Results 221 to 230 of about 7,079 (242)

Pharmacogenomics: Catechol O-Methyltransferase to Thiopurine S-Methyltransferase

Cellular and Molecular Neurobiology, 2006
1. Pharmacogenomics is the study of the role of inheritance in variation in the drug response phenotype-a phenotype that can vary from adverse drug reactions at one end of the spectrum to lack of therapeutic efficacy at the other. 2. The thiopurine S-methyltransferase (TPMT) genetic polymorphism represents one of the best characterized and most ...
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Thiopurine methyltransferase biochemical genetics: Human lymphocyte activity

Biochemical Genetics, 1982
The level of human erythrocyte (RBC) thiopurine methyltransferase (TPMT) activity is inherited as a monogenic trait. Experiments were performed to determine whether the level of TPMT activity in the human lymphocyte is regulated in parallel with RBC TPMT. Supernatants of lymphocyte homogenates contained TPMT activity.
J A, Van Loon, R M, Weinshilboum
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Differential effects of mesalazine formulations on thiopurine metabolism through thiopurine S‐methyltransferase inhibition

Journal of Gastroenterology and Hepatology, 2021
AbstractBackground and AimThiopurines are often used in combination with mesalazine for the treatment of ulcerative colitis (UC). Mesalazine formulations are delivered to the digestive tract by various delivery systems and absorbed as 5‐aminosalicylic acid (5‐ASA).
Hiromu Morikubo, Taku Kobayashi, Ryo Ozaki, Shinji Okabayashi, Satoshi Kuronuma, Osamu Takeuchi, Tenyo Shiba, Hiroki Kiyohara, Mao Matsubayashi, Shintaro Sagami, Masaru Nakano, Osamu Ikezaki, Tadakazu Hisamatsu, Yoichi Tanaka, Toshifumi Hibi   +14 more
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Thiopurine methyltransferase polymorphisms in a Brazilian population

The Pharmacogenomics Journal, 2003
Thiopurine methyltransferase (TPMT) catalyses the S-methylation of thiopurine drugs. Low-activity phenotypes are correlated with several mutations in the TPMT gene. Polymorphisms of TPMT have been reported for Caucasians, African-Americans and Asians. Since ethnic differences have been demonstrated worldwide, it remains to be elucidated in Brazil.
W L, Boson, M A, Romano-Silva, H, Correa, R P, Falcão, P V, Teixeira-Vidigal, L, De Marco   +5 more
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Glutathione: An endogenous substrate for thiopurine methyltransferase?

Biochemical and Biophysical Research Communications, 1985
An investigation was initiated to determine if glutathione is an endogenous substrate for thiopurine methyltransferase. Glutathione, as well as S-methylglutathione, were each capable of inhibiting the enzyme in a concentration-dependent manner, which suggested competitive and product inhibition, respectively.
G, Loo, J T, Smith
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Thiopurine S-methyltransferase pharmacogenetics

Pharmacogenetics, 2003
Thiopurine S-methyltransferase (TPMT) catalyses the S-methylation of thiopurine drugs such as 6-mercaptopurine. A common genetic polymorphism for TPMT is associated with large individual variations in thiopurine drug toxicity and therapeutic efficacy.
Liewei, Wang, William, Sullivan, David, Toft, Richard, Weinshilboum   +3 more
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Role of Thiopurine Metabolite Testing and Thiopurine Methyltransferase Determination in Pediatric IBD

Journal of Pediatric Gastroenterology and Nutrition, 2013
ABSTRACTThiopurines have been used in inflammatory bowel disease (IBD) for >30 years, and measurements of both thiopurine methyltransferase (TPMT) and thiopurine (TP) metabolites, 6‐thioguanine nucleotides (6‐TGN) and 6‐methylmercaptopurine (6‐MMP), have been readily available.
Keith, Benkov, Ying, Lu, Ashish, Patel, Riad, Rahhal, Gary, Russell, Jonathan, Teitelbaum   +5 more
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No Induction of Thiopurine Methyltransferase During Thiopurine Treatment in Inflammatory Bowel Disease

Nucleosides, Nucleotides and Nucleic Acids, 2006
The aim of this study was to follow, during standardized initiation of thiopurine treatment, thiopurine methyltransferase (TPMT) gene expression and enzyme activity and thiopurine metabolite concentrations, and to study the role of TPMT and ITPA 94C > A polymorphisms for the development of adverse drug reactions.
M, Lindqvist, U, Hindorf, S, Almer, P, Söderkvist, M, Ström, H, Hjortswang, C, Peterson   +6 more
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Mouse thiopurine methyltransferase pharmacogenetics: monogenic inheritance.

The Journal of Pharmacology and Experimental Therapeutics, 1987
Thiopurine methyltransferase (TPMT) catalyzes the S-methylation of aromatic and heterocyclic sulfhydryl compounds such as the drug 6-mercaptopurine. In humans, TPMT activity is inherited as a monogenic trait. It would be useful if there were an animal model in which the genetic regulation of TPMT could be studied.
D M, Otterness, R M, Weinshilboum
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Thiopurine Methyltransferase and Thiopurine Metabolite Testing in Patients with Inflammatory Bowel Disease who are Taking Thiopurine Drugs

Pharmacogenomics, 2009
Thiopurine methyltransferase genotyping and thiopurine metabolite testing has been established as an adjunct to monitoring patients taking thiopurine drugs. This special report describes the clinical implications for this type of testing for patients with inflammatory bowel disease who are taking thiopurine drugs.
Leslie J, Sheffield, Peter, Irving, Arun, Gupta, Keith, Byron, Finlay A, Macrae, Hazel, Phillimore, Mithilesh, Dronavalli, Rosemary, Rose, Peter, George, Trevor, Walmsley, Barbara, Dixon, Susan, Poole, Michael, Dooley, Miles, Sparrow   +13 more
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