Results 121 to 130 of about 1,394 (176)

Modulation of endogenous opioid signaling by inhibitors of puromycin-sensitive aminopeptidase. [PDF]

Eur J Med Chem
Singh R, Jiang R, Williams J, Dobariya P, Hanak F, Xie J, Rothwell PE, Vince R, More SS.   +8 more
europepmc   +1 more source

Beta-amyloid influences the content and trafficking of beta-amyloid precursor protein via Na,K-ATPase-Src kinase positive feedback loop. [PDF]

Front Pharmacol
Petrushanko IY, Lisitskii DR, Filonov FA, Leonova OG, Mitkevich VA, Strelkova MA, Makarov AA.   +6 more
europepmc   +1 more source

Optimization of Sequential Enzymatic Hydrolysis in Porcine Blood and the Influence on Peptide Profile and Bioactivity of Prepared Hydrolysates. [PDF]

Int J Mol Sci
Moreno-Mariscal C, Moroni F, Pérez-Sánchez J, Mora L, Toldrá F.   +4 more
europepmc   +1 more source

Impact of the diverse cardiotonic steroids on beta-amyloid precursor protein level. [PDF]

Front Pharmacol
Petrushanko IY, Lisitskii DR, Strelkova MA, Tolstova AP, Fedulov AP, Filonov FA, Mitkevich VA, Makarov AA.   +7 more
europepmc   +1 more source

Combating New Delhi metallo-beta-lactamase-1 (NDM-1): an integrated review of inhibitor development and next-generation therapeutic platforms. [PDF]

RSC Adv
Mohanty A, Sahoo RK, Sanket AS, Rout E.
europepmc   +1 more source

Harder than Metal: Challenging Antimicrobial Resistance with Metallo-β-lactamase Inhibitors. [PDF]

J Med Chem
De Falco A, Alfano AI, Cutarella L, Mori M, Brindisi M.   +4 more
europepmc   +1 more source

Study of thiorphan degradation

International Journal of Pharmaceutics, 1988
Abstract The degradation of the enkephalinase inhibitor thiorphan was studied. Liquid chromatography UV and electrochemical detections and several techniques of spectrometry showed that the degradation was oxidative and generates diastereoisomers of the corresponding disulfide.
E Postaire, P Prognon, F Giménez
exaly   +2 more sources

Structures of soluble rabbit neprilysin complexed with phosphoramidon or thiorphan [PDF]

Acta Crystallographica Section F, Structural Biology Communications, 2019
Neutral endopeptidase (neprilysin; NEP) is a proteinase that cleaves a wide variety of peptides and has been implicated in Alzheimer's disease, cardiovascular conditions, arthritis and other inflammatory diseases. The structure of the soluble extracellular domain (residues 55–750) of rabbit neprilysin was solved both in its native form at 2.1 Å ...
Jurgen Sygusch, Pawel Grochulski
exaly   +3 more sources

Thiorphan and retro-thiorphan display equivalent interactions when bound to crystalline thermolysin

Biochemistry, 1989
The three-dimensional structures of (S)-thiorphan and (R)-retro-thiorphan bound to thermolysin have been determined crystallographically and refined to residuals of 0.183 and 0.187 at 1.7-A resolution. Thiorphan [N-[(S)-2-(mercaptomethyl)-1-oxo-3-phenylpropyl]glycine] [HSCH2CH(CH2C6H5)CONHC-H2COOH] and retro-thiorphan [[[(R)-1-(mercaptomethyl)-2 ...
S L, Roderick, M C, Fournie-Zaluski, B P, Roques, B W, Matthews   +3 more
openaire   +3 more sources