Results 91 to 100 of about 213,616 (295)
Brazilian Journal of Medical and Biological Research, 2001 We demonstrate here that acute third ventricle injections of GR 113808, a highly selective 5-HT4 antagonist, decrease water intake induced by a previous salt load while potentiating drinking elicited by hypovolemia induced by previous subcutaneous ...
L. Castro +9 more
doaj +1 more source
Advanced Science, EarlyView.An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang +10 more
wiley +1 more source
Advanced Science, EarlyView.Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao +36 more
wiley +1 more source
FastVentricle: Cardiac Segmentation with ENet
, 2017 Cardiac Magnetic Resonance (CMR) imaging is commonly used to assess cardiac structure and function. One disadvantage of CMR is that post-processing of exams is tedious. Without automation, precise assessment of cardiac function via CMR typically requires
A Suinesiaputra +9 more
core +1 more source
Irgm1 Improves Postinfarction Cardiac Repair by Promoting Neutrophil Clearance and Efferocytosis
Advanced Science, EarlyView.The Irgm1‐PDIA3 axis enhances post‐infarction cardiac repair by accelerating neutrophil clearance and facilitating efferocytosis. Irgm1 holds potential as a prognostic biomarker in MI, and LOC14 may represent a therapeutic option to improve cardiac repair, especially in cases of Irgm1 deficiency.
Zeng Wang +14 more
wiley +1 more source
Interdisciplinary Neurosurgery, 2017 Background: Since the origin and growth pattern of third ventricle ectopic pituitary adenoma (ectPA) remain unclear, its optimal surgical approach is debatable. Clinical presentation: We present a rare case of null cell pituitary adenoma arising from the
Yuichiro Yoneoka, M.D., Ph.D. +5 more
doaj +1 more source
The Heart of a Horse: 3‐D Echocardiographic Analysis of the Equine Aortic Valve [PDF]
, 2019 Aortic regurgitation (AR) can be a normal function of aging or a disease in younger horses. Symptoms range from no outward signs to decreased performance to sudden cardiac arrest.
McElhinney, Amber
core +1 more source
3D Bioprinted Fat‐Myocardium Model Unravels the Role of Adipocyte Hypertrophy in Atrial Dysfunction
Advanced Science, EarlyView.A human‐derived 3D bioprinted fat–myocardium model is developed to investigate how adipocyte hypertrophy drives atrial dysfunction in obesity. Palmitate‐induced adipocyte hypertrophy promotes adipose dysfunction that impairs atrial cardiomyocyte metabolism and electrophysiology through both paracrine and direct interactions. This platform recapitulates
Lara Ece Celebi, Pinar Zorlutuna
wiley +1 more source
Respiratory‐Limbic Coupling via a Thalamic Circuit Alleviates Anxiety
Advanced Science, EarlyView.This study delineates a conserved preBötCGlu→PVT→CeA circuit that gates anxiety and respiration. Activation of this circuit is anxiolytic and respiratory‐stabilizing, while its inhibition has the opposite effect. Mechanistically, PVT exerts its anxiolytic action via a disinhibitory microcircuit: its inputs preferentially target CeL GABAergic neurons ...
Shangyu Bi +15 more
wiley +1 more source
Endoscopic third ventriculostomy may have long term efficacy in low birth weight preterm newborns
Brazilian Neurosurgery, 2013 Endoscopic third ventriculostomy (ETV) is an established treatment for hydrocephalus and is an alternative method avoiding shunts and its complications. There is still controversy regarding the higher risk of failure in younger infants.
Matheus Fernandes de Oliveira +2 more
doaj +1 more source