Results 211 to 220 of about 7,079 (242)

The Clinical Impact of Thiopurine Methyltransferase Polymorphisms on Thiopurine Treatment

Nucleosides, Nucleotides and Nucleic Acids, 2004
Acute lymphoblastic leukaemia (ALL) is the most common malignancy of childhood. Although current treatment results in long term survival in over 70% of cases there is evidence that as many as 50% could have been cured using a less complex regimen with a lower incidence of long term side effects.
S A, Coulthard, E C, Matheson, A G, Hall, L A, Hogarth   +3 more
openaire   +2 more sources

Purine substrates for human thiopurine methyltransferase

Biochemical Pharmacology, 1994
Thiopurine methyltransferase (TPMT) catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG). A genetic polymorphism regulating TPMT activity in human tissue is an important factor responsible for individual differences in the toxicity and therapeutic efficacy of these drugs.
M, Deininger, C L, Szumlanski, D M, Otterness, J, Van Loon, W, Ferber, R M, Weinshilboum   +5 more
openaire   +2 more sources

Pharmacogenetics of Thiopurine S-Methyltransferase and Thiopurine Therapy

Therapeutic Drug Monitoring, 2004
Most medications exhibit wide interpatient variability in their efficacy and toxicity. For many medications, these interindividual differences result in part from polymorphisms in genes encoding drug-metabolizing enzymes, drug transporters, and/or drug targets (eg, receptors, enzymes).
openaire   +2 more sources

Interethnic difference in thiopurine methyltransferase activity

Clinical Pharmacology and Therapeutics, 1992
A number of metabolic pathways are subject to both genetic polymorphism and interethnic differences. A catabolic pathway of 6-mercaptopurine, red blood cell (RBC) thiopurine methyltransferase (TPMT) activity showed genetic polymorphism in Caucasians, but variation according to ethnicity has not been studied. We investigated if red blood cell thiopurine
B, Klemetsdal, E, Tollefsen, T, Loennechen, K, Johnsen, E, Utsi, K, Gisholt, E, Wist, J, Aarbakke   +7 more
openaire   +2 more sources

Individualization of Thiopurine Therapy: Thiopurine S -Methyltransferase and Beyond

Pharmacogenomics, 2009
The metabolism of a given drug depends, not solely on a particular enzyme, but rather on a complex metabolic network. Thiopurine S-methyltransferase (TPMT) catalyzes the methylation, and thus deactivation, of 6-mercaptopurine, a thiopurine used in the treatment of acute lymphoblastic leukemia.
Natasa, Karas-Kuzelicki, Irena, Mlinaric-Rascan   +1 more
openaire   +2 more sources

Clinical Pharmacogenomics of Thiopurine S-methyltransferase

Current Clinical Pharmacology, 2006
Thiopurine methyltransferase (TPMT) catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (6-MP), thioguanine and azathioprine (AZA). These drugs are used to treat conditions such as acute lymphoblastic leukemia, inflammatory bowel disease, rheumatoid arthritis, and organ transplant rejection. This review highlights the polymorphisms
Zhou, Shufeng, Brink
openaire   +3 more sources

The Effect of Thiopurine Methyltransferase Expression on Sensitivity to Thiopurine Drugs

Molecular Pharmacology, 2002
Although the thiopurine drugs 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG) are well established agents for the treatment of leukemia, controversies remain regarding their main mode of action. Previous evidence has suggested that although 6-TG exerts a cytotoxic effect through incorporation of 6-thioguanine nucleotides into newly synthesized DNA ...
Coulthard, S.A., Hogarth, L.A., Little, M.A., Matheson, E., Redfern, C.P.F., Minto, C.L.J., Hall, A.G.   +13 more
openaire   +3 more sources

METHYLATION PHARMACOGENETICS: Catechol O-Methyltransferase, Thiopurine Methyltransferase, and Histamine N-Methyltransferase

Annual Review of Pharmacology and Toxicology, 1999
▪ Abstract  Methyl conjugation is an important pathway in the biotransformation of many exogenous and endogenous compounds. Pharmacogenetic studies of methyltransferase enzymes have resulted in the identification and characterization of functionally important common genetic polymorphisms for catechol O-methyltransferase, thiopurine methyltransferase ...
R M, Weinshilboum, D M, Otterness, C L, Szumlanski   +2 more
openaire   +2 more sources

Human thiopurine methyltransferase pharmacogenetics: Gene sequence polymorphisms*

Clinical Pharmacology & Therapeutics, 1997
Thiopurine methyltransferase (TPMT) catalyzes the S-methylation of thiopurine drugs. TPMT activity is regulated by a common genetic polymorphism that is associated with large individual variations in thiopurine toxicity and efficacy. We previously cloned the functional gene for human TPMT and reported a common variant allele for low enzyme activity ...
D, Otterness, C, Szumlanski, L, Lennard, B, Klemetsdal, J, Aarbakke, J O, Park-Hah, H, Iven, K, Schmiegelow, E, Branum, J, O'Brien, R, Weinshilboum   +10 more
openaire   +2 more sources

Clinical Utility of Thiopurine S-Methyltransferase Genotyping

American Journal of PharmacoGenomics, 2004
Thiopurine S-methyltransferase (TPMT) is a cytosolic enzyme that plays a major role in the metabolism of thiopurine drugs such as mercaptopurine and azathioprine. The interindividual differences in response to thiopurine administration is in part due to the presence of genetic polymorphisms in the gene that regulates TPMT activity.
Hèctor, Corominas, Montserrat, Baiget
openaire   +2 more sources