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Bourbon virus, a newly discovered zoonotic thogotovirus
Journal of General Virology, 2023 The recent discovery of Bourbon virus (BRBV) put a new focus on the genus of thogotoviruses as zoonotic, tick-transmitted pathogens within the orthomyxovirus family. Since 2014, BRBV has been linked to several human cases in the Midwest United States with severe acute febrile illness and a history of tick bites.
Elias Bendl, Jonas Fuchs, Georg Kochs
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Virology, 2017 The genome and structural organization of a novel insect-specific orthomyxovirus, designated Sinu virus, is described. Sinu virus (SINUV) was isolated in cultures of C6/36 cells from a pool of mosquitoes collected in northwestern Colombia. The virus has six negative-sense ssRNA segments. Genetic analysis of each segment demonstrated the presence of six
Hilda Guzman +2 more
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Virus Research, 2018 The genus Thogotovirus, as represented by Thogoto virus and Dhori virus, comprises a group of arthropod-borne viruses, most members of which are transmitted by ticks. Here we report the genetic and biological characterization of a new thogotovirus, designated Oz virus (OZV), isolated from the hard tick Amblyomma testudinarium in Ehime, Japan.
Chang-Kweng Lim +2 more
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Improving Baculovirus Transduction of Mammalian Cells by Incorporation of Thogotovirus Glycoproteins [PDF]
Virologica Sinica, 2019 Baculovirus can transduce a wide range of mammalian cells and is considered a promising gene therapy vector. However, the low transduction efficiency of baculovirus into many mammalian cells limits its practical application. Co-expressing heterologous viral glycoproteins (GPs), such as vesicular stomatitis virus G protein (VSV G), with baculovirus ...
Fei Deng, Zhihong Hu, Hualin Wang
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Fulminant Viral Myocarditis Associated with Thogotovirus
New England Journal of MedicineNorihiko Terada +2 more
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Surveillance for Tick-Borne Viruses Near the Location of a Fatal Human Case of Bourbon Virus (Family Orthomyxoviridae: Genus Thogotovirus) in Eastern Kansas, 2015 [PDF]
Journal of Medical Entomology, 2018 Bourbon virus (Family Orthomyxoviridae: Genus Thogotovirus) was first isolated from a human case-patient residing in Bourbon County, Kansas, who subsequently died. Before becoming ill in late spring of 2014, the patient reported several tick bites. In response, we initiated tick surveillance in Bourbon County and adjacent southern Linn County during ...
Harry M Savage +2 more
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Molecular, serological and in vitro culture-based characterization of Bourbon virus, a newly described human pathogen of the genus Thogotovirus [PDF]
Journal of Clinical Virology, 2015 In June of 2014, a previously healthy man from Kansas with a recent history of tick exposure died from complications related to an illness marked by fever, thrombocytopenia and leukopenia. An isolate was derived from the blood of this patient during the course of diagnostic testing.
Amy J Lambert +2 more
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Segment-specific promoter activity for RNA synthesis in the genome of Oz virus, genus Thogotovirus
VirologyAbstract Oz virus (OZV), a tick-borne, six-segmented negative-strand RNA virus in the genus Thogotovirus, caused a fatal human infection in Japan in 2023. To investigate mechanisms of viral RNA synthesis, we developed an OZV minigenome assay used in mammalian cells.
Lipi Akter +2 more
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