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Chiral Thioureas—Preparation and Significance in Asymmetric Synthesis and Medicinal Chemistry
Molecules, 2020 For almost 20 years, thioureas have been experiencing a renaissance of interest with the emerged development of asymmetric organocatalysts. Due to their relatively high acidity and strong hydrogen bond donor capability, they differ significantly from ...
Dominika Iwan +2 more
exaly +4 more sources
Unclicking of thioureas: Base catalyzed elimination of anilines and isothiocyanates from thioureas [PDF]
Tetrahedron, 2019 Bisaromatic thioureas are widely used in e.g. asymmetric organocatalysis and considered to be robust compounds. Herein we show, in strong contrast to common notion, that thioureas dissociate to amines and isothiocyanates in a base catalyzed reaction under mild conditions. This 'unclicking' process can occur in the presence of weak organic bases even at
Matea Vlatkovic, Ben Feringa
exaly +3 more sources
Mechanochemical synthesis of thioureas, ureas and guanidines
Beilstein Journal of Organic Chemistry, 2017 In this review, the recent progress in the synthesis of ureas, thioureas and guanidines by solid-state mechanochemical ball milling is highlighted. While the literature is abundant on their preparation in conventional solution environment, it was not ...
Vjekoslav Štrukil
doaj +2 more sources
Exploring the latest trends in chemistry, structure, coordination, and diverse applications of 1-acyl-3-substituted thioureas: a comprehensive review [PDF]
RSC AdvAcyl thioureas represent a privileged moiety with vast potential applicability across diverse fields, making them the subject of extensive research efforts. The inherent flexibility of thiourea facilitates the synthesis of a wide range of core structures
Sayyed Aqib Ullah +4 more
semanticscholar +2 more sources
Molecules, 2017 Thiourea derivatives demonstrate potent cytotoxic activity against various leukemias and many tumor cell lines. In our previous study, the combination of thiourea and phosphonate has been proven as an effective strategy for developing antitumor agents ...
Jingzi Liu +7 more
doaj +2 more sources
Water-Soluble Inclusion Complexation of Naphthyl-Containing Thiosemicarbazides and Thioureas with β-Cyclodextrin [PDF]
MoleculesThe paper presents the synthesis of new naphthyl-containing derivatives of thiosemicarbazide and thiourea, their water-soluble inclusion complexes with β-cyclodextrin, as well as an assessment of their potential antiviral and hemorheological activity. As
Oralgazy A. Nurkenov +9 more
doaj +2 more sources
Beilstein Journal of Organic Chemistry, 2016 The catalytic activity of different supported bifunctional thioureas on sulfonylpolystyrene resins has been studied in the nitro-Michael addition of different nucleophiles to trans-β-nitrostyrene derivatives.
José M. Andrés +4 more
doaj +2 more sources
Thiourea-Based H2S-Releasing Pramipexole Hybrids as Neuroprotective Agents [PDF]
AntioxidantsMultitarget hybrid molecules are a promising strategy for treating complex neurodegenerative disorders such as Parkinson’s disease (PD), where dopaminergic dysfunction, oxidative stress, neuroinflammation, and cellular senescence coexist and drive ...
Angela Corvino +12 more
doaj +2 more sources
RSC Advances, 2022 The interest in acyl thioureas has continually been escalating owing to their extensive applications in diverse fields, such as synthetic precursors of new heterocycles, pharmacological and materials science, and technology.
Urage Zahra +4 more
semanticscholar +1 more source
Acta Crystallographica Section E: Crystallographic Communications, 2022 The synthesis and single-crystal X-ray structures of three N,N,N′-trisubstituted thioureas are reported, namely N,N,N′-tribenzylthiourea, C22H22N2S (1), N-methyl-N,N′-diphenylthiourea, C14H14N2S (2), and N,N-di-n-butyl-N′-phenylthiourea, C15H24N2S (3 ...
Evert Dhaene +3 more
doaj +1 more source