Results 111 to 120 of about 1,034 (134)
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Brain Research, 1986
The endogenous opioid peptide enkephalin (EK) is known to be degraded mainly by two enzymes, the dipeptidyl carboxypeptidase 'enkephalinase' and aminopeptidase. Microinjection of the enkephalinase inhibitor thiorphan or the aminopeptidase inhibitor bestatin into the nucleus accumbens of the rabbit produced a dose-dependent analgesic effect.
W Q, Jin, Z F, Zhou, J S, Han
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The endogenous opioid peptide enkephalin (EK) is known to be degraded mainly by two enzymes, the dipeptidyl carboxypeptidase 'enkephalinase' and aminopeptidase. Microinjection of the enkephalinase inhibitor thiorphan or the aminopeptidase inhibitor bestatin into the nucleus accumbens of the rabbit produced a dose-dependent analgesic effect.
W Q, Jin, Z F, Zhou, J S, Han
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Substance P-induced effects in guinea pig lungs: effects of thiorphan and captopril
Journal of Applied Physiology, 1989The effects of the neutral metalloendopeptidase inhibitor, thiorphan, and the angiotensin-converting enzyme inhibitor, captopril, on the changes in airway opening pressure (PaO), pulmonary arterial pressure (Ppa), and weight induced by intravascular administration of substance P were examined in isolated perfused and ventilated guinea pig lungs ...
J M, Drazen, S A, Shore, N P, Gerard
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Neurochemistry International, 1988
Neurotensin induced significant antinociceptive activity as measured in a variety of nociceptive tests 10 and 30 min following intracerebroventricular (i.c.v.) injection in mice. The lowest effective peptide doses were 25 ng in the writhing test, 25-50 ng in the tail-flick test, 50-100 ng in the hot-plate test and 2000 ng in the tail electrical ...
A, Coquerel +3 more
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Neurotensin induced significant antinociceptive activity as measured in a variety of nociceptive tests 10 and 30 min following intracerebroventricular (i.c.v.) injection in mice. The lowest effective peptide doses were 25 ng in the writhing test, 25-50 ng in the tail-flick test, 50-100 ng in the hot-plate test and 2000 ng in the tail electrical ...
A, Coquerel +3 more
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European Neuropsychopharmacology, 1994
A continuous 8-day s.c. administration of morphine (450 microgram/kg/h) sensitized rats to the morphine-induced stimulation of locomotion (morphine test dose = 3 mg/kg, s.c.) but not to the acetorphan (5 mg/kg, i.v.)-induced stimulation of locomotion. On the other hand, a continuous 10-day intracerebroventricular infusion of the enkephalinase inhibitor,
R, Khallouk-Bousselmame, J, Costentin
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A continuous 8-day s.c. administration of morphine (450 microgram/kg/h) sensitized rats to the morphine-induced stimulation of locomotion (morphine test dose = 3 mg/kg, s.c.) but not to the acetorphan (5 mg/kg, i.v.)-induced stimulation of locomotion. On the other hand, a continuous 10-day intracerebroventricular infusion of the enkephalinase inhibitor,
R, Khallouk-Bousselmame, J, Costentin
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Journal of Cardiovascular Pharmacology, 1989
To evaluate the role of endopeptidase 24.11 in metabolism of atrial natriuretic peptide (ANP) in vivo, we examined the effect of thiorphan, an inhibitor of this enzyme, on plasma ANP concentrations and the cardiovascular and renal actions of ANP(99-126).
A J, Trapani +6 more
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To evaluate the role of endopeptidase 24.11 in metabolism of atrial natriuretic peptide (ANP) in vivo, we examined the effect of thiorphan, an inhibitor of this enzyme, on plasma ANP concentrations and the cardiovascular and renal actions of ANP(99-126).
A J, Trapani +6 more
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Journal of Biochemistry, 2001
The effects of the metalloproteinase inhibitors thiorphan and R-94138 on the matrilysin-catalyzed hydrolysis of (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N(3)-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl]-L-Ala-L-Arg-NH(2) [MOCAc-PLGL(Dpa)AR] were examined.
H, Oneda, K, Inouye
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The effects of the metalloproteinase inhibitors thiorphan and R-94138 on the matrilysin-catalyzed hydrolysis of (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N(3)-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl]-L-Ala-L-Arg-NH(2) [MOCAc-PLGL(Dpa)AR] were examined.
H, Oneda, K, Inouye
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Brain Research, 1983
The effects of various i.v. doses of morphine (0.1, 0.3 and 1 mg/kg) and of thiorphan, an inhibitor of enkephalinase (0.7, 2.5, 5, 10 and 15 mg/kg), were studied upon the vocalization threshold to foot pressure in normal rats and rats with Freund's adjuvant-induced arthritis.
V, Kayser, G, Guilbaud
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The effects of various i.v. doses of morphine (0.1, 0.3 and 1 mg/kg) and of thiorphan, an inhibitor of enkephalinase (0.7, 2.5, 5, 10 and 15 mg/kg), were studied upon the vocalization threshold to foot pressure in normal rats and rats with Freund's adjuvant-induced arthritis.
V, Kayser, G, Guilbaud
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Disposition of thiorphan in DOCA-salt and spontaneously hypertensive rats.
Research communications in chemical pathology and pharmacology, 1993Thiorphan was administered intravenously (i.v.) at 10 mg/kg to conscious rats in two different models of hypertension to allow a comparison of pharmacokinetics. The two models were: 1) Deoxycorticosterone acetate (DOCA)-salt uninephrectomized rats; 2) Spontaneously hypertensive rats (SHR), and their respective normotensive controls; 3) Sprague-Dawley ...
Y, Sakane +4 more
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Effects of thiorphan, bestatin and captopril on the Lewis lung carcinoma metastases in mice.
Polish journal of pharmacology, 1996Previously we have found that administration of thiorphan alone or in combination with bestatin exerts antitumor effect in mice, including reduction of B16 melanoma tumor growth and prolongation of survival time. These data prompted us to extend our studies to estimate the effect of treatment with thiorphan, captopril and bestatin on lung metastases in
J, Kowalski +3 more
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Effects of inhaled or intravenous thiorphan on substance P-induced airway obstruction.
Agents and actions. Supplements, 1992Male Hartley guinea pigs were treated with the enkephalinase inhibitor thiorphan by inhaled or intravenous administration routes and potentiation of substance P-induced airway obstruction examined. Inhaled thiorphan was several thousand times more potent than intravenous thiorphan.
S A, Silbaugh +2 more
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