Results 221 to 230 of about 6,964 (243)

Interethnic difference in thiopurine methyltransferase activity

Clinical Pharmacology and Therapeutics, 1992
A number of metabolic pathways are subject to both genetic polymorphism and interethnic differences. A catabolic pathway of 6-mercaptopurine, red blood cell (RBC) thiopurine methyltransferase (TPMT) activity showed genetic polymorphism in Caucasians, but variation according to ethnicity has not been studied. We investigated if red blood cell thiopurine
B, Klemetsdal, E, Tollefsen, T, Loennechen, K, Johnsen, E, Utsi, K, Gisholt, E, Wist, J, Aarbakke   +7 more
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Clinical Utility of Thiopurine S-Methyltransferase Genotyping

American Journal of PharmacoGenomics, 2004
Thiopurine S-methyltransferase (TPMT) is a cytosolic enzyme that plays a major role in the metabolism of thiopurine drugs such as mercaptopurine and azathioprine. The interindividual differences in response to thiopurine administration is in part due to the presence of genetic polymorphisms in the gene that regulates TPMT activity.
Hèctor, Corominas, Montserrat, Baiget
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Pharmacogenomics: Catechol O-Methyltransferase to Thiopurine S-Methyltransferase

Cellular and Molecular Neurobiology, 2006
1. Pharmacogenomics is the study of the role of inheritance in variation in the drug response phenotype-a phenotype that can vary from adverse drug reactions at one end of the spectrum to lack of therapeutic efficacy at the other. 2. The thiopurine S-methyltransferase (TPMT) genetic polymorphism represents one of the best characterized and most ...
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Thiopurine methyltransferase polymorphisms in a Brazilian population

The Pharmacogenomics Journal, 2003
Thiopurine methyltransferase (TPMT) catalyses the S-methylation of thiopurine drugs. Low-activity phenotypes are correlated with several mutations in the TPMT gene. Polymorphisms of TPMT have been reported for Caucasians, African-Americans and Asians. Since ethnic differences have been demonstrated worldwide, it remains to be elucidated in Brazil.
W L, Boson, M A, Romano-Silva, H, Correa, R P, Falcão, P V, Teixeira-Vidigal, L, De Marco   +5 more
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Glutathione: An endogenous substrate for thiopurine methyltransferase?

Biochemical and Biophysical Research Communications, 1985
An investigation was initiated to determine if glutathione is an endogenous substrate for thiopurine methyltransferase. Glutathione, as well as S-methylglutathione, were each capable of inhibiting the enzyme in a concentration-dependent manner, which suggested competitive and product inhibition, respectively.
G, Loo, J T, Smith
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Getting the Best Out of Thiopurine Therapy: Thiopurine S -Methyltransferase and Beyond

Biomarkers in Medicine, 2015
Thiopurines are the cornerstone of treatment for a wide variety of medical disorders, ranging from pediatric leukemia to inflammatory bowel disease. Because of their complex metabolism and potential toxicities, the use of biomarkers to predict risk and response is paramount.
Steven Chung Ming, Fong, Paul Andrew, Blaker, Monica, Arenas-Hernandez, Anthony Marin, Marinaki, Jeremy David, Sanderson   +4 more
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Assessment of Thiopurine S-Methyltransferase Activity in Patients Prescribed Thiopurines: A Systematic Review

Annals of Internal Medicine, 2011
The evidence for testing thiopurine S-methyltransferase (TPMT) enzymatic activity or genotype before starting therapy with thiopurine-based drugs is unclear.To examine the sensitivity and specificity of TPMT genotyping for TPMT enzymatic activity, reducing harm from thiopurine by pretesting, and the association of thiopurine toxicity with TPMT status ...
Booth, Ronald A, Ansari, Mohammed T, Loit, Evelin, Tricco, Andrea C, Weeks, Laura, Doucette, Steve, Skidmore, Becky, Sears, Margaret, Sy, Richmond, Karsh, Jacob   +9 more
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Role of Thiopurine Metabolite Testing and Thiopurine Methyltransferase Determination in Pediatric IBD

Journal of Pediatric Gastroenterology and Nutrition, 2013
ABSTRACTThiopurines have been used in inflammatory bowel disease (IBD) for >30 years, and measurements of both thiopurine methyltransferase (TPMT) and thiopurine (TP) metabolites, 6‐thioguanine nucleotides (6‐TGN) and 6‐methylmercaptopurine (6‐MMP), have been readily available.
Keith, Benkov, Ying, Lu, Ashish, Patel, Riad, Rahhal, Gary, Russell, Jonathan, Teitelbaum   +5 more
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No Induction of Thiopurine Methyltransferase During Thiopurine Treatment in Inflammatory Bowel Disease

Nucleosides, Nucleotides and Nucleic Acids, 2006
The aim of this study was to follow, during standardized initiation of thiopurine treatment, thiopurine methyltransferase (TPMT) gene expression and enzyme activity and thiopurine metabolite concentrations, and to study the role of TPMT and ITPA 94C > A polymorphisms for the development of adverse drug reactions.
M, Lindqvist, U, Hindorf, S, Almer, P, Söderkvist, M, Ström, H, Hjortswang, C, Peterson   +6 more
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Synthesis of Modified Thiopurine Nucleosides for Structural Characterization of Human Thiopurine S-Methyltransferase

Nucleosides and Nucleotides, 1999
Synthesis of a number of photoactive thiopurine-containing nucleosides was described. S-methylation of the synthesized compounds in the course of the reaction catalyzed by recombinant human thiopurine S-methyltransferase was studied by UV-spectroscopy.
G A, Korshunova, E Y, Krynetski, M T, Mtchedlidze, D V, Agapkin, W E, Evans, N F, Krynetskaia   +5 more
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