Results 141 to 150 of about 9,983,567 (363)

Inactivation of AXL in Cardiac Fibroblasts Alleviates Right Ventricular Remodeling in Pulmonary Hypertension

Advanced Science, EarlyView.
Pulmonary hypertension (PH) is a progressive condition with high morbidity and mortality, largely owing to right ventricular (RV) failure resulting from maladaptive remodeling. Our study provides strong evidence in support of a critical, detrimental role for AXL as a previously unrecognized determinant driving RV fibrotic pathology in PH.
Li‐Wei Wu, Min Chen, Chen‐Yu Jiang, Dai‐Ji Jiang, Xu Zhang, Xiao‐He Xu, Yi‐Wei Liu, Bei Feng, Lin‐Cai Ye, Yang‐Yang He, Xu Huang, Yi‐Chi Zhang, Xing‐Liang Zhou, Yi Shen, Tian‐Yu Liu, Li‐Jun Fu, Yi Yan, Hao Zhang   +17 more
wiley   +1 more source

PARPi Combining Nanoparticle LIN28B siRNA for the Management of Malignant Ascites

Advanced Science, EarlyView.
This study demonstrates that co‐inhibition of LIN28B and PARP using siLin28b/DSSP@lip‐PEG‐FA nanoparticles in combination with the PARP inhibitor BMN673 effectively suppresses the accumulation of malignant ascites associated with advanced cancers.
Yan Fang, Qian Shen, Yao Lin, Jing Zhu, Xiaolan Zhu, Rui Huang, Yijia Wu, Feiyang Shen, Qian Li, Guopei Zheng, Zhe Zhang, Qian Chu, Junhao Hu, Jianfeng Shen   +13 more
wiley   +1 more source

Value of peripheral blood circulating tumor cell detection in the diagnosis of thoracic diseases and the prediction of severity. [PDF]

Clin Exp Med, 2023
Qi C, Xiong XZ.
europepmc   +1 more source

Abstract No. 101 Outcomes of Chronic Thoracic Central Venous Recanalization Using Radiofrequency Guidewire Technology in Patients with End-Stage Renal Disease [PDF]

, 2023
Samuel B. Moawad, A. Vance, R. Cobb, M. Mantell, R. Cohean, T. Clark   +5 more
openalex   +1 more source

CD168 Identifies Proliferating Pancreatic Islet Cells in Murine and Human

Advanced Science, EarlyView.
This study identifies CD168 as a conserved surface marker for proliferating β‐cells in mouse, human islets, and pancreatic islet tumors. CD168⁺ cells show high proliferation and low insulin expression. CD168+ cells form mostly uni‐β lineage clones, and some of the clones are multi‐lineage.
Shubo Yuan, Jiafu Li, Min Shao, Haili Bao, Ajun Geng, Jialin Yang, Yu Tao, Xinyi Chen, Tianxiong Xiao, Chunye Liu, Zhiyao Xie, Wenqian Song, Qing Cissy Yu, Hongxing Fu, Xu Han, Taochen He, Wenquan Wang, Jianfeng Chen, Sheng Yan, Shaohua Song, Liang Liu, Yi Arial Zeng   +21 more
wiley   +1 more source

Primary Pulmonary Synovial Sarcoma: A Very Rare Presentation

Case Reports in Pulmonology, 2014
Synovial sarcoma (SS) is a rare tumor originating from mesenchymal tissue and accounting for approximately 5–10% of all soft tissue sarcomas.
Ekrem Cengiz Seyhan, Sinem Nedime Sokucu, Gulsah Gunluoglu, Nurdan Simsek Veske, Sedat Altin   +4 more
doaj   +1 more source

Characterizing Stage‐Specific Cellular Dynamics and Microenvironmental Remodeling in Lung Adenocarcinoma by Single‐Cell RNA Sequencing

Advanced Science, EarlyView.
This study integrated early‐stage patient specimens with publicly available datasets encompassing non‐malignant lung tissues and advanced‐stage LUAD through single‐cell sequencing, revealing a dynamically remodeled tumor microenvironment characterized by a hypoxia‐adapted malignant subset (C5), immunosuppressive LGMN+ macrophages, STAT1‐driven ...
Bomiao Qing, Xiaolan Li, Xiang He, Junyi Wang, Yi Yang, Manling Jiang, Bingbing Yan, Lei Zhang, Anying Xiong, Qin Ran, Guoping Li   +10 more
wiley   +1 more source

Preclinical and Toxicology Assessment of ALW-II-41-27, an Inhibitor of the Eph Receptor A2 (EphA2)

Drugs in R&D
Background and Objective The EphA2 receptor inhibitor ALW-II-41-27 has proven to be an effective in vitro antagonist of Pneumocystis β-glucan-induced proinflammatory signaling. This suggests its potential as a candidate for initial anti-inflammatory drug
Theodore J. Kottom, Kimberly E. Stelzig, Madeline R. Pellegrino, Marc Bindzus, Eunhee S. Yi, Andrew H. Limper   +5 more
doaj   +1 more source

Video-Assisted Thoracoscopic Sleeve Lobectomy Versus Open Approach in Non-Small Cell Lung Cancer: A Single-Center Study with Propensity Score Matching

Namık Kemal Tıp Dergisi
Aim: It was aimed to compare the outcomes of sleeve lobectomy with video-assisted thoracoscopic surgery (VATS) and thoracotomy in patients with centrally located non-small cell lung cancer (NSCLC).
Ece Yasemin DEMİRKOL, Volkan ERDOĞU, Melike ÜLKER, Merve EKİNCİ FİDAN, Nisa YILDIZ, Ezgi KILIÇASLAN, Celal Buğra SEZEN, Muzaffer METİN   +7 more
doaj   +1 more source

Prospective evaluation of thoracic diseases using a compact flat-panel detector spiral computed tomographic scanner. [PDF]

Eur J Radiol Open, 2022
Kim DS, Yoo SJ, Hong JH, Kwak N, Yim JJ, Yoon SH.   +5 more
europepmc   +1 more source