Results 11 to 20 of about 68,955 (108)
The Multifaceted Role of Epoxide Hydrolases in Human Health and Disease
International Journal of Molecular Sciences, 2020 Epoxide hydrolases (EHs) are key enzymes involved in the detoxification of xenobiotics and biotransformation of endogenous epoxides. They catalyze the hydrolysis of highly reactive epoxides to less reactive diols.
Jérémie Gautheron, I. Jéru
semanticscholar +1 more source
Comparative biochemistry of four polyester (PET) hydrolases
bioRxiv, 2020 The potential of bioprocessing in a circular plastic economy has strongly stimulated research in enzymatic degradation of different synthetic resins. Particular interest has been devoted to the commonly used polyester, poly(ethylene terephthalate) (PET),
J. A. Bååth +4 more
semanticscholar +1 more source
Stem Cells International, Volume 2019, Issue 1, 2019., 2019 Adipose‐derived mesenchymal stem cells (MSC‐ATs) are representative cell sources for cell therapy. However, how cell stress resulting from passage influences the MSC‐AT protein expression has been unclear. In this study, a protein expression analysis was performed by liquid chromatography with tandem mass spectrometry (LC‐MS/MS) using mouse primary ...
Yoshiki Nakashima +9 more
wiley +1 more source
Frontiers in Microbiology, 2019 The cell wall (CW) of bacteria is an intricate arrangement of macromolecules, at least constituted of peptidoglycan (PG) but also of (lipo)teichoic acids, various polysaccharides, polyglutamate and/or proteins. During bacterial growth and division, there
A. Vermassen +5 more
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Microbial Polyethylene Terephthalate Hydrolases: Current and Future Perspectives
Frontiers in Microbiology, 2020 Plastic has rapidly transformed our world, with many aspects of human life now relying on a variety of plastic materials. Biological plastic degradation, which employs microorganisms and their degradative enzymes, has emerged as one way to address the ...
Clodagh M. Carr, D. Clarke, A. Dobson
semanticscholar +1 more source
The Role of the Selective Adaptor p62 and Ubiquitin‐Like Proteins in Autophagy
BioMed Research International, Volume 2014, Issue 1, 2014., 2014 The ubiquitin‐proteasome system and autophagy were long viewed as independent, parallel degradation systems with no point of intersection. By now we know that these degradation pathways share certain substrates and regulatory molecules and show coordinated and compensatory function.
Mónika Lippai +2 more
wiley +1 more source
The BRCA1 ubiquitin ligase and homologous recombination repair
FEBS Letters, Volume 585, Issue 18, Page 2836-2844, September 16, 2011., 2011 Impairment of homologous recombination (HR), a vital process employed during repair of DNA double strand breaks and stalled DNA replication, provides a valuable opportunity for the cell to become transformed. Once transformed, the impairment turns to be a target for therapy as exemplified by the synthetic lethal strategy such as poly (ADP‐ribose ...
Tomohiko Ohta, Ko Sato, Wenwen Wu
wiley +1 more source
PLoS Pathogens, 2019 Research on bile acids has increased dramatically due to recent studies demonstrating their ability to significantly impact the host, microbiome, and various disease states [1–3].
M. H. Foley +3 more
semanticscholar +1 more source
Strategies for Tuning the Selectivity of Chemical Probes that Target Serine Hydrolases.
Cell Chemical Biology, 2020 Serine hydrolases comprise a large family of enzymes that have diverse roles in key cellular processes, such as lipid metabolism, cell signaling, and regulation of post-translation modifications of proteins. They are also therapeutic targets for multiple
Franco F. Faucher +3 more
semanticscholar +1 more source
Gut, 2019 Objective Faecal microbiota transplant (FMT) effectively treats recurrent Clostridioides difficile infection (rCDI), but its mechanisms of action remain poorly defined. Certain bile acids affect C. difficile germination or vegetative growth.
B. Mullish +15 more
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