Results 121 to 130 of about 601,640 (261)

From structural repair to biomechanical compatibility: Aortic stiffness after open and endovascular aortic repair

Experimental Physiology, EarlyView.
Abstract Evaluation of aortic repair has traditionally prioritised perioperative safety, exclusion of the diseased segment and durability. As endovascular treatment expands to younger patients, attention is turning towards the biomechanical compatibility of prosthetic grafts with the native aorta.
Thurkga Moothathamby, Matti Jubouri, Fatima Kayali, Sakshi Roy, Subham Roy, Idhrees Mohammed, Ian M. Williams, Damian M. Bailey, Mohamad Bashir   +8 more
wiley   +1 more source

From maturation to degeneration: Distinct biological trajectories in bicuspid and tricuspid aortopathy

Experimental Physiology, EarlyView.
ABSTRACT Ascending thoracic aortic aneurysm formation differs fundamentally between patients with bicuspid (BAV) and tricuspid (TAV) aortic valve phenotypes, yet current clinical management largely relies on shared diameter thresholds, although clinical and scientific data fail to correlate with diameter and risk of rupture.
Riaz Akhtar, Daniel Olaf Riley, Jillian Madine, Mark Field   +3 more
wiley   +1 more source

Aortic remodeling predicts long-term survival and freedom from reintervention after thoracic endovascular aortic repair for chronic type B aortic dissection including residual type A dissection

JVS-Vascular Insights
Background: The optimal timing for thoracic endovascular aortic repair in chronic type B aortic dissection is controversial, largely because the long-term impact of aortic remodeling on clinical outcomes remains unclear.
Sadanari Sawaki, MD, PhD, Mika Kumagai, MA, Kazuki Nomura, MD, Shogo Maeda, MD, Riku Kato, MD, Tsubasa Yazawa, MD, Masayoshi Tokoro, MD, PhD, Ayumi Shintani, MPH, PhD, Toshiaki Ito, MD, PhD   +8 more
doaj   +1 more source

4D ultrasound reveals regional left atrial strain remodelling in a murine model of reversible pressure overload

The Journal of Physiology, EarlyView.
Abstract figure legend Traditional planar imaging approaches of the left atrium do not capture complex geometry. Four‐dimensional imaging allows the acquisition of 3D data + time to visualize left atrial geometry and kinematics. We designed an advanced analysis technique to investigate left atrial biomechanics in a model of pressure overload and ...
John P. Salvas, Thomas Moore‐Morris, Craig J. Goergen, Pierre Sicard   +3 more
wiley   +1 more source

Vascular smooth muscle cell mechanotransduction: Pathways, phenotypes and emerging technologies

The Journal of Physiology, EarlyView.
Abstract figure legend Vascular smooth muscle cells are exposed to mechanical stimuli from the blood flow and the extracellular matrix. The cells sense the signals from cyclic stretch, shear stress, hydrostatic pressure and matrix stiffness through specialized mechanosensors, such as mechanosensitive ion channels or cell surface receptors including ...
Nivethitha Kota Lakshminaraasimulu, Rachel E. A. Smyth, Aishwarya Prakash, Thomas Iskratsch   +3 more
wiley   +1 more source

Regional electrical differences and arrhythmia in the rat atria: Role of sympathetic nerve distribution and function

The Journal of Physiology, EarlyView.
Abstract figure legend Atrial fibrillation commonly develops in the left atrium and pulmonary veins (PVs), and can be triggered by sympathetic nerve activity. Here, we examined regional atrial differences in sympathetic nerve distribution and function in the rat.
James Saleeb‐Mousa, Manish Kalla, Neil Herring, Christopher O'Shea, Andrew M. Coney, Keith L. Brain, Andrew P. Holmes   +6 more
wiley   +1 more source

P2X3 receptor antagonism improves hindlimb blood flow during exercise in a conscious ovine model of hypertensive heart failure with preserved ejection fraction

The Journal of Physiology, EarlyView.
Abstract figure legend A preclinical large‐animal model of hypertensive heart failure with preserved ejection fraction (HFpEF) was used to examine the role of purinergic P2X3 receptor signalling during treadmill exercise. Animals were instrumented with either thoracic cardiac output and coronary flow probes or abdominal renal and hindlimb blood flow ...
Mridula Pachen, Siyi Chen, Joshua W.‐H. Chang, Audrys Pauza, Julia Shanks, Bindu George, Julian Paton, Rohit Ramchandra   +7 more
wiley   +1 more source

Exploring ethnic differences in the perioperative course of thoracic aortopathy

Frontiers in Cardiovascular Medicine
BackgroundIn patients with thoracic aortopathy post-operative recovery can be complicated by a lack of consistent, clear communication and guidance. Despite the growing recognition of these challenges, the specific needs of patients undergoing aortic ...
Nora Bacour, Aytug U. Tirpan, Simran Grewal, Robert J. M. Klautz, Robert J. M. Klautz, Nimrat Grewal, Nimrat Grewal, Nimrat Grewal   +7 more
doaj   +1 more source

Myocardial stretch‐induced ROS production is enhanced prior to the development of heart failure under TAC‐induced pressure overload

The Journal of Physiology, EarlyView.
Abstract figure legend To elucidate the relationship between oxidative stress in heart failure induced by chronic mechanical overload and physiological NOX2‐derived stretch‐induced reactive oxygen species (ROS) that support myocardial contractility during acute stretch, we investigated the changes in stretch‐induced ROS following transverse aortic ...
Yumiko Chiba, Keiko Kaihara, Hiroki Tanaka, Naoki Nakagawa, Gentaro Iribe   +4 more
wiley   +1 more source

Correlates of delayed recognition and treatment of acute type A aortic dissection: the International Registry of Acute Aortic Dissection (IRAD).

, 2011
Background— In acute aortic dissection, delays exist between presentation and diagnosis and, once diagnosed, definitive treatment. This study aimed to define the variables associated with these delays.
Isselbacher EM, Harris KM, Eagle KA, FATTORI, ROSSELLA, Nienaber CA, Evangelista A, Hirsch AT, Montgomery DG, Cooper JV, International Registry of Acute Aortic Dissection Investigators, Tsai TT, Strauss CE, Shiran H, Froehlich JB, Alan T. Hirsch, Thomas T. Tsai, James B. Froehlich, Hadas Shiran, Craig E. Strauss, Eric M. Isselbacher, Christoph A. Nienaber, Jeanna V. Cooper, Daniel G. Montgomery, Kim A. Eagle, Rossella Fattori, Arturo Evangelista, null null, Kevin M. Harris   +27 more
core   +1 more source