Results 41 to 50 of about 296,123 (303)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

The Diagnostic Efficiency of the Use of Non-Standard Surgical Instruments in Mediastinoscopy

open access: yesİstanbul Medical Journal, 2022
Introduction:Mediastinoscopy is an effective diagnostic method used in the diagnosing of benign granulomatous diseases and for lung cancer staging. However, the success of this method is directly proportional to the amount of pathological material taken.
Kemal Karapınar   +6 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Robotic Surgery for Thoracic Disease

open access: yesAnnals of Thoracic and Cardiovascular Surgery, 2016
Robotic surgeries have developed in the general thoracic field over the past decade, and publications on robotic surgery outcomes have accumulated. However, controversy remains about the application of robotic surgery, with a lack of well-established evidence.
Yamashita, Shin-ichi   +2 more
openaire   +3 more sources

Idiopathic pulmonary fibrosis: prognostic impact of histologic honeycombing in transbronchial lung cryobiopsy

open access: yesMultidisciplinary Respiratory Medicine, 2019
Background Prognostic evaluation in idiopathic pulmonary fibrosis (IPF) may be important as it can guide management decisions, but the potential role of honeycomb changes in providing information about outcome and survival of patients with IPF ...
Claudia Ravaglia   +11 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Tratamiento endovascular de la aorta torácica mediante endoprótesis con escotadura distal [PDF]

open access: yes, 2011
[eng] “ENDOVASCULAR TREATMENT OF THORACIC AORTA WITH SCALLOPED THORACIC ENDOGRAFTS” Endovascular treatment of thoracic aortic disease (ETTAD) is often the only option for patients unfit for open surgery.
Maciel Da Rocha, Marcio Fernando
core  

A Review of Thoracic Aortic Aneurysm Disease [PDF]

open access: yesEcho Research & Practice, 2020
Abstract Aortic diseases may be diagnosed after a long period of subclinical development or they may have an acute presentation. Acute aortic syndrome is often the first sign of the disease, which needs rapid diagnosis and decision making to reduce the extremely poor prognosis. Aortic dilatation is a well-recognised risk factor for acute
Paul F Clift, Elena Cervi
openaire   +3 more sources

Prognostic predictors for mortality of patients with COVID-19 in an intensive care unit

open access: yesJournal of Infection in Developing Countries, 2022
Introduction: Fatality due to COVID-19 continues to be a challenge. Timely identification of critical COVID-19 patients is crucial for their close clinical follow-up and treatment.
Hulya Abali   +6 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

open access: yesFEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin   +12 more
wiley   +1 more source

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