Results 81 to 90 of about 2,048,231 (235)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Cancer related PTSD symptoms in patients of all ages and their relatives, and general risk factors [PDF]

, 2017
Since the DSM-IV, a life threatening disease is considered as a potential source of PTSD. One of the core elements of the diagnosis is experiencing a traumatic event or being a witness of a close person experiencing it.
Paleczna, Monika
core   +3 more sources

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Effects of Avatar Perspective on Joint Excursions Used to Play Virtual Dodgeball: Within-Subject Comparative Study

JMIR Serious Games, 2020
BackgroundVisual representation of oneself is likely to affect movement patterns. Prior work in virtual dodgeball showed greater excursion of the ankles, knees, hips, spine, and shoulder occurs when presented in the first-person perspective compared to ...
van der Veen, Susanne M, Stamenkovic, Alexander, Applegate, Megan E, Leitkam, Samuel T, France, Christopher R, Thomas, James S   +5 more
doaj   +1 more source

Making our ends meet: shared intention, goal adoption and the third-person perspective [PDF]

Mind reading (i.e. the ability to infer the mental state of another agent) is taken to be the main cognitive ability required to share an intention and to collaborate. In this paper, I argue that another cognitive ability is also necessary to collaborate:
Tummolini, Luca
core   +1 more source

A motion capture study to measure the feeling of synchrony in romantic couples and in professional musicians [PDF]

, 2016
The feeling of synchrony is fundamental for most social activities and prosocial behaviors. However, little is known about the behavioral correlates of this feeling and its modulation by intergroup differences.
Caecilia Charbonnier, Delphine Preissmann, Francois Ansermet, Jean-Philippe Antonietti, Joan Llobera, Pierre J. Magistretti, Sylvain Chagué   +6 more
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Drift and ownership towards a distant virtual body

Frontiers in Human Neuroscience, 2013
In body ownership illusions participants feel that a mannequin or virtual body (VB) is their own. Earlier results suggest that body ownership over a body seen from behind in extra-personal space is possible when the surrogate body is visually stroked and
Ausias ePomes, Mel eSlater
doaj   +1 more source

True and intentionally fabricated memories [PDF]

, 2012
The aim of the experiment reported here was to investigate the processes underlying the construction of truthful and deliberately fabricated memories.
Addis D.R., Bower G.H., Cabeza R., Colwell K., Conway M.A., Conway M.A., Conway M.A., Conway M.A., D'Argembeau A., Freud S., Granhag P.A., Granhag P.A., Hassabis D., Hassabis D., Johnson M.K., Justice L.V., Kosslyn S.M., Libby L.K., Merckelbach H., Nigro G., Pennebaker J.W., Polage D.C., Porter S., Porter S., Porter S., Reiser B.J., Schacter D.L., Schacter D.L., Szpunar K.K., Trafimow D., Tulving E., Tulving E., Vrij A., Yuille J.C.   +33 more
core   +1 more source