Results 91 to 100 of about 182,890 (341)

Nucleophilic Addition of Thiols to Deoxynivalenol [PDF]

, 2015
Conjugation of deoxynivalenol (DON) with sulfur compounds is recognized as a significant reaction pathway, and putative DON–glutathione (DON–GSH) conjugates have been reported in planta.
Alistair L. Wilkins, Wilkins, Alistair Lawrence, Solhaug, Anita, Ana Stanic (1364481), Frode Rise, Alistair L. Wilkins (1288317), Silvio Uhlig, Frode Rise (292380), Miles, Christopher Owen, Ana Stanic, Stanic, Ana, Christopher O. Miles, Rise, Frode, Uhlig, Silvio, Silvio Uhlig (1364487), Anita Solhaug, Wilkins, Alistair L., Anita Solhaug (1364490), Miles, Christopher O., Christopher O. Miles (1364484)   +19 more
core   +1 more source

Tumor‐Targeted Hyaluronic Acid/Tannic Acid‐Engineered Oxygen Nanogenerators With IR780 Payloads Enable Dual‐Mode Glutathione Depletion and Effective Singlet Oxygen Generation for Melanoma Treatment

Advanced Healthcare Materials, EarlyView.
A hyaluronic acid/tannic acid‐engineered Prussian blue oxygen nanogenerator loaded with IR780 is developed to enhance melanoma phototherapy. By integrating tumor targeting, oxygen self‐supply, and dual‐mode glutathione depletion, the nanoplatform effectively overcomes hypoxia and antioxidant defenses, potentiating synergistic photothermal/photodynamic ...
Chai‐How Hsu, I‐Ju Liu, Hsiang‐Yun Chih, Tsai‐Ching Hsu, Ju‐An Liang, Chia‐Wei Kuo, Bor‐Show Tzang, Wen‐Hsuan Chiang   +7 more
wiley   +1 more source

Clinical efficiency of exogenous L-arginine in patients with essential hypertension against the background of chronic obstructive pulmonary disease

Patologìâ, 2019
Chronic obstructive pulmonary disease (COPD) and essential hypertension (EH) are one of the most common, leading and current problems of practical public health.
O. V. Kraidashenko, O. S. Tiahla
doaj   +1 more source

Quantification of Phosphorylated Tau Protein in Alzheimer's Disease Patients’ Fluids With Electrolyte‐Gated Organic Transistor Biosensors

Advanced Healthcare Materials, EarlyView.
Dementia syndrome affects millions of people in the world, and Alzheimer's disease (AD) is the most common cause. We report the detection of the specific biomarker for AD, p‐tau‐181, from physiological to pathological concentrations in cerebrospinal fluid using an electrolyte‐gated organic transistor biosensor.
Marcello Berto, Pamela A. Manco Urbina, Alessandro Paradisi, Matteo Sensi, Najara Iacovino, Chiara Carbone, Roberta Bedin, Marcello Pinti, Fabio Biscarini, Giovanna Zamboni, Carlo A. Bortolotti   +10 more
wiley   +1 more source

From Cell‐Derived Vesicles to Hybrid Nanovectors: Biological Membranes as Functional Blueprints for Gene Delivery

Advanced Healthcare Materials, EarlyView.
Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari, Claudia Leone, Gabriella Leccese, Claudia De Stradis, Alessandra Invidia, Concetta Quintarelli, Biagio De Angelis, Franco Locatelli, Giuseppe Gigli, Gabriele Maiorano, Ilaria Elena Palamà   +10 more
wiley   +1 more source

Silica Sulfuric Acid Promotes Aza-Michael Addition Reactions under Solvent-Free Condition as a Heterogeneous and Reusable Catalyst

Molecules, 2009
A highly efficient, inexpensive, recyclable, convenient, and green protocol for chemoselective aza-Michael addition reactions of amines/thiols to α,β-unsaturated compounds using silica sulfuric acid (SSA or SiO2-SO3H) was developed. This method is simple,
Sheng-Rong Guo, Yan-Qin Yuan, Yan Wang
doaj   +1 more source

Interactions of Peroxynitrite, Tetrahydrobiopterin, Ascorbic Acid, and Thiols

Journal of Biological Chemistry, 2003
Tetrahydrobiopterin (BH4) serves as a critical co-factor for the endothelial nitric-oxide synthase (eNOS). A deficiency of BH4 results in eNOS uncoupling, which is associated with increased superoxide and decreased NO• production.
Nermin Kuzkaya, N. Weissmann, D. Harrison, S. Dikalov   +3 more
semanticscholar   +1 more source

2‐Deoxyglucose Dendrimer‐Enabled Niclosamide Delivery to FRβ‐Expressing Macrophages Alleviates Endometriosis Progression and Associated Hyperalgesia

Advanced Healthcare Materials, EarlyView.
A folic acid (FA)‐conjugated 2‐deoxyglucose dendrimer selectively targets FRβ+ macrophages in endometriotic lesions, enabling precise intracellular delivery of niclosamide. This nonhormonal nanomedicine enhances drug solubility, provides controlled intracellular release, suppresses lesion growth, reduces inflammation and pain, and establishes FRβ ...
Anubhav Dhull, Mingxin Shi, Madeleine E. Harvey, Taylor M. Page, Rishi Sharma, Kenneth John Goody, Aqib Iqbal Dar, Nash S. Moawad, Vijay Kumar Sirohi, Paul S. Cooke, Kanako Hayashi, Anjali Sharma   +11 more
wiley   +1 more source

Electrochemical Dehydrogenative Phosphorylation of Thiols

, 2023
We report herein a new approach for the synthesis of organothiophosphates from phosphonates and thiols through electrochemical reaction. The reactions were conducted without the addition of oxidant, transition-metal base, or base at room temperature ...
Yi-Xuan Li, You-Chen Liu, Daggula Mallikarjuna Reddy, Chung-Yen Li, Chin-Fa Lee   +4 more
core  

Thiols and disulfides in the tumor microenvironment: characterization of quiescin sulfhydryl oxidase 1 (QSOX1) in the extracellular matrix

, 2022
Gleghorn, Jason P.Pancreatic ductal adenocarcinoma (PDAC) is the 4th leading cause of cancer-related deaths in the U.S., despite only being the 11th most common cancer.
Millar-Haskell, Catherine S
core   +1 more source