Results 31 to 40 of about 442,620 (354)

Sirtuin1 protects endothelial Caveolin-1 expression and preserves endothelial function via suppressing miR-204 and endoplasmic reticulum stress. [PDF]

, 2017
Sirtuin1 (Sirt1) is a class III histone deacetylase that regulates a variety of physiological processes, including endothelial function. Caveolin1 (Cav1) is also an important determinant of endothelial function. We asked if Sirt1 governs endothelial Cav1
Gabani, Mohanad, Irani, Kaikobad, Jacobs, Julia S, Kassan, Adam, Kassan, Modar, Kim, Young-Rae, Kumar, Santosh, Li, Qiuxia, Liu, Jing, Patel, Hemal H, Vikram, Ajit   +10 more
core   +3 more sources

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

The Diagnostic Efficiency of the Use of Non-Standard Surgical Instruments in Mediastinoscopy

İstanbul Medical Journal, 2022
Introduction:Mediastinoscopy is an effective diagnostic method used in the diagnosing of benign granulomatous diseases and for lung cancer staging. However, the success of this method is directly proportional to the amount of pathological material taken.
Kemal Karapınar, Merve Özbek, Yunus Seyrek, Cemal Aker, Ali Murat Akçıl, Levent Cansever, Mehmet Ali Bedirhan   +6 more
doaj   +1 more source

A Comprehensive Review on the Surgical Aspect of Lung Transplant Models in Mice and Rats

Cells, 2022
Lung transplantation improves the outcome and quality of life of patients with end-stage pulmonary disease. However, the procedure is still hampered by the lack of suitable donors, the complexity of the surgery, and the risk of developing chronic lung ...
Xin Jin, Janne Kaes, Jan Van Slambrouck, Ilhan Inci, Stephan Arni, Vincent Geudens, Tobias Heigl, Yanina Jansen, Marianne S. Carlon, Robin Vos, Dirk Van Raemdonck, Yi Zhang, Bart M. Vanaudenaerde, Laurens J. Ceulemans   +13 more
doaj   +1 more source

Novel application assigned to toluquinol: inhibition of lymphangiogenesis by interfering with VEGF-C/VEGFR-3 signalling pathway [PDF]

, 2016
BACKGROUND AND PURPOSE Lymphangiogenesis is an important biological process associated with the pathogenesis of several diseases, including metastatic dissemination, graft rejection, lymphoedema and other inflammatory disorders.
Blacher, S., García-Caballero, Melissa, Medina, Miguel Ángel, Nöel, Agnes, Pauper, J., Quesada, Ana R.   +5 more
core  

Idiopathic pulmonary fibrosis: prognostic impact of histologic honeycombing in transbronchial lung cryobiopsy

Multidisciplinary Respiratory Medicine, 2019
Background Prognostic evaluation in idiopathic pulmonary fibrosis (IPF) may be important as it can guide management decisions, but the potential role of honeycomb changes in providing information about outcome and survival of patients with IPF ...
Claudia Ravaglia, Marcello Bosi, Athol U. Wells, Carlo Gurioli, Christian Gurioli, Alessandra Dubini, Sara Piciucchi, Silvia Puglisi, Susanna Mascetti, Antonella Arcadu, Sara Tomassetti, Venerino Poletti   +11 more
doaj   +1 more source

Prognostic predictors for mortality of patients with COVID-19 in an intensive care unit

Journal of Infection in Developing Countries, 2022
Introduction: Fatality due to COVID-19 continues to be a challenge. Timely identification of critical COVID-19 patients is crucial for their close clinical follow-up and treatment.
Hulya Abali, Hatice Kutbay Ozcelik, Esra Akkutuk Ongel, Nazan Beyhan, Fatma Tokgoz Akyil, Seda Tural Onur, Sedat Altin   +6 more
doaj   +1 more source

ChestX-ray8: Hospital-scale Chest X-ray Database and Benchmarks on Weakly-Supervised Classification and Localization of Common Thorax Diseases

, 2017
The chest X-ray is one of the most commonly accessible radiological examinations for screening and diagnosis of many lung diseases. A tremendous number of X-ray imaging studies accompanied by radiological reports are accumulated and stored in many modern
Bagheri, Mohammadhadi, Lu, Le, Lu, Zhiyong, Peng, Yifan, Summers, Ronald M., Wang, Xiaosong   +5 more
core   +1 more source

Radiographic Outcomes of Adult Spinal Deformity Correction : A Critical Analysis of Variability and Failures Across Deformity Patterns [PDF]

, 2014
Study Design: Multicenter, prospective, consecutive, surgical case series from the International Spine Study Group. Objectives: To evaluate the effectiveness of surgical treatment in restoring spinopelvic (SP) alignment.
AMES, Christopher P., HART, Robert, KLINEBERG, Eric, LAFAGE, Virginie, MOAL, Bertrand, OHENEBA, Boachie-Adjei, PRAVEEN, Mummaneni, RYAN, Devon, SCHWAB, Franck, SHAFFREY, Christopher, SKALLI, Wafa, SMITH, Justin, TERRAN, Jamie   +12 more
core   +3 more sources

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source