Results 81 to 90 of about 288,852 (258)

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source

Could it Be Diagnosed Earlier? A Retrospective Analysis of Lung Cancer

Eurasian Journal of Medicine
Background: Early diagnosis is one of the most critical factors influencing the prognosis of lung cancer. This study aims to investigate radiological diagnostic delays and their underlying causes in lung cancer.
Fatma Tokgöz Akyıl, Hülya Abalı, Sinem Nedime Sökücü, Nurdan Şimşek Veske, Metin Sucu, Çiğdem Sabancı, Sida Gösterici, Sedat Altın   +7 more
doaj   +1 more source

Thoracic Diseases: Technique and Applications of Dual-Energy CT. [PDF]

Diagnostics (Basel), 2023
Perrella A, Bagnacci G, Di Meglio N, Di Martino V, Mazzei MA.   +4 more
europepmc   +1 more source

Mitigating Cancer Therapy–Related Cognitive Impairment by Targeted Activation of Undruggable Phosphatase

Advanced Science, EarlyView.
An RVG‑engineered exosomal saRNA delivery system (RVG‑EVs‑saPtpro) effectively targets and activates hippocampal PTPRO, functioning as a “molecular brake” to alleviate cancer therapy‑related cognitive impairment (CTRCI) by enhancing neuronal survival, neurogenesis, and synaptic plasticity.
Zhimeng Yao, Yuhua Meng, Huanyi Li, Yinhui Jiang, Xiaona Lin, Mengyuan Hu, Qing Liu, Xiaofu Qiu, Hongzheng Ren, Yunlong Pan, Bin Pan, Zexiong Guo, Shuyao Zhang, Dianzheng Zhang, Li Yang, Shegan Gao, Weijing Deng, Jianfan Chen, Hao Zhang   +18 more
wiley   +1 more source

Applications of Robotic Surgery in Thoracic Diseases. [PDF]

J Clin Med, 2022
Casiraghi M, Mariolo AV, Spaggiari L.
europepmc   +1 more source

Engineering Immunoregenerative Therapy via an Immunomodulatory Binary Pharmacology Hydrogel Depot for Prolonged Allograft Survival

Advanced Science, EarlyView.
An immunomodulatory hydrogel (iGEL) forms spontaneously upon subcutaneous injection, acting as a tissue‐adhesive depot. It releases anti‐rejection and regenerative agents in response to inflammation, suppressing T‐cell activity, promoting vascular repair, and restoring allograft function without systemic immunosuppression.
Ning Wang, Ruiqi Sun, Yang Fu, Zhonghan Wu, Xinyu Tong, Hong Tang, Wentao Zhao, Zhi Liang, Jintao Zheng, Yanan Guan, Ke Zhou, Penghong Song, Shusen Zheng, Hangxiang Wang, Haiyang Xie   +14 more
wiley   +1 more source

Approach to the athlete with thoracic aortic disease

Current Sports Medicine Reports, 2007
Sports medicine specialists have a unique opportunity to identify individuals who may be at risk for thoracic aortic disease. These patients may have physical features such as tall stature and long limbs (which typify Marfan syndrome), but also lend themselves to participation in competitive athletics.
Ibrahim M, Saeed, Alan C, Braverman
openaire   +3 more sources

FUCA2 Sustains AKT Signaling and Suppresses Senescence by Antagonizing FUT3‐Mediated ErbB3 Fucosylation in Lung Adenocarcinoma

Advanced Science, EarlyView.
ABSTRACT While targeted therapies have improved outcomes in lung adenocarcinoma (LUAD), many patients still lack targetable mutations. Here, we identified alpha‐L‐fucosidase 2 (FUCA2) as a crucial driver of LUAD by preventing cellular senescence. Mechanistically, through the restriction of fucosyltransferase 3 (FUT3)‐mediated α‐1,3‐fucosylation of ...
Lu Chen, Jintao Guo, Fei Li, Mingjie Gao, Runyang Li, Zhaozhang Huang, Yaolin Zheng, Chunyi Gao, Jihuan Hou, Qiang Yu, Bowen Zheng, Xuemei Chen, Wenqing Zhang, Xiaoting Hong, Yali Zheng, Daxuan Wang, Qiyuan Li, Tianhui Hu, Yan‐yan Zhan   +18 more
wiley   +1 more source

Controlled Hypothermic Storage for Lung Preservation: Leaving the Ice Age Behind

Transplant International
Controlled hypothermic storage (CHS) is a recent advance in lung transplantation (LTx) allowing preservation at temperatures higher than those achieved with traditional ice storage.
Ismail Cenik, Ismail Cenik, Jan Van Slambrouck, Jan Van Slambrouck, An-Lies Provoost, An-Lies Provoost, Annalisa Barbarossa, Annalisa Barbarossa, Cedric Vanluyten, Cedric Vanluyten, Caroline Boelhouwer, Caroline Boelhouwer, Bart M. Vanaudenaerde, Robin Vos, Robin Vos, Jacques Pirenne, Jacques Pirenne, Dirk E. Van Raemdonck, Dirk E. Van Raemdonck, Laurens J. Ceulemans, Laurens J. Ceulemans   +20 more
doaj   +1 more source

Value of peripheral blood circulating tumor cell detection in the diagnosis of thoracic diseases and the prediction of severity. [PDF]

Clin Exp Med, 2023
Qi C, Xiong XZ.
europepmc   +1 more source