Results 21 to 30 of about 68,955 (108)

Konvergenter Aufbau Homo‐ und Heterotypischer Ubiquitinketten aus funktionaliserten, exprimierten Monomeren mittels Thiol‐En‐Chemie

Angewandte Chemie, Volume 137, Issue 21, May 19, 2025.
Die Erzeugung funktionalisierter Ubiquitinbausteine mittels Expression in E. coli bietet Zugang zu verschiedenen Di‐, Tri‐ und Tetra‐Ubiquitinketten. Photoinitiierte Thiol‐En‐Klickreaktionen werden dabei in Kombination mit einer Maskierungs‐ und Schutzgruppenstrategie zum kontrollierten Aufbau von Ubiquitinketten sowie zur Semisynthese von ...
Moritz Urschbach, Susanne Huhmann, Dominik Appel, Luca Ferrari, Dominik Vogl, Sascha Martens, Christian F. W. Becker   +6 more
wiley   +1 more source

Development of a Covalent Inhibitor of Gut Bacterial Bile Salt Hydrolases

bioRxiv, 2019
Bile salt hydrolase (BSH) enzymes are widely expressed by human gut bacteria and catalyze the gateway reaction leading to secondary bile acid formation. Bile acids regulate key metabolic and immune processes by binding to host receptors.
Arijit A. Adhikari, T. Seegar, S. Ficarro, S. Ficarro, Megan D. McCurry, Deepti Ramachandran, Lina Yao, S. N. Chaudhari, Sula Ndousse-Fetter, Alexander S. Banks, J. Marto, J. Marto, S. Blacklow, A. Devlin   +13 more
semanticscholar   +1 more source

Identification and Experimental Validation of Biomarkers Associated With Mitochondria and Macrophage Polarization in Sepsis

Emergency Medicine International, Volume 2025, Issue 1, 2025.
Background: Sepsis is a common and serious condition, where mitochondria and macrophage polarization play a crucial role. Therefore, this study aimed to identify and validate biomarkers for sepsis associated with mitochondria‐related genes (MCRGs) and macrophage polarization–related genes (MPRGs), providing new targets and strategies for therapeutic ...
Liping She, Xiaojing Deng, Yeping Bian, Hui Cheng, Jian Xu, Roberto Cirocchi   +5 more
wiley   +1 more source

Whole genome methylation sequencing in blood reveals differential DNA methylation in pathways associated with mitochondrial function in persons with late‐onset dementia due to Alzheimer’s disease (AD)

Alzheimer's &Dementia, Volume 20, Issue S1, December 2024.
Abstract Background DNA microarray‐based studies report differentially methylated positions (DMPs) in blood between cognitively unimpaired persons (CU) and persons with late‐onset dementia due to Alzheimer’s disease (AD) or Mild Cognitive Impairment (MCI) but interrogate less than 4% of the human genome.
Alexander E Boruch, Isabelle Renteria, Andy Madrid, Coleman E Breen, Ligia A Papale, Lindsay R. Clark, Phillip E Bergmann, Sanjay Asthana, Sterling C. Johnson, Sündüz Keles, Dane B. Cook, Kirk J. Hogan, Reid S Alisch   +12 more
wiley   +1 more source

Reductive Release from a Hybrid PKS‐NRPS during the Biosynthesis of Pyrichalasin H

Chemistry – A European Journal, Volume 30, Issue 4, January 16, 2024.
The reductive release of cytochalasin intermediates was studied in vitro, showing that the R‐domain requires a T‐domain tethered substrate, but has low selectivity for the amino acid and polyketide moieties. Direct 2‐electron reduction is the preferred mode of release, followed by rapid Knoevenagel cyclisation of the released aldehyde.
Henrike Heinemann, Haili Zhang, Russell J. Cox   +2 more
wiley   +1 more source

Degradation of Polyester Polyurethane by Bacterial Polyester Hydrolases

Polymers, 2017
Polyurethanes (PU) are widely used synthetic polymers. The growing amount of PU used industrially has resulted in a worldwide increase of plastic wastes.
Juliane Schmidt, Ren Wei, Thorsten Oeser, L. A. Dedavid e Silva, Daniel Breite, Agnes Schulze, W. Zimmermann   +6 more
semanticscholar   +1 more source

Discovering novel hydrolases from hot environments.

Biotechnology Advances, 2018
Novel hydrolases from hot and other extreme environments showing appropriate performance and/or novel functionalities and new approaches for their systematic screening are of great interest for developing new processes, for improving safety, health and ...
Roland Wohlgemuth, J. Littlechild, D. Monti, K. Schnorr, Teunke van Rossum, B. Siebers, P. Menzel, I. Kublanov, A. Rike, Georgios Skretas, Zalán Szabó, Xu Peng, M. Young   +12 more
semanticscholar   +1 more source

Glycoside Hydrolases across Environmental Microbial Communities

PLoS Comput. Biol., 2016
Across many environments microbial glycoside hydrolases support the enzymatic processing of carbohydrates, a critical function in many ecosystems. Little is known about how the microbial composition of a community and the potential for carbohydrate ...
Renaud Berlemont, A. Martiny
semanticscholar   +1 more source

AIG1 and ADTRP are Atypical Integral Membrane Hydrolases that Degrade Bioactive FAHFAs

Nature Chemical Biology, 2016
Enzyme classes may contain outlier members that share mechanistic, but not sequence or structural relatedness with more common representatives. The functional annotation of such exceptional proteins can be challenging.
W. Parsons, Matthew J. Kolar, Siddhesh S. Kamat, A. Cognetta, Jonathan J. Hulce, E. Saez, B. Kahn, A. Saghatelian, B. Cravatt   +8 more
semanticscholar   +1 more source

Exopolysaccharide biosynthetic glycoside hydrolases can be utilized to disrupt and prevent Pseudomonas aeruginosa biofilms

Science Advances, 2015
Therapeutic enzyme treatment disrupts Pseudomonas biofilms, potentiating antibiotics and ameliorating the innate immune system. Bacterial biofilms present a significant medical challenge because they are recalcitrant to current therapeutic regimes. A key
Perrin Baker, P. Hill, Brendan D. Snarr, Brendan D. Snarr, Noor Alnabelseya, Matthew J. Pestrak, Mark J. Lee, Mark J. Lee, Laura K. Jennings, J. Tam, R. Melnyk, M. Parsek, Donald C. Sheppard, Donald C. Sheppard, D. Wozniak, P. Howell   +15 more
semanticscholar   +1 more source