Results 111 to 120 of about 763 (127)

Bourbon virus, a newly discovered zoonotic thogotovirus

Journal of General Virology, 2023
The recent discovery of Bourbon virus (BRBV) put a new focus on the genus of thogotoviruses as zoonotic, tick-transmitted pathogens within the orthomyxovirus family. Since 2014, BRBV has been linked to several human cases in the Midwest United States with severe acute febrile illness and a history of tick bites.
Georg Kochs, Jonas Fuchs, Elias Bendl
exaly   +5 more sources

Improving Baculovirus Transduction of Mammalian Cells by Incorporation of Thogotovirus Glycoproteins [PDF]

Virologica Sinica, 2019
Baculovirus can transduce a wide range of mammalian cells and is considered a promising gene therapy vector. However, the low transduction efficiency of baculovirus into many mammalian cells limits its practical application. Co-expressing heterologous viral glycoproteins (GPs), such as vesicular stomatitis virus G protein (VSV G), with baculovirus ...
Manli Wang, Hualin Wang, Zhihong Hu
exaly   +3 more sources

Characterization of a novel thogotovirus isolated from Amblyomma testudinarium ticks in Ehime, Japan: A significant phylogenetic relationship to Bourbon virus

Virus Research, 2018
The genus Thogotovirus, as represented by Thogoto virus and Dhori virus, comprises a group of arthropod-borne viruses, most members of which are transmitted by ticks. Here we report the genetic and biological characterization of a new thogotovirus, designated Oz virus (OZV), isolated from the hard tick Amblyomma testudinarium in Ehime, Japan.
Masayuki Saijo, Chang Kweng Lim, Ryosuke Fujita   +2 more
exaly   +3 more sources

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Fulminant Viral Myocarditis Associated with Thogotovirus

New England Journal of Medicine
Norihiko Terada, Aya Matsuu, Kazunori Kikuchi   +2 more
exaly   +3 more sources

Molecular, serological and in vitro culture-based characterization of Bourbon virus, a newly described human pathogen of the genus Thogotovirus [PDF]

Journal of Clinical Virology, 2015
In June of 2014, a previously healthy man from Kansas with a recent history of tick exposure died from complications related to an illness marked by fever, thrombocytopenia and leukopenia. An isolate was derived from the blood of this patient during the course of diagnostic testing.
Aaron Brault, Lesley Bell-Sakyi, Amy Lambert   +2 more
exaly   +3 more sources

Surveillance for Tick-Borne Viruses Near the Location of a Fatal Human Case of Bourbon Virus (Family Orthomyxoviridae: Genus Thogotovirus) in Eastern Kansas, 2015 [PDF]

Journal of Medical Entomology, 2018
Bourbon virus (Family Orthomyxoviridae: Genus Thogotovirus) was first isolated from a human case-patient residing in Bourbon County, Kansas, who subsequently died. Before becoming ill in late spring of 2014, the patient reported several tick bites. In response, we initiated tick surveillance in Bourbon County and adjacent southern Linn County during ...
Ram Raghavan, Kristen L Burkhalter, Marvin S Godsey   +2 more
exaly   +3 more sources

DHORI VIRUS (ORTHOMYXOVIRIDAE: THOGOTOVIRUS) INFECTION IN MICE: A MODEL OF THE PATHOGENESIS OF SEVERE ORTHOMYXOVIRUS INFECTION

American Journal of Tropical Medicine and Hygiene, 2007
After intranasal, subcutaneous, or intraperitoneal infection with Dhori virus (DHOV), adult mice developed a fulminant and uniformly fatal illness with many of the clinical and pathologic findings seen in mice infected with H5N1 highly pathogenic avian influenza A virus.
Amelia P A Travassos da Rosa
exaly   +3 more sources

Segment-specific promoter activity for RNA synthesis in the genome of Oz virus, genus Thogotovirus

Virology
Abstract Oz virus (OZV), a tick-borne, six-segmented negative-strand RNA virus in the genus Thogotovirus, caused a fatal human infection in Japan in 2023. To investigate mechanisms of viral RNA synthesis, we developed an OZV minigenome assay used in mammalian cells.
Haruhiko Isawa, Lipi Akter, Ryo Matsumura   +2 more
exaly   +3 more sources

Dhori Virus (Orthomyxoviridae: Thogotovirus) Infection of Mice Produces a Disease and Cytokine Response Pattern Similar to That of Highly Virulent Influenza A (H5N1) Virus Infection in Humans

American Journal of Tropical Medicine and Hygiene, 2008
Mice infected with Dhori virus (DHOV) develop a fulminant, systemic, and uniformly fatal illness that has many of the clinical and pathologic findings seen in H5N1 influenza A virus infection. However, the role of host’s immune response in DHOV infection remains unclear. In this study, the concentrations of 23 inflammatory cytokines and chemokines were
Guangyu Li, Elena Sbrana
exaly   +3 more sources