PACSIN2 as a modulator of autophagy and mercaptopurine cytotoxicity: mechanisms in lymphoid and intestinal cells. [PDF]
Life Sci Alliance, 2023 PACSIN2 variants are associated with gastrointestinal effects of thiopurines and thiopurine methyltransferase activity through an uncharacterized mechanism that is postulated to involve auto-phagy.
Zudeh G +10 more
europepmc +3 more sources
Impact of mercaptopurine metabolites on disease outcome in the AIEOP-BFM 2009 protocol for acute lymphoblastic leukemia [PDF]
, 2023 : In the maintenance phase of AIEOP-BFM acute lymphoblastic leukemia (ALL) 2009 protocol, mercaptopurine (MP) is given at the planned dose of 50 mg/m2/day; however, dose adjustments are routinely performed to target patients' white blood cells to the ...
Bertorello, Nicoletta +16 more
core +1 more source
Pharmacokinetics and pharmacodynamics of thiopurines in an in\ua0vitro model of human hepatocytes: Insights from an innovative mass spectrometry assay [PDF]
, 2017 AIM: To apply an innovative LC-MS/MS method to quantify thiopurine metabolites in human hepatocytes and to associate them to cytotoxicity. METHODS: Immortalized human hepatocytes (IHH cells) were treated for 48 and 96 h, with 1.4 7 10-4 M azathioprine ...
Decorti, Giuliana +12 more
core +1 more source
Photo-Active Biological Molecular Materials: From Photoinduced Dynamics to Transient Electronic Spectroscopies [PDF]
, 2021 We present an overview of a methodology for the simulation of the photo-response of biological (macro)molecules, designed around a Quantum Mechanics / Molecular Mechanics (QM/MM) subtractive scheme.
A Anda +201 more
core +1 more source
Extent of metal ion-sulfur binding in complexes of thiouracil nucleosides and nucleotides in aqueous solution [PDF]
, 2007 医薬保健研究域 薬学系Previously published stability constants of several metal ion (M2+) complexes formed with thiouridines and their 5′-monophosphates, together with recently obtained log KM (U)M versus p KUH plots for M2+ complexes of uridinate derivatives (U ...
小谷 明
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American Gastroenterological Association Institute Technical Review on the Role of Therapeutic Drug Monitoring in the Management of Inflammatory Bowel Diseases [PDF]
, 2017 Therapeutic drug monitoring (TDM), which involves measurement of drug or active metabolite levels and anti-drug antibodies, is a promising strategy that can be used to optimize inflammatory bowel disease therapeutics.
Falck-Ytter, Yngve +4 more
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Use of divalent metal ions in the DNA cleavage reaction of topoisomerase IV [PDF]
, 2011 It has long been known that type II topoisomerases require divalent metal ions in order to cleave DNA. Kinetic, mutagenesis and structural studies indicate that the eukaryotic enzymes utilize a novel variant of the canonical two-metal-ion mechanism to ...
A. B. Burgin +40 more
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Human topoisomerase IIα uses a two-metal-ion mechanism for DNA cleavage [PDF]
, 2008 The DNA cleavage reaction of human topoisomerase IIα is critical to all of the physiological and pharmacological functions of the protein. While it has long been known that the type II enzyme requires a divalent metal ion in order to cleave DNA, the role
A. B. Burgin +35 more
core +2 more sources
Metabolic reconstruction of sulfur assimilation in the extremophile Acidithiobacillus ferrooxidans based on genome analysis [PDF]
, 2003 BACKGROUND: Acidithiobacillus ferrooxidans is a gamma-proteobacterium that lives at pH2 and obtains energy by the oxidation of sulfur and iron. It is used in the biomining industry for the recovery of metals and is one of the causative agents of acid ...
A Bateman +63 more
core +2 more sources
The Enzymes of Biotin Dependent CO(2) Metabolism: What Structures Reveal about Their Reaction Mechanisms [PDF]
, 2012 Biotin is the major cofactor involved in carbon dioxide metabolism. Indeed, biotin-dependent enzymes are ubiquitous in nature and are involved in a myriad of metabolic processes including fatty acid synthesis and gluconeogenesis. The cofactor, itself, is
Holden, Hazel M +2 more
core +2 more sources