of Students with Academic Enthusiasm: The Mediating Role of Academic Engagement [PDF]

International Journal of Ethics and Society
Introduction: Academic enthusiasm is one of the concepts of positive psychology in educational processes, which can increase under the influence of perceived educational ethics, thinking style and academic engagement. The present study was conducted with
Hala Adnan Kazem Al-Adi, Hassan Ghalavandi, Behnaz Mohajeran   +2 more
doaj  

Kreativitas Pengajuan Soal Ditinjau dari Gaya Kognitif Materi Bangun Segi Empat Kelas VII SMP [PDF]

, 2016
This research aimed to describe the students creativity of problem posing in terms of cognitive style on quadrangles material in seventh garde of SMP. It research used descriptive method.
Hamdani, H. (Hamdani), Jamiah, Y. (Yulis), Marsela, M. (Marsela)   +2 more
core  

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Investigating Ideals of Professional Ethics in Islamic banking [PDF]

International Journal of Ethics and Society
Introduction: Islamic banking is a type of banking or banking activity that is consistent with the rules of Islam and naturally emphasizes moral issues. The purpose of this study is to examine the ideals of professional ethics in Islamic banking in Iran.
Babak Kalantari, Sanjar Salajeghe, Ayyub Sheykhi   +2 more
doaj  

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Psychotype and Thinking Style as Predictors of Success in Esports

Physical Education Theory and Methodology
Objectives. This study aimed to identify the cluster structure of esports athletes’ psychological profiles based on psychotype, thinking style, age, and gaming experience, with the objective of applying the findings to training programs and psychological
Oksana Shynkaruk, Serhii Hrishkin, Nataliia Byshevets, Andrii Skalozub, Ivan Lut, Valerii Pinchuk   +5 more
doaj   +1 more source