Results 71 to 80 of about 630,098 (253)

SerpinA3 is an Endogenous TGF‐β Receptor Antagonist that Attenuates Cardiac Fibroblast Activation and Fibrotic Remodeling

Advanced Science, EarlyView.
SerpinA3 acts as an endogenous TGF‐β receptor antagonist that binds to the extracellular domain of TGFR‐1, thereby preventing TGFR‐1–TGFR‐2 complex formation. This receptor‐level blockade suppresses TGF‐β/Smad2/3 signaling, attenuates cardiac fibroblast activation, and extracellular matrix deposition, and ultimately alleviates pressure overload–induced
Hui Wang, Jieyu Cui, Chunlu Huang, Wanyi Guo, Tong Liu, Yi Zhu, Shuai Shao, Kangyin Chen, Jinlong He, Qiankun Bao   +9 more
wiley   +1 more source

War in Croatia and thoracic war injuries - retrospective study of 454 cases in period 1992-1995

, 2006
Aim: To present our experience in treatment of thoracic war injuries and to suggest an optimal surgical approach. Methods: Total of 454 patients with thoracic war injuries are included in the study. Data are collected during Aug. 1992 − Dec.
Petricevic, Ante, Bunclic, Josip, Ilic, Nenad   +2 more
core   +1 more source

Ferimentos penetrantes tóraco-abdominais e de tórax e abdome: análise comparativa da morbidade e mortalidade pós-operatórias

Revista do Colégio Brasileiro de Cirurgiões
Analisamos 145 doentes portadores de ferimentos penetrantes tóraco-abdominais e de tórax e abdome, operados no Serviço de Emergência da Santa Casa de São Paulo de julho de 1987 a fevereiro de 1996, sendo 72 (49,7%) produzidos por arma branca e 73 (50,3%)
Jacqueline Arantes Giannini, Samir Rasslan, Leonardo Emílio da Silva, Raul Coimbra, Roberto Saad Júnior   +4 more
doaj   +1 more source

An RNA‐Binding Protein RBMS1 Promotes Endothelial Cell Autophagy to Maintain Vascular Homeostasis and Suppress Deep Vein Thrombosis

Advanced Science, EarlyView.
RBMS1, an RNA‐binding protein, restores vascular endothelial homeostasis by enhancing ATG3‐mediated autophagy, thereby attenuating thrombus formation and suggesting a potential avenue for further therapeutic exploration in DVT. ABSTRACT Deep vein thrombosis (DVT) is a prevalent vascular disorder characterized by aberrant coagulation within the deep ...
Chu Chu, Xinkui Liu, Nannan Fan, Xiaoyan Yu, Qiaoqiao Han, Yunhong Zhang, Wei Li, Yongqing Cai, Miaomiao Zhou, Fang Li, Feifei Shi, Zhen Zhang, Bin Wang, Xia Li   +13 more
wiley   +1 more source

ACSL4‐Dependent Lysosomal Lipid Peroxidation Links WTAP‐Mediated m6A Modification to Intervertebral Disc Degeneration

Advanced Science, EarlyView.
IL‐1β upregulates the protein level of WTAP, which promotes the m6A modification of ACSL4 mRNA in an IGF2BP2‐dependent manner, thereby enhancing its stability. The increased ACSL4 drives lipid peroxidation, leading to lysosomal membrane permeabilization (LMP) and impaired mitophagy, which collectively accelerate intervertebral disc degeneration (IVDD).
Shu Jia, Xu Gao, Laimin Zhu, Haixia Song, Jing Wu, Shang Chen, Sheng Gao, Lu Zhang, Chunyang Meng   +8 more
wiley   +1 more source

Rare case of impalement of two occupants of a vehicle

Chinese Journal of Traumatology, 2012
【Abstract】 Thoracic impalement injuries are very rare and the majority of patients do not survive to reach a medical care facility. In this case report, we describe the successful outcome of a case of double thoracic impale-ment by two steel tors, of ...
Singhal Maneesh, Kumar Madduri Vijay, Prakash Prem, Gupta Amit, Kumar Subodh, Sagar Sushma   +5 more
doaj  

Clavicle fractures and high‐grade acromioclavicular joint injuries do not affect posture and thoracic kyphosis in young adults: A prospective comparative study

Journal of Experimental Orthopaedics
Purpose Clavicle fractures and high‐grade acromioclavicular joint injuries are frequently associated with altered shoulder‐girdle function, but their impact on spinal posture remains unclear.
Jan‐Marek Meyer, Richard Julius Freytag, Ismaiel Al‐Ramadani, Mohammad Masoud, Jonathan Sommer, Jakob Zapatka, Alessandra Menon, Davide Cucchi   +7 more
doaj   +1 more source

Thoracic Injury Rule out Criteria in Prediction of Traumatic Intra-thoracic Injuries; a Validation Study

Archives of Academic Emergency Medicine, 2017
Introduction: Doing Chest X Ray (CXR) for all trauma patients is not efficient and cost effective due to its low diagnostic value. The present study was designed aiming to evaluate the diagnostic accuracy of thoracic injury rule out criteria (TIRC) in ...
Setareh Asgarzadeh, Bahareh Feizi, Farhad Sarabandi, Morteza Asgarzadeh   +3 more
doaj   +1 more source

THSD7A Exacerbates Atherosclerosis via Activation of Signaling Axis αvβ3/CEBPD/IL1A

Advanced Science, EarlyView.
THSD7A exerts pro‐inflammatory effects and exacerbates atherosclerosis. Mechanistically, THSD7A regulates endothelial cell inflammation and atherosclerosis by activating the αvβ3/CEBPD/IL1A signaling axis. THSD7A is not only a genetic marker but also a potential therapeutic target for coronary artery disease (CAD).
Jiankun Liu, Hongfei Liu, Yiqi Wan, Andong Wu, Jiayu Qiu, Xueting Gong, Ya Zhao, Yuanyuan Li, Bingbing Zhou, Yangyi Zheng, Fang Wu, Yuanzheng Zhu, Weixin Lv, Xueer Li, Qiang Yuan, Xiao‐Li Tian   +15 more
wiley   +1 more source

A Huaxian Formula Nanoformulation Confers Protection Against Acute Radiation‐Induced Lung Injury by Targeting Ferroptosis

Advanced Science, EarlyView.
An inhalable, nanoengineered herbal therapy achieves protection against acute radiation‐induced lung injury via self‐assembled nanomicelle‐mediated pulmonary targeting and a previously unrecognized dual mechanism that attenuates oxidative stress while inhibiting ferroptosis in alveolar epithelial cells.
Li Quan, Junyang Chen, Xingmin Chen, Zengyi Fang, Yuanzhen Mi, Pingjin Zou, Shunlian Fu, Huakang Li, Ke Xu, Bing Lin, Jinyi Lang, Meihua Chen   +11 more
wiley   +1 more source