Results 61 to 70 of about 6,964 (243)

Influence of genetic variants in TPMT and COMT associated with cisplatin induced hearing loss in patients with cancer: two new cohorts and a meta-analysis reveal significant heterogeneity between cohorts. [PDF]

PLoS ONE, 2014
Treatment with cisplatin-containing chemotherapy regimens causes hearing loss in 40-60% of cancer patients. It has been suggested that genetic variants in the genes encoding thiopurine S-methyltransferase (TPMT) and catechol O-methyltransferase (COMT ...
Melanie M Hagleitner, Marieke J H Coenen, Ana Patino-Garcia, Eveline S J M de Bont, Anna Gonzalez-Neira, Hanneke I Vos, Frank N van Leeuwen, Hans Gelderblom, Peter M Hoogerbrugge, Henk-Jan Guchelaar, Maroeska W M Te Loo   +10 more
doaj   +1 more source

بررسی شيوع آلل‌های شناخته‌شده ژن آنزيم تيوپورين متيل تراسفراز (TPMT) در مراجعه کنندگان به درمانگاه بيمارستان شريعتی تهران [PDF]

, 2009
زمينه: بيماران با سطوح پائين و يا متوسط فعاليت آنزيم تيوپورين متيل تراسفراز (TPMT) در معرض افزايش خطر ابتلا به سرکوب سلول‎های رده خون ساز مغز استخوان پس از مصرف داروهای تيويورينی خواهند بود.
آزادی, مهدی, حاجی فتحعلی, عباس, سلیمانی, مسعود, نوروزی نیا, مهرداد, کاویانی, سعید   +4 more
core  

Direct evidence of singlet molecular oxygen [O2 (1Δg)] production from UVA excited 6‐thioguanine

Photochemistry and Photobiology, EarlyView.
6‐Thioguanine (6‐TGua) is incorporated into DNA as a purine analogue, inhibiting cell replication. Patients treated with 6‐TGua are more prone to developing skin cancer due to the photoexcitation of 6‐TGua by UVA radiation (as illustrated in the Jablonski diagram). Upon exposure to UVA, the excited 6‐TGua generates 1O2.
André L. Lopes, Fernanda M. Prado, Helena C. Junqueira, Marisa H. G. Medeiros, Graziella E Ronsein, Jean Cadet, Paolo Di Mascio   +6 more
wiley   +1 more source

Successful pregnancies with thiopurine-allopurinol co-therapy for inflammatory bowel disease [PDF]

, 2015
Background: Thiopurines are an effective treatment for moderate to severe inflammatory bowel disease [IBD] and can be used safely in pregnancy. Combining allopurinol with a lower dose of thiopurine can improve clinical efficacy and bypass some adverse ...
Ansari, Azhar, Duley, John, Florin, Timothy, Nelson-Piercy, Catherine, Sheikh, Mohammed   +4 more
core   +1 more source

The first live term birth following uterus transplantation in Australia

Medical Journal of Australia, Volume 223, Issue 8, Page 404-409, October 2025.
Abstract Objective To report the first live birth following uterus transplantation in Australia. Study design Case report. Setting, participant The first participant in the uterus transplantation research study program at the Royal Hospital for Women, the Prince of Wales Hospital, and Westmead Hospital in Sydney.
Rebecca Deans, Brigitte Gerstl, Antonia W Shand, Sarah Lyons, Aaron Budden, Helen L Barrett, Grant Luxton, Mangalee Fernando, Kenneth Yong, Karen Keung, Kaushalya Arulpragasam, Henry Pleass, King Man Wan, Eva Kehag, Jana‐Emily Pittman, Mianna Lotz, Maria Fenn, Erin Nesbitt‐Hawes, Lily Byun, Katrina Tang, Mats Brannstrom, Jason Abbott   +21 more
wiley   +1 more source

Thiopurines in the Management of Crohn’s Disease: Safety and Efficacy Profile in Patients with Normal TPMT Activity—A Retrospective Study

Canadian Journal of Gastroenterology and Hepatology, 2016
Background and Aims. Thiopurines are used in the treatment of Crohn’s disease (CD) and thiopurine S-methyltransferase (TPMT) activity can guide thiopurine dosing to avoid adverse events.
Amine Benmassaoud, Xuanqian Xie, Motaz AlYafi, Yves Theoret, Alain Bitton, Waqqas Afif, Talat Bessissow   +6 more
doaj   +1 more source

Polymorphisms of the thiopurine S-methyltransferase gene among the Libyan population [PDF]

Libyan Journal of Medicine, 2015
Background: Thiopurine S-methyltransferase (TPMT) is a cytosolic enzyme that catalyses the S-methylation of 6-mercaptopurine and azathioprine. Low activity phenotypes are correlated with polymorphism in the TPMT gene.
Hamza Ben Zeglam, Abdrazak Benhamer, Adel Aboud, Haitem Rtemi, Meftah Mattardi, Saleh Suleiman Saleh, Abdullah Bashein, Nabil Enattah   +7 more
doaj   +1 more source

Azathioprine-Induced Peripheral T Cell Apoptosis And Drug Response In Patients With Crohn’s Disease [PDF]

, 2011
Background and Aim: the long time interval for a trial of thioupurine therapy and the potential side effects in spite of the proven efficacy, do not encourage their use as early therapeutic option in Crohn’s Disease (CD).
Cossu, Andrea
core  

Dual Malignancies in IgG4‐Related Disease: A Diagnostic and Therapeutic Challenge

ACR Open Rheumatology, Volume 7, Issue 10, October 2025.
We report a rare case of IgG4‐related disease (IgG4‐RD) presenting with retroperitoneal fibrosis and autoimmune pancreatitis, followed by sequential development of papillary thyroid carcinoma and diffuse large B cell lymphoma. Histopathologic and positron emission tomography–computed tomography findings were essential for diagnosis and guided timely ...
Ji Li, Ming Zhang, Juanjuan Song, Lina Zhang, Sheng‐Guang Li   +4 more
wiley   +1 more source

Toxicity of azathioprine: why and when? analysis of the prevalence of polymorphism in Joinville, SC, Brazil

Arquivos de Gastroenterologia, 2012
CONTEXT: The use of thiopurine drugs such as azathioprine and 6-mercaptopurine has become quite common in the treatment of inflammatory bowel disease, transplantation and acute leukemias.
Gabriela Roncone Gastal, Simone Moreira, Caroline Furtado Noble, Leslie Ecker Ferreira, Paulo Henrique Condeixa de França, Mauro Pinho   +5 more
doaj   +1 more source