Results 71 to 80 of about 246,372 (310)

Physiologically based pharmacokinetic model combined with a clinical lactation study to determine doravirine concentrations in human breastmilk

British Journal of Clinical Pharmacology, EarlyView.
Aims To determine breastmilk concentrations of doravirine via PBPK modelling in combination with a clinical lactation study. As women living with HIV are not able to cease antiretroviral therapy during lactation, it is necessary to establish drug transfer into breastmilk to determine exposure of the infant to antiretroviral drugs and potential risk of ...
Lena van der Wekken‐Pas, David Burger, Rick Greupink, Angela Colbers   +3 more
wiley   +1 more source

Malondialdehyde and antioxidant enzymes in second and third trimesters of pre-eclamptic Nigerian women

Nigerian Postgraduate Medical Journal, 2014
Aim and Objective: To determine changes in malondialdehyde (product of lipid peroxidation) and antioxidant enzymes (Superoxide Dismutase, Glutathione Per- oxidase) levels in pre-eclamptic Nigerian women Patients and Methods: A Total of 100 subjects each
A S Atiba, F M Abbiyesuku, D A Adekanle, D P Oparinde, O A Ajose, T A Niran-Atiba   +5 more
doaj  

Population pharmacokinetic modelling of amoxicillin in human breast milk—A contribution from the ConcePTION project

British Journal of Clinical Pharmacology, EarlyView.
Aims Amoxicillin, a widely used β‐lactam antibiotic, requires improved pharmacokinetic characterization during breastfeeding. This study used a population pharmacokinetic (PopPK) approach to model amoxicillin concentrations in breast milk, identify variability sources and estimate infant exposure, applying worst‐case scenarios.
Sarah Baklouti, Virginie Rigourd, Alice Panchaud, Hedvig Nordeng, Karel Allegaert, Pieter Annaert, Miao‐Chan Huang, Anaelle Monfort, Monia Guidi, Peggy Gandia   +9 more
wiley   +1 more source

Hubungan Karakteristik Ibu Hamil Trimester III dengan Kecemasan dalam Menghadapi Persalinan di Poliklinik Kebidanan dan Kandungan Rumah Sakit X Jakarta [PDF]

, 2010
Pregnancy is a dramatic episode of the biological conditions, physiological changes, and adaptation of a woman who've been there. Some women think that pregnancy is natural to go through, but some regard it as a decisive event to the next life.
Team, R. (Redaksi)
core  

Tacrolimus exposure during pregnancy in kidney and liver transplantation recipients: A comparison between whole blood and plasma concentration‐to‐dose ratios

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Tacrolimus monitoring is generally performed in whole blood (WB). Most (>85%) of circulating tacrolimus is bound to red blood cells. During pregnancy, WB monitoring might be suboptimal because of physiological changes including increased plasma volume and decreased haematocrit.
Jildau R. Meinderts, Paola Mian, Frederike G. I. van Vilsteren, Karien M. H. van de Wetering, Jelmer R. Prins, Stefan P. Berger, Daan J. Touw, Margriet F. C. de Jong   +7 more
wiley   +1 more source

Determination of placenta location in third trimester of pregnancy by ultrasonography

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 1999
Objective: Placenta is an important organ for communication of mother and fetus, and the main route of nutritional intake and excretion of fetal waste matter.
S Esmaeil Zadeh
doaj  

Longitudinal hematological change in uncomplicated twin pregnancies: The white blood cell count decreases through pregnancy after the first trimester

Taiwanese Journal of Obstetrics & Gynecology
Objective: Longitudinal hematological changes throughout twin pregnancies have not been reported. This study aimed to reveal longitudinal changes in hematological indices in twin pregnancies.
Masaki Sekiguchi, Jin Muromoto, Kohei Ogawa, Katsusuke Ozawa, Naoyuki Miyasaka, Haruhiko Sago   +5 more
doaj   +1 more source

Zuranolone: A case study in (regulatory) rush to judgement?

British Journal of Clinical Pharmacology, EarlyView.
Abstract Sage, in collaboration with Biogen, submitted a new drug approval for zuranolone for postpartum depression (PPD) and major depressive disorder (MDD) in December 2022. In August 2023, the US Food and Drug Administration granted approval for PPD but denied approval for MDD.
Lisa Cosgrove, Milutin Kostic, Barbara Mintzes, Gianna D'Ambrozio, Allen Shaughnessy   +4 more
wiley   +1 more source

Fetal and infant growth and the risk of obesity during early childhood: the Generation R Study. [PDF]

, 2011
OBJECTIVE: To examine whether infant growth rates are influenced by fetal growth characteristics and are associated with the risks of overweight and obesity in early childhood. DESIGN: This study was embedded in the Generation R Study, a population-based
Durmuş, Büşra, Hofman, Albert, Jaddoe, Vincent WV, Jarvelin, Marjo-Riitta, Mook-Kanamori, Dennis O, Raat, Hein, Sovio, Ulla, Steegers, Eric AP   +7 more
core   +1 more source

Lesions Associated With Autism Symptoms Map to a Cerebellar Brain Network in Tuberous Sclerosis Complex

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Objective Autism spectrum disorder (ASD) affects 1 in 36 individuals in the United States and is characterized by impaired social communication and restrictive/repetitive behaviors. Individuals with tuberous sclerosis complex (TSC) have a high incidence of ASD (40%) and exhibit congenital brain lesions (tubers), offering a unique lesion‐based ...
Wendy Xiao Herman, Gillian N. Miller, Mustafa Sahin, Jurriaan M. Peters, Simon K. Warfield, Darcy A. Krueger, E. Martina Bebin, Hope Northrup, Joyce Y. Wu, Michael D. Fox, Alexander L. Cohen   +10 more
wiley   +1 more source