Targeting interleukin-1β protects from aortic aneurysms induced by disrupted transforming growth factor β signaling [PDF]
, 2017 Aortic aneurysms are life-threatening conditions with effective treatments mainly limited to emergency surgery or trans-arterial endovascular stent grafts, thus calling for the identification of specific molecular targets.
Bizzotto, Dario +13 more
core +1 more source
A case of a highly tortuous descending thoracic aortic aneurysm treated by surgical exclusion
SAGE Open Medical Case Reports, 2020 The patient was a 76-year-old woman with an atypical descending thoracic aortic aneurysm due to a highly tortuous descending aorta. The surgical approach in this case required special consideration because of the aneurysm’s location. The main body of the
Koji Tsutsumi, Hideyuki Shimizu
doaj +1 more source
Heart failure and sudden cardiac death in heritable thoracic aortic disease caused by pathogenic variants in the SMAD3 gene [PDF]
, 2018 Background: Predominant cardiovascular manifestations in the spectrum of Heritable Thoracic Aortic Disease include by default aortic root aneurysms- and dissections, which may be associated with aortic valve disease.
Aalberts +23 more
core +2 more sources
Thoracic and Abdominal Aortic Aneurysms [PDF]
Circulation, 2005 Aneurysms of the aorta are at times evaluated and treated by physicians from a number of specialties. Indeed, whereas cardiac surgeons operate on the ascending aorta and arch and vascular surgeons manage abdominal aortic aneurysms, at present the responsibility often falls to cardiologists to oversee the medical care of patients with aortic disease of ...
openaire +2 more sources
Natural history of thoracic aortic aneurysms [PDF]
Journal of Vascular Surgery, 2012 Understanding the natural history of thoracic aortic aneurysms (TAAs) is essential to patient care and surgical decision making. In this evidence summary we discuss some of the most clinically relevant features of the disease. The true incidence of TAAs is likely to be higher than currently reported because of the inherently silent nature of TAAs ...
John A. Elefteriades +2 more
openaire +2 more sources
Aortic Pathology Determines Midterm Outcome After Endovascular Repair of the Thoracic Aorta Report From the Medtronic Thoracic Endovascular Registry (MOTHER) Database [PDF]
, 2013 Background—Endovascular repair of the thoracic aorta has become an increasingly utilized therapy. Although the short-term mortality advantage over open surgery is well documented, late mortality and the impact of presenting pathology on long-term ...
Benjamin Patterson +6 more
core +1 more source
Frontiers in Pharmacology, 2023 Introduction: Aortic aneurysm is a life-threatening disease resulted from progressive dilatation of the aorta, which can be subdivided into thoracic and abdominal aortic aneurysms.
Hong Wu +5 more
doaj +1 more source
Neural operator learning of heterogeneous mechanobiological insults contributing to aortic aneurysms [PDF]
arXiv, 2022 Thoracic aortic aneurysm (TAA) is a localized dilatation of the aorta resulting from compromised wall composition, structure, and function, which can lead to life-threatening dissection or rupture. Several genetic mutations and predisposing factors that contribute to TAA have been studied in mouse models to characterize specific changes in aortic ...
arxiv
Patient-specific predictions of aneurysm growth and remodeling in the ascending thoracic aorta using the homogenized constrained mixture model [PDF]
Biomechanics and Modeling in Mechanobiology, Springer Verlag,
2019, 18 (6), pp.1895-1913, 2019 In its permanent quest of mechanobiological homeostasis, our vascula-ture significantly adapts across multiple length and time scales in various physiological and pathological conditions. Computational modeling of vascular growth and remodeling (G\&R) has significantly improved our insights of the mechanobio-logical processes of diseases such as ...
arxiv +1 more source
Outcomes in the emergency endovascular repair of blunt thoracic aortic injuries [PDF]
, 2013 Thoracic aorta blunt injury (BAI) is a highly lethal lesion. A large number of victims die before obtaining emergency care. Thoracic endovascular aneurysm repair (TEVAR) is a less invasive method compared with open surgery and may change protocols for ...
Bertoletti G +5 more
core +1 more source