PACSIN2 as a modulator of autophagy and mercaptopurine cytotoxicity: mechanisms in lymphoid and intestinal cells [PDF]
, 2023 PACSIN2 variants are associated with gastrointestinal effects of thiopurines and thiopurine methyltransferase activity through an uncharacterized mechanism that is postulated to involve auto-phagy.
Bonten, Erik J +10 more
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Pharmacokinetics and pharmacodynamics of thiopurines in an in\ua0vitro model of human hepatocytes: Insights from an innovative mass spectrometry assay [PDF]
, 2017 AIM: To apply an innovative LC-MS/MS method to quantify thiopurine metabolites in human hepatocytes and to associate them to cytotoxicity. METHODS: Immortalized human hepatocytes (IHH cells) were treated for 48 and 96 h, with 1.4 7 10-4 M azathioprine ...
Decorti, Giuliana +12 more
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Photo-Active Biological Molecular Materials: From Photoinduced Dynamics to Transient Electronic Spectroscopies [PDF]
, 2021 We present an overview of a methodology for the simulation of the photo-response of biological (macro)molecules, designed around a Quantum Mechanics / Molecular Mechanics (QM/MM) subtractive scheme.
A Anda +201 more
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Extent of metal ion-sulfur binding in complexes of thiouracil nucleosides and nucleotides in aqueous solution [PDF]
, 2007 医薬保健研究域 薬学系Previously published stability constants of several metal ion (M2+) complexes formed with thiouridines and their 5′-monophosphates, together with recently obtained log KM (U)M versus p KUH plots for M2+ complexes of uridinate derivatives (U ...
小谷 明
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Artificial Specific Binders Directly Recovered from Chemically Modified Nucleic Acid Libraries
Journal of Nucleic Acids, Volume 2012, Issue 1, 2012., 2012 Specific binders comprised of nucleic acids, that is, RNA/DNA aptamers, are attractive functional biopolymers owing to their potential broad application in medicine, food hygiene, environmental analysis, and biological research. Despite the large number of reports on selection of natural DNA/RNA aptamers, there are not many examples of direct screening
Yuuya Kasahara +2 more
wiley +1 more source
American Gastroenterological Association Institute Technical Review on the Role of Therapeutic Drug Monitoring in the Management of Inflammatory Bowel Diseases [PDF]
, 2017 Therapeutic drug monitoring (TDM), which involves measurement of drug or active metabolite levels and anti-drug antibodies, is a promising strategy that can be used to optimize inflammatory bowel disease therapeutics.
Falck-Ytter, Yngve +4 more
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The Enzymes of Biotin Dependent CO(2) Metabolism: What Structures Reveal about Their Reaction Mechanisms [PDF]
, 2012 Biotin is the major cofactor involved in carbon dioxide metabolism. Indeed, biotin-dependent enzymes are ubiquitous in nature and are involved in a myriad of metabolic processes including fatty acid synthesis and gluconeogenesis. The cofactor, itself, is
Holden, Hazel M +2 more
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Inhibition of Yeast Hexokinase by the Antimalarial Drug Artemisinin: Probing Mechanism of Action with a Model Enzyme [PDF]
, 2009 A leading infectious cause of death, malaria threatens approximately half of the world\u27s population, and drug-resistant strains of Plasmodium falciparum have created immense difficulty in chemotherapy of the disease.
Spence, Jennifer S.
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Studies Towards Nucleic Acids at the Origins of Life [PDF]
, 2021 Nucleic acids are at the heart of extant biology and the structure of life’s original genetic polymer is still a question of debate. The RNA world theory proposes that RNA was the first nucleic acid employed as life’s genetic polymer due to its dual ...
Colville, Ben W.F.
core
Hybrid modelling of biological systems using fuzzy continuous Petri nets [PDF]
, 2019 Copyright © The Author(s) 2019. Integrated modelling of biological systems is challenged by composing components with sufficient kinetic data and components with insufficient kinetic data or components built only using experts’ experience and knowledge ...
Gilbert, D, Heiner, M, Liu, F, Sun, W
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