Results 101 to 110 of about 7,387,250 (229)
Proceedings. First Assembly of the Latin-America and Caribbean Seismological Commission - LACSC
Earth Sciences Research Journal, 2014 The Latin-American and Caribbean region is an area with a very complex tectonic setting, where stress and strain generated by the interaction of several lithospheric plates is being absorbed.
Third Latin-American Congress of Seismol Third Latin-American Congress of Seismology
doaj
Bridging trust gaps: Stakeholder perspectives on AI adoption in the United Kingdom NHS primary care
Digital HealthObjectives This study investigates the factors influencing artificial intelligence (AI) acceptance in the United Kingdom (UK) National Health Services (NHS) primary care across different stakeholder levels. It explores key barriers and enablers, focusing
Teresa Sides +3 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
, 2022 This is volume 12 of an 18‐volume collection of early Cincinnati baptismal, marriage, and funeral records that predate city records. These materials are heavily used by genealogy researchers and scholars.
Third German Protestant Church
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Third Street School, Los Angeles, 1989
, 1989 Third Street School, untitled mural, 1989, Third Street School, exterior eating area, 201 South June Street (between 2nd and 3rd Sts.), Hancock Park. The school as it might have looked during pre-historic times (students riding a dinosaur and the school ...
Dunitz, Robin J. +2 more
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Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source