Results 31 to 40 of about 4,317,660 (341)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Julius-Kühn-Archiv, 2020 Bacillus thuringiensis subsp. aizawai, a widely used biological plant protection product, was tested on buff-tailed bumblebee Bombus terrestris, using an updated laboratory method on full standardized R&D colonies.
Sterk, Guido +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Julius-Kühn-Archiv, 2020 Bumblebees (Bombus terrestris) are exposed daily to Plant Protection Products through their foraging and feeding activities. Through all possible means of contact with pesticides, consumption through sugarwater is the most severe.
Sterk, Guido +2 more
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
`The moloch of details'? cycles of criticism and the meaning of history now [PDF]
, 2008 In a recent review of Tim Blanning’s The Pursuit of Glory: Europe, 1648– 1815 (2007), Keith Thomas marvelled at the author’s range, given that ‘the volume of specialised writing has grown immeasurably since the 1950s’ and because ‘the subject matter of ...
MacRaild, Don
core +1 more source
FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source
InsectsDue to its potential as a sustainable protein source, the industrial relevance of Tenebrio molitor, known as yellow mealworm, is set to increase substantially.
Isabelle Noyens +4 more
doaj +1 more source