Results 61 to 70 of about 62,355 (256)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
PENGARUH GAYA BERPIKIR, INTEGRITAS DAN USIA PADA PERILAKU KERJA YANG KONTRAPRODUKTIF
Jurnal Psikologi Ulayat: Indonesian Journal of Indigenous Psychology, 2012 This study explores the effects of thinking style, integrity and age on counterproductive work behavior (CWB). Using between subject design for 122 workers in young adulthood and 68 workers in middle adulthood, the study utilizes rational experiential ...
Mira Permatasari
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Forum: Qualitative Social Research, 2003 Computer and worldview is not an ethnology of computer culture as a whole, even though the description on the dustcover promises this. Instead, it consists of four more or less separate parts, each not uninteresting on its own.
Till Westermayer
doaj
Kesalahan Konsep dan Prosedur Siswa dalam Menyelesaikan Soal Persamaan Ditinjau dari Gaya Berpikir
Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan, 2018 : The purpose of this qualitative descriptive research is describing the errors of concepts and procedures by four different thinking styles students in solving equations problem.
Muhammad Sa’duddien Khair +2 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
PENGARUH PENGGUNAAN METODE GUIDED INQUIRY DAN GAYA BERPIKIR TERHADAP HASIL BELAJAR KOGNITIF KELAS V
Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan, 2017 The research aims to determine the effect of use of guided inquiry method and thinking stlye on cognitive learning outcomes of classroom at 5th grade elementary school. The design of this research used a quasi-experimental design factorial 2x2.
Heri Susanto +2 more
doaj +1 more source