Results 31 to 40 of about 3,940,537 (256)

Structural implications for selective targeting of PARPs

Frontiers in Oncology, 2013
Poly(ADP-ribose) polymerases (PARPs) are a family of enzymes that use NAD+ as a substrate to synthesize polymers of ADP-ribose (PAR) as post-translational modifications of proteins.
Jamin D. Steffen, Jonathan R. Brody, Roger S. Armen, John Matteson Pascal   +3 more
doaj   +1 more source

Chicken Pulmonary MicroRNAs Targeting the PB2 (Segment 1) of Avian Influenza Virus

Animal Research and One Health, EarlyView.
The PB2 segment of H5N1 is essential for replication and host adaptation. We screened 200 miRNAs and identified five (gga‐miR‐17‐3p, gga‐miR‐29a‐5p, gga‐miR‐1718, gga‐miR‐16c‐5p, and gga‐miR‐1744‐5p) using thermodynamic stability of heteroduplex, seed sequence complementarity, conservation, and accessibility, offering insights into host antiviral ...
Akanksha Choudhary, Nidhishree N. S, Rakesh Kumar Pundir, Muhasin Asaf V. N, Anamika Mishra, Ashwin Ashok Raut, Megha Agarwal, Amod Kumar   +7 more
wiley   +1 more source

Reception at new hospital, Thomas Jefferson University, June 9, 1978

, 1978
Dr. Lewis W. Bluemle, President of Thomas Jefferson University, stands with Dr. Thomas Berhrendt at the reception for the opening and dedication of the new hospital (Gibbon Building).https://jdc.jefferson.edu/historical_photos/2076/thumbnail ...

core   +3 more sources

Student Perspectives and Standardized Patient Feedback on an Innovative Simulated Patient Encounter

Journal of Occupational Therapy Education, 2021
This retrospective survey analysis sought to explore student perspectives and application of therapeutic use of self during a simulated standardized patient encounter (SSPE) with standardized patient actors portraying serious mental illness (SMI ...
Kimberly S. Mollo, Tina M. DeAngelis, MacIain Capron, Sierra Wells   +3 more
doaj   +1 more source

Design, printing optimization, and material testing of a 3D-printed nasal osteotomy task trainer

3D Printing in Medicine, 2023
Background For difficult or rare procedures, simulation offers an opportunity to provide education and training. In developing an adequate model to utilize in simulation, 3D printing has emerged as a useful technology to provide detailed, accessible, and
Lauren Schlegel, Eric Malani, Sara Belko, Ayan Kumar, Eric Barbarite, Howard Krein, Ryan Heffelfinger, Morgan Hutchinson, Robert Pugliese   +8 more
doaj   +1 more source

Outcomes in Progressive Pulmonary Fibrosis in Systemic Autoimmune Rheumatic Diseases: Real‐World Data From the ILD‐PRO Registry

Arthritis &Rheumatology, EarlyView.
Objective We evaluated baseline characteristics, treatment patterns, and outcomes in patients with systemic autoimmune rheumatic disease–associated progressive pulmonary fibrosis (SARD‐PPF) and evaluated whether outcomes differed by SARD subtype. Methods The ILD‐PRO Registry is a prospective multicenter US registry of patients with PPF.
Sonali J. Bracken, Jeremy M. Weber, Megan L. Neely, Aparna C. Swaminathan, Scott M. Palmer, Erin M. Wilfong, Ann D. Chauffe, Elizabeth R. Volkmann   +7 more
wiley   +1 more source

A Computer Supported Interprofessional Education Initiative: Using Technology to Advance Interprofessionalism

MedEdPORTAL, 2013
Introduction A long-term strategic goal of Thomas Jefferson University's InterProfessional Education Center (JCIPE) was identified to “create innovative learning environments that support interprofessional education including state-of-the-art ...
Kellie Smith, Reena Antony, Sokha Koeuth, Lauren Collins, Anthony Frisby   +4 more
doaj   +1 more source

MDL‐800‐induced SIRT6 activation decreases age‐associated osteoarthritis in mice

Arthritis &Rheumatology, Accepted Article.
Objective SIRT6 is a nuclear‐localized histone deacetylase that regulates multiple pathways associated with aging. This study aimed to determine whether systemic administration of a small molecule activator of SIRT6, MDL‐800, decreases the severity of age‐associated osteoarthritis (OA) in mice.
Matheus Moreira Perez, Pranay Ramteke, Bahiyah Watson, Owen Haslam, Eirene Choi, Susan Chubinskaya, Mandy J. Peffers, William R. Davis, Jacqueline Shine, Brian O. Diekman, Richard F. Loeser, Theresa A. Freeman, Makarand V. Risbud, John A. Collins   +13 more
wiley   +1 more source

Risk Factors Associated with Pyogenic Spinal Infections among Intravenous Drug Users and Nonusers

Advances in Orthopedics
Background Data. Spinal infections are major clinical problems with a substantial financial burden on healthcare systems. Recent increases in primary pyogenic spine infections can be attributed to the opioid epidemic and an aging and increasingly ...
Vivek K. Bilolikar, Brendan Gleason, Lee Kripke, Robert Merrill, Colin Whitaker, Jon Handal   +5 more
doaj   +1 more source

Prediction of Prevalent Cardiovascular Disease Using Social, Environmental, and Behavioral Factors: A Vital Conditions Framework Approach

Chronic Diseases and Translational Medicine, EarlyView.
The Vital Conditions Framework. Graphical representation of the Vital Conditions for Health Framework with seven domains. Images used with permission from The Rippel Foundation: An Introduction to the Vital Conditions for Health and Well‐Being. https://rippel.org/events/webinar-an-introduction-to-the-vital-conditions-for-health-and-well-being/. Federal
Stephanie Kjelstrom, Richard Hass, Robert Vollbrecht, Brandon George, Sharon Larson   +4 more
wiley   +1 more source